Institute of Neuroscience

Staff Profile

Dr Jeremy Parr

Clinical Senior Lecturer/Hon Consultant

Background

Introduction

I am a Paediatric Neurodisability clinical academic with wide ranging research interests in the Neurodisability field, including investigating the neurobiological basis of disabilities, carrying out intervention studies to ameliorate disability, and undertaking research into clinical service delivery.

My clinical work is for two local NHS Trusts. 1. Newcastle Upon Tyne Hospitals NHS Foundation Trust at the Great North Children's Hospital in the Regional Neurodisability service (Regional Feeding clinic, and Neurodevelopmental Disorders Clinic) and 2.  Northumberland Tyne and Wear NHS Foundation Trust in the Regional Autism Spectrum Disorder diagnosis, management and intervention service, where I lead multidisciplinary assessments of children with ASD (the Complex Neurodevelopmental Disorders Service).

 

Qualifications 

MB ChB (1996)

MD (Broader Autism Phenotype, 2007)

CCT in Paediatric Neurodisability, and Paediatrics (2007) 

 

National committee roles

Member of the Executive Committee of the British Academy of Childhood Disability (2007-present)

Chair of the British Academy of Childhood Disability Strategic Research Group (2012-present)

Co-Chair of the Research Autism Scientific Advisory Committee (2012-present)

Member, the NIHR Medicines for Children Research Network Neurosciences Clinical Study Group (2013-present)

Trustee, The Castang Foundation (Member of the Castang Foundation Science Committee 2008-2014)

Member of the British Paediatric Neurology Association research committee (2013-present)

Member of the British Autism Study of Infant Siblings (BASIS) Science Committee (2012-present)

Expert adviser to The National Autism Project

Organising Committee member (lead for exhibition and sponsorship) and Scientific Committee member, The 25th European Academy of Childhood Disability (EACD) meeting, Newcastle-Gateshead, The Sage, Ocober 2013

 

Previous Positions

Nov 2006 – May 2009 Consultant and Honorary Senior Lecturer, Paediatric Neurodisability, Great Ormond Street Hospital and the Institute of Child Health, London

Sept 2008 – May 2009 Senior Academic Research Fellow and Honorary Consultant Paediatrician University of Oxford and Oxford Children’s Hospital

Research

As Chief Investigator

ASD-UK/Daslne

I lead the Autism Spectrum Database-UK, which is a database of families of children with ASD, who have shown interest in participating in research. The database has two main aims: 1. To increase families access to research; and 2. To increase the number of families available to be recruited to researchers studies, resulting in improved research capacity. ASD-UK was funded by the UK autism charity Autistica in 2010 (£145 000), and the integration with the regional North East database has been funded from 2014-17 (£225 000). More than 1900 families have now joined ASD-UK. Information for families and researchers can be found at http://www.asd-uk.com/.

Between the two databases, more than 3500 families can be contacted about research. We recently published two papers using information given to us by parents: The first is about the databases themselves (http://bmjopen.bmj.com/content/5/9/e008625.full.pdf+html) and the second about age of autism diagnosis in the UK (http://link.springer.com/article/10.1007/s10803-016-2716-6).


Autism Spectrum Lifecourse: Adulthood and Ageing

I lead a programme of research about the Autism Spectrum  in adulthood and older age that started to recruit adults and relatives to research cohorts in February 2015. In the first 12 months, more than 400 adults and 100 relatives joined the cohorts. This first part of the research programme is funded by Autistica (£200 000). Additional projects will commence in 2016. The first of these is around adult diagnosis and post diagnosis services (£170 000 from Autistica, and £30 000 from Northumberlnd Tyne and Wear NHS Foundation Trust). See https://research.ncl.ac.uk/adultautismspectrum/ for more information.


Clinical Trials

The Drooling Reduction Intervention Trial (DRI): I am Chief Investigator for a 15 site multicentre trial of the effectiveness of Glycopyrronium vs Hyoscine to treat drooling in children with neurodisability. Funding is from Wellchild (£57 000), the Castang Foundation (£60 000), The Children's Foundation (£21 000), and the British Academy of Childhood Disability (£25 000). We completed recruitment in March 2015 and the results will be available in 2016.


Virtual Reality Treatment for children with ASD and specific phobia: This is a collaboration with the company Third Eye. The initial project was funded through a Newcastle University sponsored Daphne Jackson Fellowship to Dr Morag Maskey (£42 000). The results of the study have been published and can be found here: http://www.ncl.ac.uk/ion/news/blueroom/

In February 2015, we started an NIHR Research for Patient Benefit funded project to investigate the treatment of children with ASD and phobia through two local NHS Trusts (£246 000). We completed recruitment in February 2016 - the results of the trial will be available in 2017.


The Dolphin Nutritional Intervention Trials: Together with Co PI Dr Peter Sullivan, I lead the Oxford Dolphin research studies. Follow up of the 100 children in the trial ended in February 2015 and the results will be available in 2016.

  • The effect of optimising nutrition on growth and neurodisability in children at risk of cerebral palsy  (£250 000 from the Castang Foundation)
  • The effect of optimising nutrition on growth and neurodisability in young children with confirmed cerebral palsy (£183 000 from SPARKS)

The follow up study of children in early childhood has recently started (£150 000 from the Castang Foundation)


Autism Genetics

Since 2011, I have led the International Molecular Genetic Study of Autism Consortium (IMGSAC). Data and family DNA are now housed in Newcastle. I lead IMGSACs role in the Autism Genome Project Consortium, a consortium of researchers from Europe and North America. The AGP aims to identify genetic casues of autism spectrum conditions, the relationship between genotype and autism spectrum phenotype, and the clinical application of these findings. Together with colleagues, I have led the investigation of the Broader Autism Phenotype in relatives of people with autism from the IMGSAC families

I work with a number of collaborators nationally and internationally on autism spectrum genetic studies (including on the UK10K project)


Other research I lead

The ASD+ study. This study has investigated the co existing conditions of children on the autism spectrum, and their impact on the family (through an Autistica Indian Fellowship, supporting Dr Beena Koshy; £88 000). Dr Koshy's study collected data from more than 650 parents of children on the autism spectrum - the first results from this study will be available in late 2016.


As Co Investigator 

I am part of a Newcastle led, multisite Research Programme regarding 'Transition'. This is a £2 million NIHR Programme grant for Applied Research, and is led by Professor Allan Colver (2012-2017). The Programme aims to answer the question: How can health services contribute most effectively to facilitating successful transition of young people with complex health needs from childhood to adulthood?

I am a member of the MeASURe group who have published a systematic review of measurement tools used to measure progress and outcome in young children in ASD (MeASURe: Measurement in Autism Spectrum Disorder Under Review). NIHR HTA, £271 000  (Chief Investigator Professor Helen McConachie, Newcastle University)

I am part of the Preschool Autism Communication Trial 7-11 follow up study (PACT 7-11) of children recruited to the MRC funded PACT study. This MRC funded  follow up study ended in early 2015 (£740 000, Chief Investigator Professor Jonathan Green, University of Manchester). I am also part of the group who will undertake a new PACT trial with older children, starting in 2016.

Dr Jacqui Rodgers lead a project to create a standardised measure of anxiety in children with ASD. Measuring anxiety in Autism Spectrum Disorder (£47 000, Baily Thomas Foundation). This study is complete and the research paper is now available.

Publications

  • Rodgers J, Wigham S, McConachie H, Freeston M, Honey E, Parr JR. Development of the Anxiety Scale for Children with autism spectrum disorder (ASC-ASD) Autism Research. Autism Research 2016, (ePub ahead of Print).
  • Farre A, Wood V, McDonagh JE, Parr J, Reape D, Rapley T. Health professionals’ and managers' definitions of developmentally appropriate healthcare for young people: conceptual dimensions and embedded controversies. Archives of Disease in Childhood 2016, epub ahead of print.
  • Warnell F, George B, McConachie H, Johnson M, Hardy R, Parr JR. Designing and recruiting to UK autism spectrum disorder research databases: do they include representative children with valid ASD diagnoses?. BMJ Open 2015, 5(9), e008625.
  • Farre A, Wood V, Rapley T, Parr J, Reape D, McDonagh JE. Developmentally Appropriate Healthcare for Young People: A Scoping Study. Archives of Disease in Childhood 2015, 100(2), 144-151.
  • Wood CL, Warnell F, Johnson M, Hames A, Pearce MS, McConachie H, Parr JR. Evidence for ASD Recurrence Rates and Reproductive Stoppage From Large UK ASD Research Family Databases. Autism Research 2015, 8(1), 73-81.
  • Parr J, Gray L, Wigham S, McConachie H, LeCouteur A. Measuring the relationship between the parental Broader Autism Phenotype, parent–child interaction, and children’s progress following parent mediated intervention. Research in Autism Spectrum Disorders 2015, 20, 24-30.
  • de Jonge M, Parr J, Rutter M, Wallace S, Kemner C, Bailey A, van Engeland H, Pickles A. New Interview and Observation Measures of the Broader Autism Phenotype: Group Differentiation. Journal of Autism and Developmental Disorders 2015, 45(4), 893-901.
  • O'Dushlaine C, Rossin L, Lee PH, Duncan L, Parikshak NN, Newhouse S, Ripke S, Neale BM, Purcell SM, Posthuma D, Nurnberger JI, Lee SH, Faraone SV, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayes M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DHR, Bloss CS, Boehnke M, Boomsma DI, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne EM, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Mattheisen M, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flicldnger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Friedl M, Frisen L, Gailagher L, Gejman PV, Georgieva L, Gershon ES, Giegling I, Gill M, Gordon SD, Gordon-Smith K, Green EK, Greenwood TA, Grice DE, Gross M, Grozeva D, Guan W, Gurling H, De Haan L, Haines JL, Hakonarson H, Hallmayer J, Hamilton SP, Hamshere ML, Hansen TF, Hartmann AM, Hautzinger M, Heath AC, Henders AK, Herms S, Hickie IB, Hipolito M, Hoefels S, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hultman CM, Hus V, Ingason A, Ising M, Jamain S, Jones EG, Jones I, Jones L, Tzeng JY, Kahler AK, Kahn RS, Kandaswamy R, Keller MC, Kennedy JL, Kenny E, Kent L, Kim YJ, Kirov GK, Klauck SM, Klei L, Knowles JA, Kohli MA, Koller DL, Konte B, Korszun A, Krabbendam L, Krasucki R, Kuntsi J, Kwan P, Landen M, Langstrom N, Lathrop M, Lawrence J, Lawson WB, Leboyer M, Ledbetter DH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu CY, Lohoff FW, Loo SK, Lord C, Lowe JK, Lucae S, MacIntyre DJ, Madden PAF, Maestrini E, Magnusson PKE, Mahon PB, Maier W, Malhotra AK, Mane SM, Martin CL, Martin NG, Matthews K, Mattingsdal M, McCarroll SA, McGhee KA, McGough JJ, McGrath PJ, McGuffin P, McInnis MG, McIntosh A, McKinney R, McLean AW, McMahon FJ, McMahon WM, McQuillin A, Medeiros H, Medland SE, Meier S, Melle I, Meng F, Meyer J, Middeldorp CM, Middleton L, Milanova V, Miranda A, Monaco AP, Montgomery GW, Moran JL, Moreno-De-Luca D, Morken G, Morris DW, Morrow EM, Moskvina V, Muglia P, Muhleisen TW, Muir WJ, Muller-Myhsok B, Murtha M, Myers RM, Myin-Germeys I, Neale MC, Nelson SF, Nievergelt CM, Nikolov I, Nimgaonkar V, Nolen WA, Nothen MM, Nwulia EA, Nyholt DR, Oades RD, Olincy A, Oliveira G, Olsen L, Ophoff RA, Osby U, Owen MJ, Palotie A, Parr JR, Paterson AD, Pato CN, Pato MT, Penninx BW, Pergadia ML, Pericak-Vance MA, Pickard BS, Pimm J, Piven J, Potash JB, Poustka F, Propping P, Puri V, Quested DJ, Quinn EM, Ramos-Quiroga JA, Rasmussen HB, Raychaudhuri S, Rehnstrom K, Reif A, Ribases M, Rice JP, Rietschel M, Roeder K, Roeyers H, Rothenberger A, Rouleau G, Ruderfer D, Rujescu D, Sanders AR, Sanders SJ, Santangelo SL, Sergeant JA, Schachar R, Schalling M, Schatzberg AF, Scheftner WA, Schellenberg GD, Scherer SW, Schork NJ, Schulze TG, Schumacher J, Schwarz M, Scolnick E, Scott LJ, Shi JX, Shilling PD, Shyn SI, Silverman JM, Slager SL, Smalley SL, Smit JH, Smith EN, Sonuga-Barke EJS, Cair DS, State M, Steffens M, Steinhausen HC, Strauss JS, Strohmaier J, Stroup TS, Sutdiffe JS, Szatmari P, Szelinger S, Thirumalai S, Thompson RC, Todorov AA, Tozzi F, Treutlein J, Uhr M, Van den Oord EJCG, Van Grootheest G, Van Os J, Vicente AM, Vieland VJ, Vincent JB, Visscher PM, Walsh CA, Wassink TH, Watson SJ, Weissman MM, Werge T, Wienker TF, Wijsman EM, Willemsen G, Williams N, Willsey AJ, Witt SH, Xu W, Young AH, Yu TW, Zammit S, Zandi PP, Zhang P, Zitman FG, Zollner S, Devlin B, Kelsoe JR, Sklar P, Daly MJ, O'Donovan MC, Craddock N, Kendler KS, Weiss LA, Wray NR, Zhao ZM, Geschwind DH, Sullivan PF, Smoller JW, Holmans PA, Breen G, IIBDGC, Network & Pathway Anal Subgrp Psyc. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience 2015, 18(2), 199-209.
  • McConachie HM, Parr J, Glod M, Hanratty J, Livingstone N, Oono IP, Robalino S, Baird GB, Beresford T, Charman T, Garland D, Green J, Gringras P, Jones G, Law J, Le Couteur AS, Macdonald G, McColl EM, Morris C, Rodgers J, Simonoff E, Terwee CB, Williams K. Systematic review of tools to measure outcomes for young children with autism spectrum disorder. Health Technology Assessment 2015, 19(41).
  • Walter K, Min JL, Huang J, Crooks L, Memari Y, McCarthy S, Perry JRB, Xu C, Futema M, Lawson D, Iotchkova V, Schiffels S, Hendricks AE, Danecek P, Li R, Floyd J, Wain LV, Barroso I, Humphries SE, Hurles ME, Zeggini E, Barrett JC, Plagnol V, Richards JB, Greenwood CMT, Timpson NJ, Durbin R, Soranzo N, Bala S, Clapham P, Coates G, Cox T, Daly A, Danecek P, Du Y, Durbin R, Edkins S, Ellis P, Flicek P, Guo X, Guo X, Huang L, Jackson DK, Joyce C, Keane T, Kolb-Kokocinski A, Langford C, Li Y, Liang J, Lin H, Liu R, Maslen J, McCarthy S, Muddyman D, Quail MA, Stalker J, Sun J, Tian J, Wang G, Wang J, Wang Y, Wong K, Zhang P, Barroso I, Birney E, Boustred C, Chen L, Clement G, Cocca M, Danecek P, Smith GD, Day INM, Day-Williams A, Down T, Dunham I, Durbin R, Evans DM, Gaunt TR, Geihs M, Greenwood CMT, Hart D, Hendricks AE, Howie B, Huang J, Hubbard T, Hysi P, Iotchkova V, Jamshidi Y, Karczewski KJ, Kemp JP, Lachance G, Lawson D, Lek M, Lopes M, MacArthur DG, Marchini J, Mangino M, Mathieson I, McCarthy S, Memari Y, Metrustry S, Min JL, Moayyeri A, Muddyman D, Northstone K, Panoutsopoulou K, Paternoster L, Perry JRB, Quaye L, Richards JB, Ring S, Ritchie GRS, Schiffels S, Shihab HA, Shin SY, Small KS, Artigas MS, Soranzo N, Southam L, Spector TD, St Pourcain B, Surdulescu G, Tachmazidou I, Timpson NJ, Tobin MD, Valdes AM, Visscher PM, Wain LV, Walter K, Ward K, Wilson SG, Wong K, Yang J, Zeggini E, Zhang F, Zheng HF, Anney R, Ayub M, Barrett JC, Blackwood D, Bolton PF, Breen G, Collier DA, Craddock N, Crooks L, Curran S, Curtis D, Durbin R, Gallagher L, Geschwind D, Gurling H, Holmans P, Lee I, Lonnqvist J, McCarthy S, McGuffin P, McIntosh AM, McKechanie AG, McQuillin A, Morris J, Muddyman D, O'Donovan MC, Owen MJ, Palotie A, Parr JR, Paunio T, Pietilainen O, Rehnstrom K, Sharp SI, Skuse D, St Clair D, Suvisaari J, Walters JTR, Williams HJ, Barroso I, Bochukova E, Bounds R, Dominiczak A, Durbin R, Farooqi IS, Hendricks AE, Keogh J, Marenne GL, McCarthy S, Morris A, Muddyman D, O'Rahilly S, Porteous DJ, Smith BH, Tachmazidou I, Wheeler E, Zeggini E, Al Turki S, Anderson CA, Antony D, Barroso IS, Beales P, Bentham J, Bhattacharya S, Calissano M, Carss K, Chatterjee K, Cirak S, Cosgrove C, Durbin R, Fitzpatrick DR, Floyd J, Foley AR, Franklin CS, Futema M, Grozeva D, Humphries SE, Hurles ME, McCarthy S, Mitchison HM, Muddyman D, Muntoni F, O'Rahilly S, Onoufriadis A, Parker V, Payne F, Plagnol V, Raymond FL, Roberts N, Savage DB, Scambler P, Schmidts M, Schoenmakers N, Semple RK, Serra E, Spasic-Boskovic O, Stevens E, van Kogelenberg M, Vijayarangakannan P, Walter K, Williamson KA, Wilson C, Whyte T, Ciampi A, Greenwood CMT, Hendricks AE, Li R, Metrustry S, Oualkacha K, Tachmazidou I, Xu CJ, Zeggini E, Bobrow M, Bolton PF, Durbin R, Fitzpatrick DR, Griffin H, Hurles ME, Kaye J, Kennedy K, Kent A, Muddyman D, Muntoni F, Raymond FL, Semple RK, Smee C, Spector TD, Timpson NJ, Charlton R, Ekong R, Futema M, Humphries SE, Khawaja F, Lopes LR, Migone N, Payne SJ, Plagnol V, Pollitt RC, Povey S, Ridout CK, Robinson RL, Scott RH, Shaw A, Syrris P, Taylor R, Vandersteen AM, Barrett JC, Barroso I, Smith GD, Durbin R, Farooqi IS, Fitzpatrick DR, Hurles ME, Kaye J, Kennedy K, Langford C, McCarthy S, Muddyman D, Owen MJ, Palotie A, Richards JB, Soranzo N, Spector TD, Stalker J, Timpson NJ, Zeggini E, Amuzu A, Casas JP, Chambers JC, Cocca M, Dedoussis G, Gambaro G, Gasparini P, Gaunt TR, Huang J, Iotchkova V, Isaacs A, Johnson J, Kleber ME, Kooner JS, Langenberg C, Luan J, Malerba G, Marz W, Matchan A, Min JL, Morris R, Nordestgaard BG, Benn M, Ring S, Scott RA, Soranzo N, Southam L, Timpson NJ, Toniolo D, Traglia M, Tybjaerg-Hansen A, van Duijn CM, van Leeuwen EM, Varbo A, Whincup P, Zaza G, Zeggini E, Zhang WH, UK10K Consortium, UCLEB Consortium. The UK10K project identifies rare variants in health and disease. Nature 2015, 526(7571), 82-90.
  • Pinto D, Delaby E, Merico D, Barbosa M, Merikangas A, Klei L, Thiruvahindrapuram B, Xu X, Ziman R, Wang ZZ, Vorstman JAS, Thompson A, Regan R, Pilorge M, Pellecchia G, Pagnamenta AT, Oliveira B, Marshall CR, Magalhaes TR, Lowe JK, Howe JL, Griswold AJ, Gilbert J, Duketis E, Dombroski BA, De Jonge MV, Cuccaro M, Crawford EL, Correia CT, Conroy J, Conceicao IC, Chiocchetti AG, Casey JP, Cai G, Cabrol C, Bolshakova N, Bacchelli E, Anney R, Gallinger S, Cotterchio M, Casey G, Zwaigenbaum L, Wittemeyer K, Wing K, Wallace S, van Engeland H, Tryfon A, Thomson S, Soorya L, Roge B, Roberts W, Poustka F, Mouga S, Minshew N, McInnes LA, McGrew SG, Lord C, Leboyer M, Le Couteur AS, Kolevzon A, Gonzalez PJ, Jacob S, Holt R, Guter S, Green J, Green A, Gillberg C, Fernandez BA, Duque F, Delorme R, Dawson G, Chaste P, Cafe C, Brennan S, Bourgeron T, Bolton PF, Bolte S, Bernier R, Baird G, Bailey AJ, Anagnostou E, Almeida J, Wijsman EM, Vieland VJ, Vicente AM, Schellenberg GD, Pericak-Vance M, Paterson AD, Parr JR, Oliveira G, Nurnberger JI, Monaco AP, Maestrini E, Klauck SM, Hakonarson H, Haines JL, Geschwind DH, Freitag CM, Folstein SE, Ennis S, Coon H, Battaglia A, Szatmari P, Sutcliffe JS, Hallmayer J, Gill M, Cook EH, Buxbaum JD, Devlin B, Gallagher L, Betancur C, Scherer SW. Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders. American Journal of Human Genetics 2014, 94(5), 677-694.
  • South M, Chamberlain PD, Wigham S, Newton T, Le Couteur A, McConachie H, Gray L, Freeston M, Parr J, Kirwan CB, Rodgers J. Enhanced decision making and risk avoidance in high-functioning autism spectrum disorder. Neuropsychology 2014, 28(2), 222-228.
  • Ceroni F, Simpson NH, Francks C, Baird G, Conti-Ramsden G, Clark A, Bolton PF, Hennessy ER, Donnelly P, Bentley DR, Martin H, IMGSAC, SLI Consortium, WGS500 Consortium, Parr J, Pagnamenta AT, Maestrini E, Bacchelli E, Newbury DF, Fisher SE. Homozygous microdeletion of exon 5 in ZNF277 in a girl with specific language impairment. European Journal of Human Genetics 2014, 22(10), 1165-1171.
  • Winburn E, Charlton J, McConachie H, McColl E, Parr J, O'Hare A, Baird G, Gringras P, Wilson DC, Adamson A, Adams S, Le Couteur A. Parents' and Child Health Professionals' Attitudes Towards Dietary Interventions for Children with Autism Spectrum Disorders. Journal of Autism and Developmental Disorders 2014, 44(4), 747-757.
  • Maskey M, Lowry J, Rodgers J, McConachie H, Parr J. Reducing specific phobia/fear in young people with autism spectrum disorders (ASDs) through a virtual reality environment intervention. PLoS ONE 2014, 9(7), e100374.
  • De Rubeis S, He X, Goldberg AP, Poultney CS, Samocha K, Cicek AE, Kou Y, Liu L, Fromer M, Walker S, Singh T, Klei L, Kosmicki J, Fu SC, Aleksic B, Biscaldi M, Bolton PF, Brownfeld JM, Cai JL, Campbell NG, Carracedo A, Chahrour MH, Chiocchetti AG, Coon H, Crawford EL, Crooks L, Curran SR, Dawson G, Duketis E, Fernandez BA, Gallagher L, Geller E, Guter SJ, Hill RS, Ionita-Laza I, Gonzalez PJ, Kilpinen H, Klauck SM, Kolevzon A, Lee I, Lei J, Lehtimaki T, Lin CF, Ma'ayan A, Marshall CR, McInnes AL, Neale B, Owen MJ, Ozaki N, Parellada M, Parr JR, Purcell S, Puura K, Rajagopalan D, Rehnstrom K, Reichenberg A, Sabo A, Sachse M, Sanders SJ, Schafer C, Schulte-Ruther M, Skuse D, Stevens C, Szatmari P, Tammimies K, Valladares O, Voran A, Wang LS, Weiss LA, Willsey AJ, Yu TW, Yuen RKC, Cook EH, Freitag CM, Gill M, Hultman CM, Lehner T, Palotie A, Schellenberg GD, Skiar P, State MW, Sutcliffe JS, Walsh CA, Scherer SW, Zwick ME, Barrett JC, Cutler DJ, Roeder K, Devlin B, Daly MJ, Buxbaum JD, DDD Study, Homozygosity Mapping Collaborative, UK10K Consortium, Autism Sequencing Consortium. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 2014, 515(7526), 209-U119.
  • Parr JR, Weldon E, Pennington L, Steen N, Williams J, Fairhurst C, O'Hare A, Lodh R, Colver A. The drooling reduction intervention trial (DRI): a single blind trial comparing the efficacy of glycopyrronium and hyoscine on drooling in children with neurodisability. Trials 2014, 15(60).
  • Maskey M, Warnell F, Parr J, LeCouteur A, McConachie H. Emotional and Behavioural Problems in Children with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders 2013, 43(4), 851-859.
  • Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayes M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DHR, Bloss CS, Boehnke M, Boomsma DI, Breen G, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne EM, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan JB, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Friedl M, Frisen L, Gallagher L, Gejman PV, Georgieva L, Gershon ES, Geschwind DH, Giegling I, Gill M, Gordon SD, Gordon-Smith K, Green EK, Greenwood TA, Grice DE, Gross M, Grozeva D, Guan WH, Gurling H, De Haan L, Haines JL, Hakonarson H, Hallmayer J, Hamilton SP, Hamshere ML, Hansen TF, Hartmann AM, Hautzinger M, Heath AC, Henders AK, Herms S, Hickie IB, Hipolito M, Hoefels S, Holmans PA, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hultman CM, Hus V, Ingason A, Ising M, Jamain S, Jones EG, Jones I, Jones L, Tzeng JY, Kahler AK, Kahn RS, Kandaswamy R, Keller MC, Kennedy JL, Kenny E, Kent L, Kim Y, Kirov GK, Klauck SM, Klei L, Knowles JA, Kohli MA, Koller DL, Konte B, Korszun A, Krabbendam L, Krasucki R, Kuntsi J, Kwan P, Landen M, Langstrom N, Lathrop M, Lawrence J, Lawson WB, Leboyer M, Ledbetter DH, Lee PH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu CY, Lohoff FW, Loo SK, Lord C, Lowe JK, Lucae S, MacIntyre DJ, Madden PAF, Maestrini E, Magnusson PKE, Mahon PB, Maier W, Malhotra AK, Mane SM, Martin CL, Martin NG, Mattheisen M, Matthews K, Mattingsdal M, McCarroll SA, McGhee KA, McGough JJ, McGrath PJ, McGuffin P, McInnis MG, McIntosh A, McKinney R, McLean AW, McMahon FJ, McMahon WM, McQuillin A, Medeiros H, Medland SE, Meier S, Melle I, Meng F, Meyer J, Middeldorp CM, Middleton L, Milanova V, Miranda A, Monaco AP, Montgomery GW, Moran JL, Moreno-De-Luca D, Morken G, Morris DW, Morrow EM, Moskvina V, Muglia P, Muhleisen TW, Muir WJ, Muller-Myhsok B, Murtha M, Myers RM, Myin-Germeys I, Neale MC, Nelson SF, Nievergelt CM, Nikolov I, Nimgaonkar V, Nolen WA, Nothen MM, Nurnberger JI, Nwulia EA, Nyholt DR, O'Dushlaine C, Oades RD, Olincy A, Oliveira G, Olsen L, Ophoff RA, Osby U, Owen MJ, Palotie A, Parr JR, Paterson AD, Pato CN, Pato MT, Penninx BW, Pergadia ML, Pericak-Vance MA, Pickard BS, Pimm J, Piven J, Posthuma D, Potash JB, Poustka F, Propping P, Puri V, Quested DJ, Quinn EM, Ramos-Quiroga JA, Rasmussen HB, Raychaudhuri S, Rehnstrom K, Reif A, Ribases M, Rice JP, Rietschel M, Roeder K, Roeyers H, Rossin L, Rothenberger A, Rouleau G, Ruderfer D, Rujescu D, Sanders AR, Sanders SJ, Santangelo SL, Sergeant JA, Schachar R, Schalling M, Schatzberg AF, Scheftner WA, Schellenberg GD, Scherer SW, Schork NJ, Schulze TG, Schumacher J, Schwarz M, Scolnick E, Scott LJ, Shi JX, Shilling PD, Shyn SI, Silverman JM, Slager SL, Smalley SL, Smit JH, Smith EN, Sonuga-Barke EJS, St Clair D, State M, Steffens M, Steinhausen HC, Strauss JS, Strohmaier J, Stroup TS, Sutcliffe JS, Szatmari P, Szelinger S, Thirumalai S, Thompson RC, Todorov AA, Tozzi F, Treutlein J, Uhr M, van den Oord EJCG, Van Grootheest G, Van Os J, Vicente AM, Vieland VJ, Vincent JB, Visscher PM, Walsh CA, Wassink TH, Watson SJ, Weissman MM, Werge T, Wienker TF, Wijsman EM, Willemsen G, Williams N, Willsey AJ, Witt SH, Xu W, Young AH, Yu TW, Zammit S, Zandi PP, Zhang P, Zitman FG, Zollner S, Devlin B, Kelsoe JR, Sklar P, Daly MJ, O'Donovan MC, Craddock N, Sullivan PF, Smoller JW, Kendler KS, Wray NR, Cross-Disorder Group Psychiatric Genomics Consortium, Int Inflammatory Bowel Dis Genetic. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 2013, 45(9), 984-994.
  • Colver AF, Merrick H, Deverill M, Lecouteur A, Parr J, Pearce MS, Rapley T, Vale L, Watson R, McConachie H, on behalf of the Transition Collaborative Group. Study protocol: longitudinal study of the transition of young people with complex health needs from child to adult health services. BMC Public Health 2013, 13(1), 675.
  • Parr J, Jolleff N, Gray L, Gibbs J, Williams J, McConachie H. Twenty years of research shows UK child development team provision still varies widely for children with disability. Child: Care, Health and Development 2013, 39(6), 903-907.
  • Anney R, Klei L, Pinto D, Almeida J, Bacchelli E, Baird G, Bolshakova N, Bolte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Casey J, Conroy J, Correia C, Corsello C, Crawford EL, de Jonge M, Delorme R, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Gilbert J, Gillberg C, Glessner JT, Green A, Green J, Guter SJ, Heron EA, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Jacob S, Kenny GP, Kim C, Kolevzon A, Kustanovich V, Lajonchere CM, Lamb JA, Law-Smith M, Leboyer M, Le Couteur A, Leventhal BL, Liu XQ, Lombard F, Lord C, Lotspeich L, Lund SC, Magalhaes TR, Mantoulan C, McDougle CJ, Melhem NM, Merikangas A, Minshew NJ, Mirza GK, Munson J, Noakes C, Nygren G, Papanikolaou K, Pagnamenta AT, Parrini B, Paton T, Pickles A, Posey DJ, Poustka F, Ragoussis J, Regan R, Roberts W, Roeder K, Roge B, Rutter ML, Schlitt S, Shah N, Sheffield VC, Soorya L, Sousa I, Stoppioni V, Sykes N, Tancredi R, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Vorstman JAS, Wallace S, Wing K, Wittemeyer K, Wood S, Zurawiecki D, Zwaigenbaum L, Bailey AJ, Battaglia A, Cantor RM, Coon H, Cuccaro ML, Dawson G, Ennis S, Freitag CM, Geschwind DH, Haines JL, Klauck SM, McMahon WM, Maestrini E, Miller J, Monaco AP, Nelson SF, Nurnberger JI, Oliveira G, Parr JR, Pericak-Vance MA, Piven J, Schellenberg GD, Scherer S, Vicente AM, Wassink TH, Wijsman EM, Betancur C, Buxbaum JD, Cook EH, Gallagher L, Gill M, Hallmayer J, Paterson AD, Sutcliffe JS, Szatmari P, Vieland VJ, Hakonarson H, Devlin B. Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Human Molecular Genetics 2012, 21(21), 4781-4792.
  • Parr JR, Buswell CA, Banerjee K, Fairhurst C, Williams J, OHare A, Pennington L. Management of drooling in children: a survey of UK paediatricians' clinical practice. Child: Care, Health and Development 2012, 38(2), 287-291.
  • Palmer E, Ketteridge C, Parr JR, Baird G, LeCouteur A. Autism spectrum disorder diagnostic assessments: improvements since publication of the National Autism Plan for Children. Archives of Disease in Childhood 2011, 96(5), 473-475.
  • Parr J, Wittemeyer K, LeCouteur A. Commentary: The Broader Autism Phenotype Implications for Research & Clinical Practice. In: Amaral, D., Geschwind, D., Dawson, G, ed. Autism Spectrum Disorders. New York, USA: Oxford University Press, 2011, pp.521-524.
  • Absoud M, Parr JR, Salt A, Dale N. Developing a schedule to identify social communication difficulties and autism spectrum disorder in young children with visual impairment. Developmental Medicine and Child Neurology 2011, 53(3), 285-288.
  • Anney RJ, Kenny EM, ODushlaine C, Yaspan BL, Parkhomenka E, Buxbaum JD, Sutcliffe J, Gill M, Gallagher L, Bailey AJ, Fernandez BA, Szatmari P, Scherer SW, Patterson A, Marshall CR, Pinto D, Vincent JB, Fombonne E, Betancur C, Delorme R, Leboyer M, Bourgeron T, Mantoulan C, Roge B, Tauber M, Freitag CM, Poustka F, Duketis E, Klauck SM, Poustka A, Papanikolaou K, Tsiantis J, Gallagher L, Gill M, Anney R, Bolshakova N, Brennan S, Hughes G, McGrath J, Merikangas A, Ennis S, Green A, Casey JP, Conroy JM, Regan R, Shah N, Maestrini E, Bacchelli E, Minopoli F, Stoppioni V, Battaglia A, Igliozzi R, Parrini B, Tancredi R, Oliveira G, Almeida J, Duque F, Vicente A, Correia C, Magalhaes TR, Gillberg C, Nygren G, Jonge MD, VanEngeland H, Vorstman JA, Wittemeyer K, Baird G, Bolton PF, Rutter ML, Green J, Lamb JA, Pickles A, Parr JR, Couteur AL, Berney T, McConachie H, Wallace S, Coutanche M, Foley S, White K, Monaco AP, Holt R, Farrar P, Pagnamenta AT, Mirza GK, Ragoussis J, Sousa I, Sykes N, Wing K, Hallmayer J, Cantor RM, Nelson SF, Geschwind DH, Abrahams BS, Volkmar F, PericakVance MA, Cuccaro ML, Gilbert J, Cook EH, Guter SJ, Jacob S, Nurnberger JI, McDougle CJ, Posey DJ, Lord C, Corsello C, Hus V, Buxbaum JD, Kolevzon A, Soorya L, Parkhomenko E, Leventhal BL, Dawson G, Vieland VJ, Hakonarson H, Glessner JT, Kim C, Wang K, Schellenberg GD, Devlin B, Klei L, Minshew N, Sutcliffe JS, Haines JL, Lund SC, Thomson S, Yaspan BL, Coon H, Miller J, McMahon WM, Munson J, Estes A, Wijsman EM. Gene-ontology enrichment analysis in two independent family-based samples highlights biologically palusible processes for autism spectrum disorder. European Journal of Human Genetics 2011, 19(10), 1082-1089.
  • Watson R, Parr J, Joyce C, May C, LeCouteur A. Models of transitional care for young people with complex health needs: a scoping review. Child: Care, Health and Development 2011, 37(6), 780-791.
  • Vieland VJ, Hallmayer J, Huang Y, Pagnamenta AT, Pinto D, Khan H, Monaco AP, Paterson AD, Scherer SW, Sutcliffe JS, Szatmari P, Parr JR. Novel method for combined likage and genome-wide association analysis finds evidence of distinct genetic architecture for two subtypes of autism. Journal of Neurodevelopmental Disorders 2011, 3(2), 113-123.
  • Gray L, Ansell P, Baird G, Parr JR. The continuing challenge of diagnosing autism spectrum disorder in children with Down syndrome. Child: Care, Health and Development 2011, 37(4), 459-461.
  • Parr J, Le Couteur A. What is the Broader Autism Phenotype?. In: Bolte, S., Hallmayer, J, ed. Autism Spectrum Conditions: FAQs on Autism, Asperger Syndrome, and Atypical Autism Answered by International Experts. Cambridge, Massachusetts, USA: Hogrefe Publishing, 2011, pp.521-524.
  • Anney R, Klei L, Pinto D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Sykes N, Pagnamenta AT, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bolte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Carson AR, Casallo G, Casey J, Chu SH, Cochrane L, Corsello C, Crawford EL, Crossett A, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Goldberg J, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal BL, Lionel AC, Liu XQ, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Melhem NM, Merikangas A, Migita O, Minshew NJ, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Piven J, Osey DJ, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, Salt J, Sansom K, Sato D, Segurado R, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang ZZ, Wassink TH, Wing K, Wittemeyer K, Wood S, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Betancur C, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Gallagher L, Geschwind DH, Gill M, Haines JL, Miller J, Monaco AP, Nurnberger JI, Paterson AD, Pericak-Vance MA, Schellenberg GD, Scherer SW, Sutcliffe JS, Szatmari P, Vicente AM, Vieland VJ, Wijsman EM, Devlin B, Ennis S, Hallmayer J. A genome-wide scan for common alleles affecting risk for autism. Human Molecular Genetics 2010, 19(20), 4072-4082.
  • Pagnamenta AT, Bacchelli E, de Jonge MV, Mirza G, Scerri TS, Minopoli F, Chiocchetti A, Ludwig KU, Hoffmann P, Paracchini S, Lowy E, Harold DH, Chapman JA, Klauck SM, Poustka F, Houben RH, Staal WG, Ophoff RA, O'Donovan MC, Williams J, Northen MM, Schulte Korne G, Deloukas P, Ragoussis J, Bailey AJ, Maestrini E, Monaco AP, International Molecular Genetic Study Of Autism Consortium. Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biological Psychiatry 2010, 68(4), 320-328.
  • Parr JR, Jayawant S, Buckley C, Vincent A. Childhood autoimmune myasthenia. In: Dale, R.C., Vincent, A, ed. Inflammatory and Autoimmune Disorders of the Nervous System in Children. London: MacKeith Press, 2010, pp.388-405.
  • Noor A, Whibley A, Marshall CR, Gianakopoulos PJ, Piton A, Carson AR, Orlic Milacic M, Lionel AC, Sato D, Pinto D, Drmic I, Noakes C, Senman L, Zhang X, Mo R, Gauthier J, Crosbie J, Pagnamenta AT, Munson J, Estes AM, Fiebig A, Franke A, Schreiber S, Stewart AF, Roberts R, McPherson R, Guter SJ, Cook EH, Dawson G, Schellenberg GD, Battaglia A, Maestrini E, Jeng L, Hutchison T, RajcanSeparovic E, Chudley AE, Lewis SM, Liu X, HOlden JJ, Fernandez B, Zwaigenbaum L, Bryson SE, Roberts W, Szatmari P, Gallagher L, Stratton MR, Gecz J, Brady AF, Schwartz CE, Schachar RJ, Monaco AP, Rouleau GA, Hui CC, Lucy RF, Scherer SW, Vincent JB, Autism Genome Project Consortium. Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. Science Translational Medicine 2010, 2(49), 68.
  • Parr J, Le Couteur A, Baird G, Rutter M, Pickles A, Fombonne E, Bailey A. Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample. Journal of Autism and Developmental Disorders 2010, 41(3), 332-340.
  • Wallace S, Sebastian C, Pellicano E, Parr J, Bailey A. Face Processing Abilities in Relatives of Individuals With ASD. Autism Research 2010, 3(6), 345-349.
  • Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Berney T, Le Couteur A, McConachie H, Parr JR. Functional impact of global rare copy number variation in autism spectrum disorders. Nature 2010, 466, 368–372.
  • Maestrini E, Pagnamenta AT, Lamb JA, Bacchelli E, Sykes NH, Sousa I, Toma C, Barnby G, Butler H, Winchester L, Scerri TS, Minopoli F, Reichert J, Cai G, Buxbaum JD, Korvatska O, Schellenberg GD, Dawson G, deBildt A, Minderaa RB, Mulder EJ, Morris AP, Bailey AJ, Monaco AP, IMGSAC. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. Molecular Psychiatry 2010, 15(9), 954-968.
  • Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder E, Kantojarvi K, Jarvela I, Klauck SM, Poustka F, Bailey AJ, Monaco AP, The International Molecular Genetic Study of Autism Consortium, Newcastle Site: Le Couteur, A. Principal Investigator. Linkage and Candidate Gene Studies of Autism Spectrum Disorders in European Populations. European Journal of Human Genetics 2010, 18(9), 1013-1019.
  • Sousa I, Clark TG, Holt R, Pagnamenta AT, Mulder EJ, Minderaa RB, Bailey AJ, Battaglia A, Klauck SM, Poustka F, Monaco AP, International Molecular Genetic Study of Autism Consortium (IMGSAC). Polymophisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry. Molecular Autism 2010, 1(1), 7.
  • Parr JR, Dale NJ, Shaffer LM, Salt AT. Social communication difficulties and autism spectrum disorder in young children with optic nerve hypoplasia and/or septo-optic dysplasia. Developmental Medicine and Child Neurology 2010, 52(10), 917-921.
  • Pagnamenta AT, Wing K, Sadighi AE, Knight SJ, Bolte S, Schmotzer G, Duketis E, Poustka F, Klauck SM, Poustka A, Ragoussis J, Bailey AJ, Monaco AP, International Molecular Genetic Study of Autism Consortium (IMGSAC). A 15q13.3 microdeletion segregating with autism. European Journal of Human Genetics 2009, 17(5), 687-692.
  • Absoud M, Parr J, Pretorius P, Zaiwalla Z, Jayawant S. A novel ARX phenotype: Rapid neurodegeneration with Ohtahara Syndrome and a dyskinetic movement disorder. Developmental Medicine and Child Neurology 2009, 52(3), 305-307.
  • Parr JR. BMJ Best Practice: Autism. London: British Medical Journal, 2009. Available at: http://bestpractice.bmj.com/best-practice/monograph/379.html.
  • Parr JR. BMJ Point of Care: Autism. London: British Medical Journal, 2009.
  • Sykes NH, Toma C, Wilson N, Volpi EV, Sousa I, Pagnamenta AT, Tancredi R, Battaglia A, Maestrini E, Bailey AJ, Monaco AP, International Molecular Genetic Study of Autism Consortium (IMGSAC). Copy number variation and association analysis of SHANK3 as a candidate gene for autism in the IMGSAC collection. European Journal of Human Genetics 2009, 17, 1347-1353.
  • Weiss LA, Arking DE, McConachie H. Letter: A genome-wide linkage and association scan reveals novel loci for autism. Nature 2009, 461, 802-808.
  • Sousa I, Clark TG, Kobayashi K, Choma M, Holt R, Sykes NH, Lamb JA, Bailey AJ, Battaglia A, Maestrini E, Monaco AP, International Molecular Genetic Study of Autism Consortium (IMGSAC). MET and autism susceptibility: family and case-control studies. European Journal of Human Genetics 2009, 17(6), 749-758.
  • Gong X, Bacchelli E, Blasi F, Toma C, Betancur C, Chaste P, Delorme R, Durand CM, Fauchereau F, Botros HG, Leboyer M, Mouren-Simeoni M-C, Nygren G, Anckarsäter H, Rastam M, Gillberg IC, Gillberg C, Moreno-De-Luca D, Carone S, Nummela I, Rossi M, Battaglia A, The International Molecular Genetic Study of Autism Consortium (IMGSAC), Jarvela I, Maestrini E, Bourgeron T. Analysis of X chromosome inactivation in autism spectrum disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2008, 147B(6), 830-835.
  • Parr JR. Autism. UK: BMJ Group, 2008.
  • Liu XQ, Paterson AD, Szatmaric P, Autism Genome Project Consortium. Genome-wide linkage analyses of quantitative and categorical autism subphenotypes. Biological Psychiatry 2008, 64(7), 561-570.
  • Lang TF, Parr JR, Matthews EE, Gray RG, Bonham JR, Kay JD. Practical difficulties in the diagnosis of transient non-ketotic hyperglycinaemia. Developmental Medicine and Child Neurology 2008, 50(2), 175-179.
  • Andrew M, Parr JR, Stacey R, Hart Y, Pretorius P, Nijhawan S, Zaiwalla Z, Rosenfeld JV, McShane MA. Transcallosal Resection of Hypothalamic Hamartoma in Children with Gelastic Seizures. Child's Nervous System 2008, 24(2), 275-279.
  • Parr JR. Autism. Clinical Evidence 2007, 0322.
  • Parr JR, Jayawant S. Childhood myasthenia: Clinical subtypes and practical management. Developmental Medicine and Child Neurology 2007, 49(8), 629-635.
  • Parr JR, Green A, Joint C, Andrew M, Gregory R, Scott R, McShane MA, Aziz T. Deep Brain Stimulation in childhood: An effective treatment for Idiopathic Dystonia. Archives of Disease in Childhood 2007, 92(8), 708-711.
  • Toma C, Rossi M, Sousa I, Blasi F, Bacchelli E, Alen R, Vanhala R, Monaco AP, Jarveka I, Maestrini E, IMGSAC. Is ASMT a susceptibility gene for autism spectrum disorders?. Molecular Psychiatry 2007, 12(11), 977-979.
  • Morten K, Ashley N, Wijburg F, Hadzic N, Parr JR, Jayawant S, Adams S, Bindoff L, Bakker H, Mieli-Vergani G, Poulton J. Liver mtDNA content increases during development: A comparison of the methods and the importance of age and tissue specific controls for the diagnosis of mtDNA depletion. Mitochondrion 2007, 7(6), 386-395.
  • Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, Liu X-Q, Vincent JB, Skaug JL, Thompson AP, Senman L, Feuk L, Qian C, Bryson SE, Jones MB, Marshall CR, Scherer SW, Vieland VJ, Bartlett C, Mangin LV, Goedken R, Segre A, Pericak-Vance MA, Cuccaro ML, Gilbert JR, Wright HH, Abramson RK, Betancur C, Bourgeron T, Gillberg C, Leboyer M, Buxbaum JD, Davis KL, Hollander E, Silverman JM, Hallmayer J, Lotspeich L, Sutcliffe JS, Haines JL, Folstein SE, Piven J, Wassink TH, Sheffield V, Geschwind DH, Bucan M, Brown WT, Cantor RM, Constantino JN, Gilliam TC, Herbert M, LaJonchere C, Ledbetter DH, Lese-Martin C, Miller J, Nelson S, Samango-Sprouse CA, Spence S, State M, Tanzi RE, Coon H, Dawson G, Devlin B, Estes A, Flodman P, Klei L, McMahon WM, Minshew N, Munson J, Korvatska E, Rodier PM, Schellenberg GD, Smith M, Spence MA, Stodgell C, Tepper PG, Wijsman EM, Yu C-E, Roge B, Mantoulan C, Wittemeyer K, Poustka A, Felder B, Klauck SM, Schuster C, Poustka F, Bolte S, Feineis-Matthews S, Herbrecht E, Schmotzer G, Tsiantis J, Papanikolaou K, Maestrini E, Bacchelli E, Blasi F, Carone S, Toma C, Van Engeland H, De Jonge M, Kemner C, Koop F, Langemeijer M, Hijimans C, Staal WG, Baird G, Bolton PF, Rutter ML, Weisblatt E, Green J, Aldred C, Wilkinson J-A, Pickles A, Le Couteur A, Berney T, McConachie H, Bailey AJ, Francis K, Honeyman G, Hutchinson A, Parr JR, Wallace S, Monaco AP, Barnby G, Kobayashi K, Lamb JA, Sousa I, Sykes N, Cook EH, Guter SJ, Leventhal BL, Salt J, Lord C, Corsello C, Hus V, Weeks DE, Volkmar F, Tauber M, Fombonne E, Shih A. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics 2007, 39(3), 319-328.
  • Jayawant S, Parr JR. Outcome following subdural haemorrhages in infancy. Archives of Disease in Childhood 2007, 92(4), 343-347.
  • Blasi F, et al, The IMGSAC. Absence of coding mutations in the X-Linked Absence of coding mutations in the X-Linked genes Neuroligin 3 and Neuroligin 4 in individuals with autism from the IMGSAC collection. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2006, 141(3), 220-221.
  • Parr JR, Pang K, Mollett A, Zaiwalla Z, Selway R, McCormick D, Jayawant S. Epilepsy responds to vagus nerve stimulation in ring chromosome 20 syndrome. Developmental Medicine and Child Neurology 2006, 48(1), 80.
  • Parr JR, Lamb J, Bailey AJ, Monaco AP. Response to paper by Molloy et al.: Linkage on 21q and 7q in autism subset with regression. Molecular Psychiatry 2006, 11(7), 617-619.
  • Lamb JA, Barnby G, Bonora E, Sykes N, Bacchelli E, Blasi F, Maestrini E, Broxholme J, Tzenova J, Weeks D, Bailey AJ, Monaco AP, International Molecular Genetic Study of Autism Consortium. Analysis of the IMGSAC autism susceptibility loci: evidence for sex-limited and parent-of-origin specific effects. Journal of Medical Genetics 2005, 42, 132-137.
  • Parr JR. Autism. Clinical Evidence 2005, 14, 275-284.
  • Parr JR. Autism. Clinical Evidence 2005.
  • Barnby G, Abbott A, Sykes N, Morris A, Weeks DE, Lamb J, Bailey AJ, Monaco AP, International Molecular Genetics Study of Autism Consortium (IMGSAC). Candidate-Gene Screening and Association Analysis at the Autism-Susceptibility Locus on Chromosome 16p: Evidence of Association at GRIN2A and ABAT. Journal of Human Genetics 2005, 76(6), 950-966.
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  • Parr JR, Ward A, Inman S. Current Practice in the Management of ADHD. Child: Care, Health and Development 2003, 29(3), 215-218.
  • Bailey A, Parr J. Implications of the broader phenotype for concepts of autism; General Discussion; Final Discussion. In: Bock, G., Goode, J, ed. Autism: Neural Basis and Treatment Possibilities. Chichester, UK; Hoboken, New Jersey, USA: Wiley-Blackwell, 2003, pp.26-41, 109-111, 281-297.
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  • Beyer KS, Blasi F, Bacchelli E, Klauck SM, Maestrini E, Poustka A, International Molecular Genetic Study of Autism Consortium (IMGSAC). Mutation analysis of the coding sequence of the MECP2 gene in infantile autism. Human Genetics 2002, 111(4-5), 305-309.
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  • Parr J, Baird G, Le Couteur A, Rutter M, Bailey A, IMGSAC. Phenotypic characteristics of autistic regression in an international multiplex sample. In: American Journal of Medical Genetics: 10th World Congress of Psychiatric Genetics. 2002, Brussels, Belgium: John Wiley & Sons, Inc.
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