Professor Simon Thomas
Prof of Clin Pharmacology & Therapeutics

  • Email: simon.thomas@ncl.ac.uk
  • Telephone: +44 (0) 191 208 8094
  • Fax: +44 (0) 191 282 0288
  • Address: Wolfson Unit of Clinical Pharmacology
    Institute of Cellular Medicine
    Medical School
    Newcastle University
    NE2 4HH

Roles and Responsibilities

Professor of Clinical Pharmacology and Therapeutiics, Newcastle University

Consultant Physician, Newcastle Hospitals NHS Foundation Trust 

Qualifications

MBBS, MRCP(UK), MD (London University), FRCP, FRCP (Edin)

Previous Positions

Senior Registrar in Clinical Pharmacology, Freeman Hospital, Newcastle
Lecturer in Clinical Pharmacology, UMDS (St Thomas' Campus), London University

Memberships

British Pharmacological Society
British Toxicology Society
British Hypertension Society
European Association of Poisons Centres and Clinical Toxicologists

Research Interests

Adverse drug reactions
Pharmacovigilance
Pharmacoepidemiology
Drug-induced arrythmia
Poisoning and Clinical Toxicology
Hypertension

Other Expertise

Ethics and research governance

Current Work

Current research projects include

(a)risk factors for hepatotoxicity following paracetamol poisoning
(b) Differential toxicity of tricyclic antidepressants
(c) Cardiotoxicity of antipsychotic drugs
(d) Fetal toxicity associated with maternal exposure to drugs and chemicals
(e) Optimum out of hospital management of civilians exposed to chemical weapons
(f) Long term health effects of chemical weapons exposure
(g) Clinical trials in hypertension and cardiovascular risk reduction

Research Roles

PI
Research student supervisor

Postgraduate Supervision

Supervisor of students for Dip Ther, MRes, MD, MPhil and PhD

Esteem Indicators

Keynote lectures:
British Toxicology Society (1998)
In Vitro Toxicology Society (1999)
Royal College of Physicians of London (1999)
Royal College of Physicians of Edinburgh (2005)
European Association of Poisons Centres and Clinical Toxicologists (2000, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010)
International Association for Accident and Emergency Medicine (2002)
SCIPharm (2004)
Association of Clinical Biochemists (2003, 2007)
American Academy of Clinical Toxicology (2005, 2006)
American Board of Applied Toxicology (2007)

Northern and Yorkshire Multicentre Research Ethics Committee (Chairman), 2000-2006
Committee on Safety of Medicines Subcommittee on Pharmacovigilance (Member)1998-2006
Advisory Council on the Misuse of Drugs, Technical Subcommittee (Member) 1998-
National Poisons Information Service Board and Clinical Standards Group, (Chair, 2000-2001 and 2005-)
British Pharmacological Society, Clinical Pharmacology Committee (Member), 2003-2006
Multicentre Research Ethics Committees Chairman’s Group (Member)
European Association of Poisons Centres and Clinical Toxicologists - Scientific Committee (Vice Chair, 2004-5,Chair 2005-8, Board (2006-), President (2010-12)
Commission on Human Medicines, Pharmacovigilance Expert Advisory Group 2006-9
Commission on Human Medicines, 2009-
National Institute for Health and Clinical Excellence (NICE) Appraisal Committee A (2006-9)

Editorial Boards:
British Journal of Clinical Pharmacology
European Journal of Clinical Pharmacology
Drug Safety
Clinical Toxicology
Toxicology Reviews (2005-2007)

Funding

Medical Research Council. £29,890 (Small grant) to study QT interval abnormalities, sudden death and drug therapy in psychiatric patients (1995, with Prof IN Ferrier and Dr J Riley)
NHS Executive Research and Development Programme. £53,307 to perform a cost-utility study of beta-interferon for multiple sclerosis (1996, with Dr D Parkin, Dr A Jacoby and Dr D Bates)
Drug Safety Research Unit. £71,000 to take part in a case control study examining the risks of myocardial infarction with 2nd and 3rd generation oral contraceptives (1996).
Imperial College, London. £1,000,000. Newcastle Centre of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT, 1998).
Department of Health. Total £354,000, Newcastle funding £50,251. Sudden death in Psychiatric in-patients. With Prof Ferrier (Academic Psychiatry) and University of Manchester.
Home Office. Chronic health effects from exposure to chemical agents. £1,070,314 (With Prof Blain)
Home Office. Optimal deployment of medical responders in the warm / hot zone. £266,896 (With Prof Blain)
Egyptian Government. Relative toxicity of tricyclic and other antidepressants. £11,556
Boeringer Ingelheim Ltd. RELY Study. £570,000
Wellcome trust. Training fellowships in translational medicine and therapeutics. £2.9M. With Prof D Jones, Prof GA Ford, Prof P Chinnery
FP7-HEALTH-2009- single-stage (2009-12). Arrhythmogenic potential of drugs (ARITMO). €160,000
EU Innovative Medicines Initiative. Pharmacoepidemiological Research on Outcomes of Therapeutics by a European ConsorTium (PROTECT-EU). €238,890
EU Innovative Medicines Initiative. Pharmaceutical Medicine Training Programmes (PharmaTrain). €18,333
National Institute for Health Research. Influenza A/H1N1v in pregnancy. £108,899

Industrial Relevance

None

Patents

None