People - Institute of Neuroscience - Newcastle University

Professor Heinz Grunze
Prof of Clinical Psychiatry

Email: heinz.grunze@ncl.ac.uk
Telephone: +44 (0) 191 256 3219
Fax: +44 (0) 191 256 3324
Address: Academic Psychiatry
1st Floor, Building 15
Newcastle General Hospital
Westgate Road
Newcastle upon Tyne
NE4 6BE, UK

Publications

Grunze H, Fyans P. Comparative efficacy of anti-manic drugs in acute mania. Lancet 2012, 379(9819), 893-893.
Gerber SI, Krienke UJ, Biedermann NC, Grunze H, Yolken RH, Dittmann S, Langosch JM. Impaired functioning in euthymic patients with bipolar disorder - HSV-1 as a predictor. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2012, 36(1), 110-116.
Watkins HB, Nendick J, Atkinson L, Ferrier IN, Grunze H, Scott J, Meyer TD. Investigating impulsivity in bipolar II disorder: more state than trait?. In: 5th Biennial Conference of the International Society for Bipolar Disorders. 2012, Istanbul, Turkey: Wiley-Blackwell Publishing, Inc.
Correll C, Vieta E, Gitlin M, Grunze H. Making the right decisions to prevent recurrence in the long-term treatment of bipolar disorder. In: Bipolar Disorders: 5th Biennial Conference of the International Society for Bipolar Disorders. 2012, Istanbul, Turkey: Wiley-Blackwell Publishing Ltd.
Nendick J, Watkins H, Atkinson L, Ferrier IN, Grunze H, Meyer T, Scott J. Met and unmet needs: evidence of significant health and social problems in bipolar II disorders from the MRC UK, 'ABC' Cohort study. In: 5th Biennial Conference of the International Society for Bipolar Disorders. 2012, Istanbul, Turkey: Wiley-Blackwell Publishing Ltd.
Goodwin GM, Abbar M, Schlaepfer TE, Grunze H, Licht RW, Bellivier F, Fountoulakis KN, Altamura AC, Pitchot W, Agren H, Holsboer-Trachsler E, Vieta E. Aripiprazole in patients with bipolar mania and beyond: an update of practical guidance. Current Medical Research and Opinion 2011, 27(12), 2285-2299.
Grunze H. At the edge of the bipolar spectrum: primacy of affective over psychotic symptoms or vice versa?. World Psychiatry 2011, 10(3), 197-198.
Vieta E, Grunze H. Bipolar Disorder - A Focus on Depression. New England Journal of Medicine 2011, 364(16), 1581-1581.
Post RM, Leverich GS, Altshuler LL, Frye MA, Suppes T, Keck PE, McElroy SL, Nolen WA, Kupka R, Grunze H, Walden J, Rowe M. Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany. International Clinical Psychopharmacology 2011, 26(2), 96-106.
Post R, Altshuler L, Leverich G, Frye M, Suppes T, McElroy S, Keck P, Nolen W, Grunze H, Rowe M, Kupka R. More Stressors and Bipolar Illness Adversity in US than Europe [abstract]. In: Biological Psychiatry: 66th Annual Meeting of the Society of Biological Psychiatry. 2011, San Francisco, California, USA: Elsevier Inc.
Sharma A, Barron J, Le Couteur J, Grunze H, Kelly T, Ferrier I, Close A, Rushton S, Le Couteur A. Neurocognitive function in children of adults with bipolar disorder: a UK study. In: Bipolar Disorders: 9th International Conference on Bipolar Disorder. 2011, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell Publishing, Inc.
Sharma A, Neely J, Camilleri N, Grunze H, James A, Ferrier IN, LeCouteur AS. Surveillance of Paediatric bipolar I disorder in the United Kingdom (UK) and the Republic of Ireland (ROI) - results from year 1. In: Bipolar Disorders: 9th International Conference on Bipolar Disorder. 2011, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell Publishing, Inc.
Grunze H. The Clinical Side of Bipolar Disorders. Pharmacopsychiatry 2011, 44(1), S43.
Schaerer LO, Dittmann S, Grunze H, Post RM, Bipolar Cooperative Network. Women react different to valproic acid at different age ranges then men. In: Bipolar Disorders: 9th International Conference on Bipolar Disorder. 2011, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell Publishing, Inc.
Grunze H, Dargel S. Acute and long-term treatment for bipolar depression. Nervenarzt 2010, 81(5), 539-548.
Post R, Altshuler L, Frye M, Suppes T, Keck P, McElroy S, Leverich G, Luckenbaugh D, Rowe M, Pizzarello S, Kupka R, Grunze H, Nolen W. Complexity of pharmacologic treatment required for sustained improvement in outpatients with bipolar disorder. Journal of Clinical Psychiatry 2010, 71(9), 1176-1186.
Post R, Leverich G, Kupka R, Keck P, McElroy S, Altshuler L, Frye M, Luckenbaugh D, Rowe M, Grunze H, Suppes T, Nolen W. Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood. Journal of Clinical Psychiatry 2010, 71(7), 864-872.
Altshuler LL, Kupka RW, Hellemann G, Frye MA, Sugar CA, McElroy SL, Nolen WA, Grunze H, Leverich GS, Keck PE, Zermeno M. Gender and Depressive Symptoms in 711 Patients With Bipolar Disorder Evaluated Prospectively in the Stanley Foundation Bipolar Treatment Outcome Network. American Journal of Psychiatry 2010, 167(6), 708-715.
Post RM, Nolen WA, Kupka RW, Altshuler LL, Frye MA, Suppes T, McElroy SL, Keck PE, Grunze H, Rowe M, Leverich GS. Increased risk factors and poor long-term outcome in the US compared to Holland and Germany. In: Bipolar Disorders: 4th Biennial Conference of the International Society for Bipolar Disorders. 2010, Sao Paulo, Brazil: Wiley-Blackwell.
Suppes T, Hellemann G, Frye MA, McElroy S, Nolen W, Kupka R, Leverich G, Grunze H. Mixed depression in bipolar disorder: prevalence rate and clinical correlates during naturalistic follow up. In: Bipolar Disorders: 4th Biennial Conference of the International Society for Bipolar Disorders. 2010, Sao Paulo, Brazil: Wiley-Blackwell.
Dittmann S, Seemuller F, Hennig-Fast K, Engel RR, Riedel M, Grunze H, Severus WE. Predictors of functioning in bipolar disorder. In: European Neuropsychopharmacology: 23rd Congress Meeting of European College of Neuropsychopharmacology. 2010, Amsterdam, Netherlands: Elsevier BV.
Robertson B, Grunze H, Versavel M, Costa R, Almeida L, Soares da Silva P. Results of a double-blind, randomized, dose-titration, placebo controlled multicenter trial (SCO/BIA-2093-203 study) on safety and efficacy of eslicarbazepine acetate (BIA 2-093) for acute manic episodes associated with biopolar I disorder. In: Bipolar Disorders: 4th Biennial Conference of the International Society for Bipolar Disorders. 2010, Sao Paulo, Brazil: Wiley-Blackwell.
Benninghoff J, Gritti A, Rizzi M, LaMorte G, Schloesser RJ, Schmitt A, Robel S, Genius J, Moessner R, Riederer P, Manji HK, Grunze H, Rujescu D, Moeller HJ, Lesch KP, Vescovi AL. Serotonin Depletion Hampers Survival and Proliferation in Neurospheres Derived from Adult Neural Stem Cells. Neuropsychopharmacology 2010, 35(4), 893-903.
Born C, Dittmann S, Biedermann C, Seemuller F, Amann B, Grunze H, Scharer L. Validity of the "National Institute of Mental Health Life Chart - Self Version" (NIHM-SLCM). In: Bipolar Disorders: 4th Biennial Conference of the International Society for Bipolar Disorders. 2010, Sao Paulo, Brazil: Wiley-Blackwell.
Born C, Dittmann S, Biedermann C, Seemuller F, Amann B, Grunze H, Scharer L. Validity of the "National Institute of Mental Health Life Chart - Self Version" (NIHM-SLCM). In: Bipolar Disorders: 4th Biennial Conference of the International Society for Bipolar Disorders. 2010, Sao Paulo, Brazil: Wiley-Blackwell Publishing, Inc.
Schaerer LO, Langosch J, Dittmann S, Grunze H, Post RM. A strong bimodal effect of age on severity shows that linear models are not sufficient to control the effects of age in bipolar disorder. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, PA: Wiley-Blackwell.
Dittmann S, Grunze H, Kupka R, Nolen W, Bauer M, Scharer L, Walden J, Post R, Frye M. Acamprosate in bipolar disorder: an open-label pilot study. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell.
Dittmann S, Grunze HC, Kupka R, Nolen W, Bauer M, Scharer L, Walden J, Post R, Frye M. Acamprosate in bipolar disorder: an open-label pilot study. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell Publishing, Inc.
Seemuller F, Dittmann S, Grunze H, Obermeier M, Riedel M, Severus E. Are atypical depression and bipolar depression the same?. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell.
Kupka RW, Post RM, Altshuler LL, Frye MA, Grunze H, Keck PE, Leverich GS, McElroy SL, Suppes T, Nolen WA. Borderline personality features in rapid cycling bipolar disorder in relationship to episode frequency. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell.
Frye MA, Hellemann G, McElroy SL, Altshuler LL, Black DO, Keck PE, Nolen WA, Kupka R, Leverich GS, Grunze H, Mintz J, Post RM, Suppes T. Correlates of Treatment-Emergent Mania Associated With Antidepressant Treatment in Bipolar Depression. American Journal of Psychiatry 2009, 166(2), 164-172.
Post RM, Leverich GS, Kupka R, Keck P, McElroy S, Altshuler L, Frye M, Luckenbaugh DA, Rowe M, Grunze H, Suppes T, Nolen WA. Delay to first treatment is inversely related to age of onset of bipolar disorder and an independent contributor to a poor outcome in adulthood. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell.
Grunze H. How to manage mania not responding to a first-step 2 weeks treatment with quetiapine - a report from a prematurely discontinued randomised clinical trial Invited Comment. Acta Psychiatrica Scandinavica 2009, 120(4), 335-335.
Altshuler LL, Post RM, Hellemann G, Leverich GS, Nolen WA, Frye MA, Keck PE, Kupka RW, Grunze H, McElroy SL, Sugar CA, Suppes T. Impact of Antidepressant Continuation After Acute Positive or Partial Treatment Response for Bipolar Depression: A Blinded, Randomized Study. Journal of Clinical Psychiatry 2009, 70(4), 450-457.
Severus WE, Seemuller F, Grunze H, Obermeier M, Bernhard B, Dittmann A, Moller HJ, Riedel M. Intravenous omega-3 fatty acids in the acute treatment of inpatients with bipolar depression. A pilot study. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell.
Severus WE, Seemuller F, Grunze H, Obermeier M, Bernhard B, Dittmann A, Moller HJ, Riedel M. Intravenous omega-3 fatty acids in the acute treatment of inpatients with bipolar depression. A pilot study. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell Publishing, Inc.
Grunze H. Long-term management of bipolar disorder. In: European Neuropsychopharmacology: 22nd Congress of the European College of Neuropsychopharmacology. 2009, Istanbul, Turkey: Elsevier BV.
Dittmann S, Seemuller F, Severus WE, Hennig-Fast K, Engel RR, Riedel M, Grunze HC. Memory predicts social adjustment in bipolar disorder. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell.
Dittmann S, Seemuller F, Severus WE, Hennig-Fast K, Engel RR, Riedel M, Grunze HC. Memory predicts social adjustment in bipolar disorder. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell Publishing, Inc.
Frye M, Hellemann G, Suppes T, McElroy S, Grunze H, Altshuler L, Keck P, Kupka R, Nolen W, Leverich G, Post R. Prevalence rate of mixed depression and its impact on remission: a controlled evaluation. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell.
Frye M, Hellemann G, Suppes T, McElroy S, Grunze H, Altshuler L, Keck P, Kupka R, Nolen W, Leverich G, Post R. Prevalence rate of mixed depression and its impact on remission: a controlled evaluation. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell Publishing, Inc.
Grunze H, Vieta E, Goodwin G, Bowden C, Licht R, Moeller HJ, Kasper S. The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines. In: European Neuropsychopharmacology: 22nd Congress of the European College of Neuropsychopharmacology. 2009, Istanbul, Turkey: Elsevier BV.
Schaerer LO, Meltzer K, Graf M, Cervantes P, Langosch J, Grunze H. Validation of the Personal LifeChart System for English and German language. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell.
Schaerer LO, Meltzer K, Graf M, Cervantes P, Langosch J, Grunze H. Validation of the Personal LifeChart System for English and German language. In: Bipolar Disorders: 8th International Conference on Bipolar Disorder. 2009, Pittsburgh, Pennsylvania, USA: Wiley-Blackwell Publishing, Inc.
Born C, Dittmann S, Biedermann C, Seemuller F, Amann B, Grunze H, Scharer LO. Validity of the National Institutes of Mental Health Life Chart self version (NIHM-sLCM). In: Pharmacopsychiatry: 26th Symposium of the Association of Neuropsychopharmacology and Pharmacopsychiatry (AGNP). 2009, Munich, Germany: Georg Thieme Verlag.
Born C, Dittmann S, Biedermann C, Seemuller F, Amann B, Grunze H, Scharer LO. Validity of the National Institutes of Mental Health Life Chart self version (NIHM-sLCM). In: Pharmacopsychiatry: 26th Symposium of the Association of Neuropsychopharmacology and Pharmacopsychiatry (AGNP). 2009, Munich, Germany: Georg Thieme Verlag.
Bowden C, Gogus A, Grunze H, Haggstrom L, Rybakowski J, Vieta E. A 12-week, open, randomized trial comparing sodium valproate to lithium in patients with bipolar I disorder suffering from a manic episode. International Clinical Psychopharmacology 2008, 23(5), 254-262.
Baghai TC, Grunze H, Sartorius N. An overview of the methodology used to produce CINP Task Force report on antidepressant medications. In: The International Journal of Neuropsychopharmacology: 26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP). 2008, Munich, Germany: Cambridge University Press.
Baghai TC, Grunze H, Sartorius N. An overview of the methodology used to produce CINP Task Force report on antidepressant medications. International Journal of Neuropsychopharmacology 2008, 11(S1), 26.
Forsthoff AC, Grunze HC, Seemueller F, Zetzsche T, Moeller HJ, Meisenzahl EM. Differences of gray matter volume and relation to clinical outcome in bipolar patients versus healthy controls - An MRI study. In: Bipolar Disorders: 3rd Biennial Conference of the International Society for Bipolar Disorders. 2008, New Delhi, India: Blackwell Publishing Ltd.
Langosch JM, Drieling T, Biedermann NC, Born C, Sasse J, Bauer H, Walden J, Bauer M, Grunze H. Efficacy of quetiapine monotherapy in rapid-cycling bipolar disorder in comparison with sodium valproate. Journal of Clinical Psychopharmacology 2008, 28(5), 555-560.
Forsthoff AC, Grunze H, Seemueller F, Zetzsche T, Moeller HJ, Meisenzahl EM. In vivo effect of lithium on gray matter volume and relation to clinical outcome in bipolar patients. In: Bipolar Disorders: 3rd Biennial Conference of the International Society for Bipolar Disorders. 2008, New Delhi, India: Blackwell Publishing Ltd.
Post RM, Luckenbaugh DA, Leverich GS, Altshuler LL, Frye MA, Suppes T, Keck PE, McElroy SL, Nolen WA, Kupka R, Grunze H, Walden J. Incidence of childhood-onset bipolar illness in the USA and Europe. British Journal of Psychiatry 2008, 192(2), 150-151.
Severus E, Seemuller F, Grunze H, Obermeier N, Bernhard B, Ditimann S, Moeller HJ, Riedell M. Intravenous omega-3 fatty acids in the acute treatment of inpatients with bipolar depression. A pilot study. In: The International Journal of Neuropsychopharmacology: 26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP). 2008, Munich, Germany: Cambridge University Press.
Severus E, Seemuller F, Grunze H, Obermeier N, Bernhard B, Ditimann S, Moller HJ, Riedell M. Intravenous omega-3 fatty acids in the acute treatment of inpatients with bipolar depression. A pilot study. In: International Journal of Neuropsychopharmacology: 26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP). 2008, Munich, Germany: Cambridge University Press.
Kraemer S, Hundemer HP, Minarzyk A, Eberle E, Grunze H. Maintenance therapy in patients with bipolar disorder in German clinical routine practice - Which factors influence the adherence to primary treatment?. In: The International Journal of Neuropsychopharmacology: 26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP). 2008, Munich, Germany: Cambridge University Press.
Kraemer S, Hundemer HP, Minarzyk A, Eberle E, Grunze H. Maintenance therapy in patients with bipolar disorder in German clinical routine practice - Which factors influence the adherence to primary treatment?. In: International Journal of Neuropsychopharmacology: 26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP). 2008, Munich, Germany: Cambridge University Press.
Hegerl U, Bottner AC, Mergl R, Holtschmidt-Taschner B, Seemuller F, Scheunemann W, Schutze M, Grunze H, Henkel V, Angst J, Born C. Speed of onset of depressive episodes: a clinical criterion helpful for separating uni- from bipolar affective disorders. Neuropsychiatrie 2008, 22(2), 92-99.
Grunze H, Ghalib K. Suicidality and antidepressants. In: International Journal of Neuropsychopharmacology: 26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP). 2008, Munich, Germany: Cambridge University Press.
Grunze H. Switch to mania and antidepressants: the case for caution?. In: European Neuropsychopharmacology: 21st Congress of the European College of Neuropsychopharmacology. 2008, Barcelona, Spain: Elsevier BV.
Grunze H. Switch to mania and antidepressants: the case for caution?. In: European Neuropsychopharmacology: Papers of the 21st ECNP Congress. 2008, Barcelona, Spain: Elsevier.
Grunze H, Forsthoff A. The appropriate medication for bipolar depression - Is there any?. In: Bipolar Disorders: 3rd Biennial Conference of the International Society for Bipolar Disorders. 2008, New Delhi, India: Blackwell Publishing Ltd.
Dittmann S, Seemuller F, Grunze H, Schwartz MJ, Zach J, Fast K, Born C, Dargel S, Engel RR, Bernhard B, Moller HJ, Riedel M, Severus WE. The impact of homocysteine levels on cognition in euthymic bipolar patients: A cross-sectional study. Journal of Clinical Psychiatry 2008, 69(6), 899-906.
Tohen M, Bowden C, Calabrese J, Yatham L, Vieta E, Goodwin G, Frank E, Suppes T, Sachs G, Chengappa R, Grunze H, Mitchell P, Berk M, Kapczinski F, Ghaemi N, Malhi G, Nolen W, Colom F. The international society of bipolar disorders task force on the nomenclature of course and outcome in bipolar disorders. In: Bipolar Disorders: 3rd Biennial Conference of the International Society for Bipolar Disorders. 2008, New Delhi, India: Blackwell Publishing Ltd.
Gerber SI, Valerius G, Schaerer LO, Biedermann NC, Dittmann S, Grunze H, Langosch JM, Torrey EF, Yolken RH. The role of infectious agents on cognitive impairment in bipolar disorder. In: Acta Neuropsychiatrica: International Neuropsychiatric Pula Congress. 2008, Pula, Croatia: Blackwell Publishing Ltd.
Grunze H, Fountoulakis K. Treatment of acute bipolar depression. In: The International Journal of Neuropsychopharmacology: 26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP). 2008, Munich, Germany: Cambridge University Press.
Grunze H, Fountoulakis K. Treatment of acute bipolar depression. In: International Journal of Neuropsychopharmacology: 26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP). 2008, Munich, Germany: Cambridge University Press.
Grunze H, Klose N, Ibach B. Treatment of acute manic and mixed episodes in bipolar disorders. European Psychiatry 2008, 23(s2), S229.
Fountoulakis KN, Grunze H, Panagiotidis P, Kaprinis G. Treatment of bipolar depression: An update. Journal of Affective Disorders 2008, 109(1-2), 21-34.

Newcastle University

Institute of Neuroscience

Professor Heinz Grunze Prof of Clinical Psychiatry

Professor Heinz Grunze
Prof of Clinical Psychiatry