Newcastle University

Qualifications

B.Sc. Biology, University College London
Ph.D. Neurophysiology, University of Newcastle

Memberships

Society for Neuroscience

Understanding Animal Research 

Research Interests

I am interested in anaesthesia and analgesia of laboratory animals and how this affects the welfare of those animals.

Current Work

I am currently funded by the UK National Centre for the Replacement, Refinement and Reduction of Animals in Research to examine whether carbon dioxide is a humane euthanasia agent for laboratory rodents. I am using a range of behavioural techniques to examine whether animals exposed to carbon dioxide experience significant levels of stress or distress and whether alternative methods cause less stress.

Postgraduate Supervision

Shelley Rhodes (Ph.D 2009) - Evaluation of hypothermia for anaesthesia in neonatal rats, implications for animal welfare and experimental data

Funding Sources

Current;

National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs)

Universities Federation for Animal Welfare (UFAW)

Previous;

Pfizer Global Research and Development

The Johns Hopkins Center for Alternatives to Animal Testing

European College of Laboratory Animal Medicine

• Thomas AA, Flecknell PA, Golledge HDR. Combining Nitrous Oxide with Carbon Dioxide decreases the time to loss of consciousness during euthanasia in mice - refinement of animal welfare?. PLoS One 2012, 7(3), e32290.
• Golledge HDR, Lukic J, Flecknell PA. The effect of behavioural state and cage environment on responses to euthanasia with isoflurane or carbon dioxide in BALB/c mice. Altex 2012, 28, 246.
• Avlonitis VS, Wigfield CH, Golledge HDR, Rostron AJ, Kirby JA, Dark JH. Brain stem auditory evoked response for confirmation of brain death in the rat. Transplantation 2008, 86(5), 745-746.
• Reed B, Hawkins P, Latham N, Westwood K, Van Driel K, Battram C, Golledge H, Farmer A-M, Osborne N, Jennings M, Hubrecht R. Report of the 2006 RSPCA/UFAW Rodent Welfare Group meeting. In: Lab Animal. 2008, West Sussex: Nature Publishing Group.
• Avlonitis VS, Wigfield CH, Golledge HDR, Kirby JA, Dark JH. Early hemodynamic injury during donor brain death determines the severity of primary graft dysfunction after lung transplantation. American Journal of Transplantation 2007, 7(1), 83-90.
• Hawkins P, Playle L, Golledge H, Leach M, Banzett R, Coenen A, Cooper J, Danneman P, Flecknell P, Kirkden R, Niel L, Raj M. Newcastle Consensus Meeting on Carbon Dioxide Euthanasia of Laboratory Animals. Newcastle upon Tyne, UK:NC3Rs,2006.
• Antunes LM, Golledge HD, Roughan JV, Flecknell PA. Comparison of electroencephalogram activity and auditory evoked responses during isoflurane and halothane anaesthesia in the rat. Veterinary Anaesthesia and Analgesia 2003,30 1 15-23.
• Golledge HDR, Panzeri S, Zheng F, Pola G, Scannell JW, Giannikopoulos DV, Mason RJ, Tovee MJ, Young MP. Correlations, feature-binding and population coding in primary visual cortex. NeuroReport 2003,14 7 1045-1050.
• Wigfield CH, Golledge HDR, Shenton BK, Kirby JA, Dark JH. Ameliorated reperfusion injury in lung transplantation after reduction of brain death induced inflammatory graft damage in the donor. Journal of Heart and Lung Transplantation 2002, 21(1), 57.
• Gigg J, Golledge HDR, McDonald JS, Hurlbert AC, Tovee MJ. Neurons in marmoset V1 encode spatial cone-contrast. Perception 2002, 31(supplement), 67.
• Panzeri S, Golledge HDR, Zheng F, Pola G, Blanche TJ, Tovee MJ, Young MP. The role of correlated firing and synchrony in coding information about single and separate objects in cat V1. Neurocomputing 2002, 44-46, 579-584.
• Panzeri S, Golledge HDR, Zhang FS, Tovee MJ, Young MP. Objective assessment of the functional role of spike train correlations using information measures. Visual Cognition 2001, 8(3-5), 531-547.
• Schultz SR, Golledge HDR, Panzeri S. Synchronisation, Binding, and the Role of Correlated Firing in Fast Information Transmission. In: Wermter, S., Austin, J., Willshaw, D, ed. Emergent Neural Computational Architectures Based on Neuroscience: Towards Neuroscience-Inspired Computing. Berlin; New York: Springer, 2001, pp.212-226.
• Schultz SR, Golledge HDR, Panzeri S. Synchronisation, binding, and the role of correlated firing in fast information transmission. In: Wermter, S., Austin, J., Willshaw, D, ed. Emergent Neural Computational Architectures Based on Neuroscience: Towards Neuroscience-Inspired Computing. Berlin; New York: Springer, 2001, pp.212-226.
• Golledge HDR. Does inter-columnar neuronal synchrony play a role in visual feature binding? Ph.D. Thesis. Newcastle upon Tyne: University of Newcastle upon Tyne, 2000. Department of Psychology.
• F. Zheng,H. D. R. Golledge,D. V. Giannikopoulos,R. J. Mason,J. W. Scannell,M. J. Tovee,M. P. Young. Bimodal orientation and motion sensitivity in striate cortical neurons of anaesthetized cat. Journal of Physiology-London 1998, 509P, 58P-58P.
• H. D. R. Golledge,C. C. Hilgetag,M. J. Tovee. A solution to the binding problem?. Current Biology 1996, 6(9), 1092-1095.
• H. D. R. Golledge,C. C. Hilgetag,M. J. Tovee. Information processing: A solution to the binding problem?. Current Biology 1996, 6(9), 1092-1095.