Institute of Neuroscience

Staff Profile

Dr John-Paul Taylor

Clinical Senior Lecturer/Consultant

Background

Introduction 

Position: Senior Clincial Lecturer, Institute of Neuroscience, and Honorary Consultant in Old Age Psychiatry, Northumberland, Tyne and Wear NHS Trust 

Qualifications and Memberships

MBBS(hons) PhD MRCPscyh

Clinical Roles and Responsibilities

Clinical Lead for specialist Lewy body disease clinic at Northumbria Tyne and Wear NHS Foundation Trust

Academic Clinical Collaboration lead in dementia at Northumbria Tyne and Wear NHS Foundation Trust

Other Roles and Responsibilities

Visiting Professor at "G. d'Annunzio" University of Chieti-Pescara, Italy

ARUK Grants Panel Member

EPAD DPUK lead

Website

www.lewybodylab.org

 

Research

Current Research Interests

  • Neurobiological basis for cognitive and neuropsychiatric symptoms in Lewy body dementias including cognitive fluctuations and visual hallucinations.

  • Application of novel neuroimaging and neurophysiological techniques in dementia (collaborator: Marco Onofrj).

  • Network and multivariate approaches to neuroimaging (collaborators: Sean Colloby, Marcus Kaiser).

  • Clinical characterisation of visual hallucinations (collaborator: Dominic ffytche).

  • Dynamic interaction between vision and cognition (collaborators: Mike Clarke / Daniel Collerton / Urs Mosimann/ Mike Bowen).

  • Use of mice models to investigate cortical dysfunction in Lewy body dementias and develop novel treatments (collaborators: Fiona LeBeau; Laura Bonanni).

  • Prodromal dementia with Lewy bodies clinical cohorts (collaborators: Alan Thomas, Frederic Blanc).

  • Non-invasive stimulation approaches and the application of neurophysiological approaches in dementia (collaborators: Mark Baker, Kianoush Nazarpour).

  • Clinical care models and optimising clinical management pathways for patients with Lewy body dementia.

  • Lead for development of driving and dementia national UK guidelines.

Funding 

  • Newcastle HealthCare Charity £49,851 (2007) "A Novel Study Investigating Visual Cortex Function in Dementia with Lewy Bodies using Transcranial Magnetic Stimulation and MR Imaging".  Acting PI. Application lead: Prof John O’Brien

  • Alzheimer’s Research Trust £29481 (2008) “An fMRI compatible visual perception test battery for demented patients”.   Co-PI

  • Wellcome Starter Grant £22,355 (2009) "A Novel Study Investigating Visual Cortex Function in Dementia with Lewy Bodies using Transcranial Magnetic Stimulation and MR Imaging".  PI

  • Wellcome Intermediate Clinical Fellowship (2010) £572,557 “Investigating attentional function and cognitive fluctuations in Lewy body disease: a functional magnetic imaging and electrophysiology study” also known as CATFieLD study. PI

  • National Institute for Health Research  (NIHR) (2011) £271,208 ”Cataract and Cognitive Impairment in the Elderly” – Clinical Fellowship awarded to Dr Jo JefferisCo-Supervisor

  • FSF - DeNDRoN  (2010) £24,192 for “CATFieLD Study” PI

  • FSF Funding (2011) £25,140 for “CATFieLD Study” PI

  • Alzheimer`s Research UK PhD studentship (2011) £95,670 “Investigating Attentional Function and Cognitive Fluctuations in Lewy Body Disease”. Primary Supervisor

  • National Institute for Health Research  (NIHR) (2012) £1,968,305 “Towards an evidence-based clinical management of visual hallucinations: prevalence, prognosis, impact and pathophysiology” Co-applicant

  • National Institute for Health Research  (NIHR) (2012) £502,429 “The prevalence of visual impairment in people with dementia” Co-applicant

  • Biomedical Research Unit (BRU) (2012) £88,338“ACDC-Lewy study: Acute and Chronic Transcranial Direct Current stimulation treatment in Lewy body dementia patients” PI

  • Biomedical Research Unit (BRU) (2012) PhD studentship and project £190,645.00“Visual hallucinations: an EEG and non-invasive Stimulation study (VEEG-Stim study)” PI & supervisor

  • Northumbria Tyne and Wear NHS Foundation Trust (2013) support grant: £24,338 “CATFieLD, VEEG-Stim and ACDC Lewy” PI

  • Biomedical Research Unit (BRU) (2013) £77,956 “Disruption of brain connectivity in Lewy body dementias: a network analysis approach” PI

  • RCF- (2012) £48,286 “Identifying Early (Prodromal) Dementia with Lewy Bodies (LEWYPRO)” Co-PI

  • NIHR Programme Grants for Applied Research (2013): £1,913,454 DTC-RP-PG-0311-12001 Improving the diagnosis and management of neurodegenerative dementia of Lewy body type in the NHS (DIAMOND-Lewy) Co-PI

  • Alzheimer’s Society (2013) £178,419 “Molecular Mechanisms Underlying Visual Hallucinations in Dementia with Lewy Bodies” Co-PI

  • Biomedical Research Unit (BRU) (2013) £8,480 “New ways of looking at visual hallucinations. A Lewy body dementia study (MRes project)” PI

  • Biomedical Research Centre (BRC) (2013) £10,500 “BRC - Neurodegenerative cortical pathology (MRes project)” PI

  • RCF (2014) £19,044 Northumbria Tyne and Wear NHS Foundation Trust “VEEG-Stim and ACDC Lewy study support” PI

  • RCF (2014) £19,581 Northumbria Tyne and Wear NHS Foundation Trust. Support for NIHR fellowship development. PI

  • Alzheimer’s Society (2014) £262,133.“The influence of cortical neurodegenerative pathology on white matter integrity”Co-PI

  • Biomedical Research Unit (BRU) £51,179. (2014) Deep and frequent phenotyping in dementia (pilot). Local Co-PI

  • Biomedical Research Unit (BRU) £9,091 (2014)  “Functional connectivity of attentional processes in Lewy Body Dementia and Alzheimer's Disease” PI

  • Biomedical Research Unit (BRU) £35,718 (2014)  “Deep brain stimulation” Co-PI

  • Alzheimer’s Society £350,000 (2015) Doctoral Training Centre Grant Co-PI

  • Arthritis UK  £159,608.74 (2015) “Dissecting the tripartite relationship of fatigue, autonomic dysfunction and immune dysregulation” Co-applicant

  • Newcastle Healthcare Charity £35,412 (2015) “New frontiers in electroencephalography and their application to Dementia with Lewy Bodies” PI

  • Sasakawa Foundation £9,000 (2015) Visual hallucinations workshop

  • Lewy body Society £12,894.00 (2015) “Punch Biopsy for Cutaneous a-Synuclein in Dementia with Lewy Bodies (A Pilot and Feasibility Study)” Co-PI

  • Medical Research Council. Proximity to Discovery £2500 (2015) Lewy body dementia industry workshop

  • RCF £18,159 (2016) Support development of academic Lewy Body Disease clinic PI

  • Medical Research Council £980,272.71 (2016) Dementias Platform UK MR-PET Partnership Co-applicant

  • Randerson Foundation PhD Studentship approx £75,000 (2016) Primary applicant

  • Alzheimer’s Research UK £45,112.76 (2016) “Understanding the symptomatic spectrum in dementia with Lewy bodies (DLB): The module dissociation hypothesis of DLB” PI


Teaching

    I teach on the undergraduate biomedical sciences course and postgraduate MRCPsych course. In addition I also teach medical students (Stage III and Stage IV).

    Publications