Institute of Neuroscience

Staff Profile

Dr Nichola Lax

Research Associate

Research

I'm interested in understanding the impact of mitochondrial DNA mutations on the brain and how they contribute to development of neurological deficits, such as ataxia and epilepsy, in patients with mitochondrial disease. One of my current studies is focussed on elucidating the pathological mechanisms responsible for grey matter cortical lesions commonly reported in patients. I want to understand the symptoms associated with these features, such as epilepsy and stroke-like episodes, and how they impact on disease progression. The majority of my work uses human brain tissue to characterise and investigate pathological changes using a combination of molecular genetics, enzyme histochemistry and immunohistochemistry. To help me with my research I collaborate with a diverse range of people from different specialities including, neurologists, electrophysiologists, neuroradiologists, neuropathologists, staff at the NBTR and other members of within our group. In the future I hope to be able to investigate the observed neuropathological changes using appropriate animal models.

Publications