Dr Kirstie Anderson
Honorary Clinical Senior Lecturer
- Email: firstname.lastname@example.org
- Telephone: 0191 2823833 Opt 6
- Address: Department of Neurology
Royal Victoria Infirmary
Queen Victoria Road
Newcastle upon Tyne
I work within one of the largest and most research active sleep clinics in the UK. Sleep is of the brain, by the brain and for the brain and when we sleep badly for any reason, it has an immediate impact upon our ability to learn and regulate our mood.
SLEEP AND MENTAL HEALTH
I am interested in sleep disturbance in those with mental health problems and in particular bipolar disorder. We know that many patients have severe sleep and circadian rhythm disturbance even when mood is stable and sleep disorders can trigger or exacerbate mood relapse. The ASCRIBE study has been the UKs largest study of sleep and cognition in patients with Bipolar disorder and we hope to understand what part poor sleep plays in cognitive disturbance in those with the condition. I am also working with Dr Stuart Watson to look at the sleep patterns of in-patients within the psychiatry wards in Newcastle to try and measure and then improve sleep disturbance.
SLEEP AND AGEING
Poor sleep is also increasingly recognised as a risk factor for cognitive impairment in both those with who are normally ageing and also those with neurodegenerative disease such as Parkinson's disease or Alzheimers disease. Those who have objectively short sleep were shown to have increased mortality and morbidity when we studied the 85+ cohort, ongoing longitudinal assessments of sleep patterns in the ICICLE cohort (PI Professor D Burn) are providing valuable insights into patterns of sleep that predict cognitive decline.
MEASURING SLEEP OUTSIDE OF THE SLEEP LAB
At present the gold standard for measuring sleep is with an in-patients sleep study (video polysomnography) which is time consuming and relatively invasive for patients who have to come into hospital. Advances in signal processing have led to increasingly sophisticated accelerometer devices that cn more reliably pick up patterns of movement during the day and night that characterise both good and bad sleep. We have validated a novel accelerometer against the gold standard of polysomnography and shown high sensitivity for sleep period detection, importantly the same device can be used as a physical activity monitor. Future work will study sleepwalkers, if we can accurately detect sleepwalking episodes using simple home monitoring devices then we can avoid in-patient studies and record people over days and weeks to both detect symptoms and also measure the benefit of therapies. This work is done in collaboration with Professor Mike Trenell in the MOVElab.
We have also studied the sleep wake patterns of the Biobank cohort to understand the role of lifestyle factors in poor sleep.
Stage 3 MBBS students within the SSC modules, long term conditions and FoCP teaching
PhD Educational supervisor
Educational supervisor for core medical trainees within Newcastle upon Tyne Hospitals
Trainer on the psychology PWP diploma course
- Payne B, Chadwick TJ, Blamire A, Anderson KN, Parikh J, Qian J, Hynes AM, Wilkinson J, Price DA. Does efavirenz replacement improve neurological function in treated HIV infection?. HIV Medicine 2017, Epub ahead of print.
- O'Dowd S, Galna B, Morris R, Lawson RA, McDonald C, Yarnall AJ, Burn DJ, Rochester L, Anderson KN. Poor Sleep Quality and Progression of Gait Impairment in an Incident Parkinson’s Disease Cohort. Journal of Parkinson's Disease 2017, epub ahead of print.
- Raper J, Jenabi F, Lim A, Whittaker R, Anderson K, Basu A. Progressive weakness, ptosis and pseudomyopathic face as the presenting features in a patient with narcolepsy. In: British Paediatric Neurology Association Annual Meeting. 2017, Cambridge: Wiley-Blackwell Publishing Ltd.
- Bradley AJ, Webb-Mitchell R, Hazu A, Slater N, Middleton B, Gallagher P, McAllister-Williams H, Anderson KN. Sleep and circadian rhythm disturbance in bipolar disorder. Psychological Medicine 2017, Epub ahead of print.
- Payne B, Chadwick T, Blamire A, Qian J, Hynes AM, Wilkinson J, Price DA, Anderson K. Neurocognitive and neurometabolic effects of switch from efavirenz to ritonavir-boosted lopinavir. In: 22nd Annual Conference of the British HIV Association (BHIVA). 2016, Manchester: Wiley-Blackwell Publishing Ltd.
- van Hees VT, Sabia S, Anderson KN, Denton SJ, Oliver J, Catt M, Abell JG, Kivimaki M, Trenell MI, Singh-Manoux A. A Novel, Open Access Method to Assess Sleep Duration Using a Wrist-Worn Accelerometer. PLOS One 2015, 10(11), e0142533.
- Anderson KN. An update in sleep neurology: the latest bedtime stories. Journal of Neurology 2015, 262(2), 487-491.
- Elder GJ, Colloby SJ, Lett DJ, O'Brien JT, Anderson KN, Burn DJ, McKeith IG, Taylor JP. Depressive symptoms are associated with daytime sleepiness and subjective sleep quality in dementia with Lewy bodies. International Journal of Geriatric Psychiatry 2015, (ePub ahead of Print).
- Anderson KN, Catt M, Collerton J, Davies K, von Zglinicki T, Kirkwood TBL, Jagger C. Assessment of sleep and circadian rhythm disorders in the very old: the Newcastle 85+ Cohort Study. Age and Ageing 2014, 43(1), 57-63.
- Moriarty AS, Bradley AJ, Anderson KN, Watson S, Gallagher P, McAllister-Williams RH. Cortisol awakening response and spatial working memory in man: a U-shaped relationship. Human Psychopharmacology: Clinical & Experimental 2014, 29(3), 295-298.
- Prudon B, Duncan GW, Khoo TK, Yarnall AJ, Burn DJ, Anderson KN. Primary sleep disorder prevalence in patients with newly diagnosed Parkinson's Disease. Movement Disorders 2014, 29(2), 259-262.
- Anderson K, Di Maria C, Allen J. Novel assessment of microvascular changes in idiopathic restless legs syndrome (Willis-Ekbom disease). Journal of Sleep Research 2013, 22(3), 315-321.
- Blakely EL, Yarham JW, Alston CL, Craig K, Poulton J, Brierley C, Park SM, Dean A, Xuereb JH, Anderson KN, Compston A, Allen C, Sharif S, Enevoldson P, Wilson M, Hammans SR, Turnbull DM, McFarland R, Taylor RW. Pathogenic Mitochondrial tRNA Point Mutations: Nine Novel Mutations Affirm Their Importance as a Cause of Mitochondrial Disease. Human Mutation 2013, 34(9), 1260-1268.
- Prudon B, Duncan GW, Yarnall AJ, Burn DJ, Anderson K. Primary sleep disorder prevalence in patients with newly diagnosed Parkinson's disease. In: American Thoracic Society International Conference. 2013, Philadelphia: American Thoracic Society.
- Anderson KN, Kelly TP, Griffiths TD. Primary sleep disorders can cause long-term sleep disturbance in patients with autoimmune mediated limbic encephalitis. Clinical Neurology and Neurosurgery 2013, 115(7), 1079-1082.
- Anderson K, Jones DEJ, Wilton K, Newton JL. Restless leg syndrome is a treatable cause of sleep disturbance and fatigue in primary biliary cirrhosis. Liver International 2013, 33(2), 239-243.
- Dimaria C, Allen J, Anderson KN. Novel thermovascular changes in restless legs syndrome using thermal imaging and laser Doppler flowmetry. In: 21st Congress of the European Sleep Research Society. 2012, Paris, France: Wiley-Blackwell Publishing Ltd.
- Anderson KN, Waton T, Armstrong D, Watkinson HM, Mackin P. Sleep disordered breathing in community psychiatric patients. European Journal of Psychiatry 2012, 26(2), 86-95.
- Burn DJ, Anderson K. To sleep, perchance to dement: RBD and cognitive decline in Parkinson's disease. Movement Disorders 2012, 27(6), 671-673.
- Lovell BL, Bullock RE, Anderson KN. An unusual presentation of congenital central hypoventilation syndrome (Ondine's Curse). Emergency Medicine Journal 2010, 27(3), 237-238.
- Anderson KN, Vincent A, Smith IE, Shneerson JM. Cerebrospinal fluid hypocretin levels are normal in idiopathic REM sleep behaviour disorder. European Journal of Neurology 2010, 17(8), 1105-1107.
- Jaiser SR, Cassidy A, Guadagno JV, Schaefer AM, Anderson K, Goonetilleke A. Denture Cream as a Cause of Copper Deficiency and Neurological Disease. In: Journal of Neurology, Neurosurgery and Psychiatry: ABN Joint Annual Meeting/Spanish Society of Neurology. 2009, Liverpool, UK: BMJ Group.
- Anderson KN, Hatfield C, Kipps C, Hastings M, Hodges JR. Disrupted sleep and circadian patterns in frontotemporal dementia. European Journal of Neurology 2009, 16(3), 317-323.
- Anderson KN, Shneerson JM. Drug Treatment of REM Sleep Behavior Disorder: the Use of Drug Therapies Other Than Clonazepam. Journal of Clinical Sleep Medicine 2009, 5(3), 235-239.
- Dayal A, Anderson KN. The neurological sleep clinic: how to develop a service for those who do not snore. In: Association of British Neurologists Annual Meeting 2009. 2009, Liverpool, UK: Journal of Neurology, Neurosurgery & Psychiatry: BMJ Publishing Group.
- Anderson KN, Shneerson JM. Novel therapies in REM sleep behaviour disorder. Journal of Sleep Research 2008, 17, 206-206.
- Anderson KN, Pilsworth S, Jamieson S, Ray J, Shneerson JM, Lennox GG. Sleep disturbance in adults with Angelman syndrome. Sleep and Biological Rhythms 2008, 6(2), 95-101.
- Blakely EL, Goodall JA, Anderson KN, Betts JL, Dean AF, Allen CMC, Compston A, Turnbull DM, Taylor RW. A novel mitochondrial DNA tRNA gene mutation in a family with mitochondrial encephalopathy. In: Journal of Inherited Metabolic Disease. 2006, Springer Netherlands.