Institute of Neuroscience

Staff Profile

Professor David Brooks

Prof of Clinical PET Research

Background

David J Brooks MD DSc FRCP(UK) FMed Sci (UK) is Professor of PET Clinical Science at Newcastle University,  Visiting Professor of Neurology in the Department of Medicine, Imperial College London and part-time Professor of Neurology at Dept of Nuclear Medicine, Aarhus University, Denmark. He is on the Grant Awards Board of Alzheimer Research UK, the Biomedical Research Advisory Panel of Alzheimer UK, and was on the Scientific Advisory Boards of Parkinson’s UK, and the German Dementia and Parkinson Kompetenz Networks. He is the Chairman of the NUHS Scientific Advisory Panel, Singapore and was a member of the Scientific Advisory Board of the Michael J. Fox Foundation for Parkinson's Disease Research (2002-2006), UK Medical Research Council Neuroscience and Mental Health Board (2004-2007), Wellcome Trust Neuroscience Panel (2001-2003) and was Chairman of the Scientific Issues Committee of the Movement Disorder Society (1998-2002).

He is an Associate Editor of Brain and is on the Editorial Boards of Annals of Neurology, Journal of Parkinson’s Disease, Synapse, and Basal Ganglia. He was on the Editorial Boards of Movement Disorders 1994-1998 and Parkinsonism and Related Disorders 2012-2016. In 2001 he was elected a Fellow of the Academy of Medical Science, UK. His research involves the use of positron emission tomography and magnetic resonance imaging to diagnose and study the progression of Alzheimer’s and Parkinson’s disease and his work is on the highly cited list with an h index of 106. He has been a recipient of  a Danish Alzheimer Foundation Prize, the Kuhl-Lassen award  (Society of Nuclear Medicine), and was invited to give the Stahn Fahn (International Movement Disorder Society) and Cotzias (Spanish Neurology Society) Lectures. He is a consultant for GE Healthcare, Biogen, Plexxikon, and GenePod.

Selected Publications  (h index 106)

1.      Brooks DJ,  et al. Differing patterns of striatal 18F-dopa uptake in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Ann Neurol. 1990; 28: 547-555.

2.      Koepp MJ, … Brooks DJ, … Grasby PM. Evidence for striatal dopamine release during a video game. Nature 1998; 393: 266-268.

3.      Cagnin A, Brooks DJ, et al. In vivo measurement of microglial  activation  in dementia. Lancet  2001;  358: 461-467.

4.      Gill SS, … Brooks DJ, … Heywood  P. Direct brain infusion of glial cell line-derived neu rotrophic  factor  (GDNF)  in  Parkinson's  Disease.  Nature Medicine 2003; 9: 589-595.

5.      Rinne JO, Brooks DJ, et al. [11C]PiB PET supports reduced cortical fibrillar Ag  in Alzheimer's disease patients  treated  with  bapineuzumab. Lancet Neurol 2010;  9:  363-372.

6.      Piccini P, Brooks DJ, Bjorkl und A, Gunn RN, Grasby PM, Rimoldi 0, Brundi n P, Hagell P, Rehncrona S, Widner H, Lindvall O. Dopamine release from nigral tra nsplants visualised in vivo in a Parkinson's patient. Nature Neuroscience 1999;  2:  1137-1140. 

7.    Rascol O, Brooks DJ, Korczyn AD, De Deyn P, Clarke C, Lang AE. Dyskinesia in Parkinson's Disease: A 5-Year Study of ropinirole versus levodopa. New Eng.J Med. 2000; 342: 1484-1491.

Publications