Dr Gerrit Hilgen
- Email: email@example.com
- Telephone: +44(0)191 208 8933
- Address: Institute of Neuroscience
Faculty of Medical Sciences
Newcastle upon Tyne
MG 178 Cookson Building
My general scientific interest is on sensory signal processing and neuronal networks. During my PhD, I worked on the retina and shed light on specialised cell-cell connections which form dynamic networks between neurons and allow rapid propagation and integration of signals. After my PhD, I expanded my knowledge to the tactile sensory system. I assembled a voltage sensitive dye imaging system and developed my own computational imaging processing approaches to study how the networks in the leech accomplish the integration of tactile sensory input. In 2013, my interest switched back to the retina and I started working with large-scale high density multi-electrode array recordings in combination with structural imaging. This novel strategy is well suited for my own scientific interests because it allows to reveal how all the different cells in the retina work simultaneously together and shape the neural image that is sent to the brain.
April 2017- Postdoctoral Research Associate in the lab of Dr. E. Sernagor, Newcastle University, UK
Sept. 2013- Mar. 2017 Postdoctoral Research Associate in the lab of Dr. E. Sernagor, Newcastle University, UK
Mar. 2012- Aug. 2013 Postdoctoral Researcher in the lab of Prof. J. Kretzberg, University of Oldenburg, Germany
2007-2012 PhD in Neurobiology, University of Oldenburg, Germany.
Thesis title: Expression and functional role of the solute carrier NCBE and the gap junction proteins connexin45 and connexin57 in the mouse retina. Supervisor: apl. Prof. Dr. Karin Dedek
2001-2007 Diploma in Cell Biology, Biochemistry and Physiology, University of Oldenburg, Germany.
Thesis title: Cx57 modulation and localization in the mouse retina. Supervisors: apl. Prof. Ulrike Janssen-Bienhold and Prof. Reto Weiler
Society for Neuroscience
TeachingI supervise(d) undergraduate, masters and PhD students in Newcastle and Oldenburg.
- Hilgen G, Pirmoradian S, Pamplona D, Kornprobst P, Cessac B, Hennig MH, Sernagor E. Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina. Scientific Reports 2017, 7, 42330.
- Hilgen G, Sorbaro M, Pirmoradian S, Muthmann JO, Kepiro IE, Ullo S, Ramirez CJ, Puente Encinas A, Maccione A, Berdondini L, Murino V, Sona D, Cella Zanacchi F, Sernagor E, Hennig MH. Unsupervised Spike Sorting for Large-Scale, High-Density Multielectrode Arrays. Cell Reports 2017, 18(10), 2521–2532.
- Barrett JM, Hilgen G, Sernagor E. Dampening Spontaneous Activity Improves the Light Sensitivity and Spatial Acuity of Optogenetic Retinal Prosthetic Responses. Scientific Reports 2016, 6, 33565.
- Kretzberg J, Pirschel F, Fathiazar E, Hilgen G. Encoding of Tactile Stimuli by Mechanoreceptors and Interneurons of the Medicinal Leech. Frontiers in Physiology 2016, 7, 1-15.
- Portelli G, Barrett JM, Hilgen G, Masquelier T, Maccione A, DiMarco S, Berdondini L, Kornprobst P, Sernagor E. Rank Order Coding: a Retinal Information Decoding Strategy Revealed by Large-Scale Multielectrode Array Retinal Recordings. eNeuro 2016, 3(3), 1-18.
- Pamplona D, Hilgen G, Pirmoradian S, Hennig MH, Cessac B, Sernagor E, Kornprobst P. A super-resolution approach for receptive fields estimation of neuronal ensembles. BMC Neuroscience 2015, 16(Suppl. 1), 1-2.
- Meyer A, Hilgen G, Dorgau B, Sammler EM, Weiler R, Monyer H, Dedek K, Hormuzdi SG. AII amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions. Journal of Cell Science 2014, 127, 1190-1202.
- Fathiazar F, Hilgen G, Kretzberg J. Removing bleaching artifacts from voltage sensitive dye recordings with ICA. BMC Neuroscience 2013, 14(Suppl. 1), P222.
- Hilgen G, Huebner AK, Tanimoto N, Sothilingam V, Seide C, Garrido MG, Schmidt KF, Seeliger MW, Löwel S, Weiler R, Hübner CA, Dedek K. Lack of the sodium-driven chloride bicarbonate exchanger NCBE impairs visual function in the mouse retina. PLoS ONE 2012, 7(10), e46155.
- Hilgen G, Maltzahn J, Willecke K, Weiler R, Dedek K. Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina. Journal of Comparative Neurology 2011, 519(3), 433-450.
- Janssen-Bienhold U, Trümpler J, Hilgen G, Schultz K, Müller LP, Sonntag S, Dedek K, Dirks P, Willecke K, Weiler R. Connexin57 is expressed in dendro-dendritic and axo-axonal gap junctions of mouse horizontal cells and its distribution is modulated by light. J Comp Neurol 2009, 513(4), 363-74.