Newcastle University

Research Interests

Multiple Sclerosis

Other Expertise

Neurology

Current Work

Studying mechanisms of axonal loss in MS

Research Roles

Senior Lecturer and supervisor of The MS Group

Postgraduate Supervision

Supervising two post docs

Funding

DH Clinician Scientist Award

Industrial Relevance

Potential for the development of Neuroprotective agents in MS

Undergraduate Teaching

Clinical teaching to MBBS course

Postgraduate Teaching

MRes course

• Hogan V, White K, Edgar J, McGill A, Karim S, McLaughlin M, Griffiths I, Turnbull D, Nichols P. Increase in mitochondrial density within axons and supporting cells in response to demyelination in the Plp1 mouse model. Journal Neuroscience Research 2009, 87(2), 452-459.
• White KE, Davies VJ, Hogan VE, Piechota MJ, Nichols PP, Turnbull DM, Votruba M. OPA1 Deficiency Associated with Increased Autophagy in Retinal Ganglion Cells in a Murine Model of Dominant Optic Atrophy. Investigative Ophthalmology & Visual Science 2009, 50(6), 2567-2571.
• Davies VJ, Powell KA, White KE, Yip W, Hogan V, Hollins AJ, Davies JR, Piechota M, Brownstein DG, Moat SJ, Nichols PP, Wride MA, Boulton ME, Votruba M. A missense mutation in the murine Opa3 gene models human Costeff syndrome. Brain 2008, 131(2), 368-380.
• Samarasekera SR, Vincent A, Welch JL, Jackson M, Nichols P, Griffiths TD. Course and outcome of acute limbic encephalitis with negative voltage-gated potassium channel antibodies. Journal of Neurology, Neurosurgery and Psychiatry 2007, 78(4), 391-394.
• Davies VJ, Hollins AJ, Piechota MJ, Yip W, Davies JR, White KE, Nichols PP, Boulton ME, Votruba M. Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function. Human Molecular Genetics 2007, 16(11), 1307-1318.
• Andrews H, White K, Thomson C, Edgar J, Bates D, Griffiths I, Turnbull D, Nichols P. Increased axonal mitochondrial activity as an adaptation to myelin deficiency in the Shiverer mouse. Journal of Neuroscience Research 2006, 83(8), 1533-1539.
• Barron MJ, Griffiths P, Turnbull DM, Bates D, Nichols P. The distributions of mitochondria and sodium channels reflect the specific energy requirements and conduction properties of the human optic nerve head. British Journal of Ophthalmology 2004, 88(2), 286-290.
• Mulleague L, Bonner SM, Samuel A, Nichols P, Khan M, Shaw S, Gruning T. Wound botulism in drug addicts in the United Kingdom. Anaesthesia 2001, 56(2), 120-123.
• Nichols P, Croxen R, Vincent A, Rutter R, Hutchinson M, Newsom-Davis J, Beeson D. Mutation of the Acetylcholine Receptor ɛ-Subunit Promoter in Congenital Myasthenic Syndrome. Annals of Neurology 1999, 45(4), 439-443.
• Nichols P. and D. Beeson. Control of Gene Expression of Human Muscle Acetylcholine Receptor. Ann. N. Y. Acad. Sci 1998, 841, 111-114.
• Nichols P., J. Owen, H. Ellis, J. Farndon, P. Kelly, M. Ward. Parathyroidectomy in chronic renal failure. A nine year follow up study. Quart. J. Med 1990, 283, 1175-1193.