Dr William Sedley
Academic Clinical Lecturer in Neurology
- Email: email@example.com
- Address: Auditory Group
Institute of Neuroscience
Henry Wellcome Building
Newcastle upon Tyne
BackgroundMy background is in medicine, and I am currently a specialist registrar in Neurology, based at the Royal Victoria Infirmary in Newcastle where I spend half my working week. I also hold an NIHR-funded Academic Clinical Lecturer post, which allows me to spend the other half of my week conducting research into neuroscience and neurological disorders.
My research interests are in the study of perception, particularly hearing, with a focus on perceptual disorders such as tinnitus and musical hallucinations. However, my clinical practice predominantly relates to disorders typically referred to and managed by neurologists. More recently I am beginning to start running experiments on patients with functional neurological disorders.
I have been interested in the neuroscience of tinnitus since 2008, when I began researching the area. My work focuses on processes related to, and responsible for, tinnitus measured at the level of auditory cortex (the higher hearing centre in the brain) in human volunteers. My studies so far have measured electrical brain activity, as well as brain structure and chemistry.
My previous work has been based both in Newcastle and in London, while my current and planned work is taking place in Newcastle only. Currently planned work aims to better understand tinnitus brain mechanisms using brainwave responses measured by EEG, and also to begin to develop a new treatment for tinnitus based on sound therapy and conduct initial testing.
I am happy to be contacted by patients with tinnitus, though I note that I do not have any particular expertise with the clinical management of tinnitus, which can be better delivered by ENT or Audiology services. I will advertise for research volunteers once experiments are at a suitable stage, but in the meantime I keep a list of interested volunteers who contact me, who I contact in due course if they might be suitable for an upcoming experiment. However, I am sometimes unable to respond quickly.
All of my published papers from previous work are freely downloadable (see 'Publications' section, and just enter the name of any one into a web search engine to find the download page), and of course these could only take place thanks to the generosity and dedication of my volunteers.
Normal sensory (auditory) processing
I have been working on brain mechanisms of normal sound processing since 2007, when I started looking at pitch processing. I have continued this line of work due to interest in the subject in its own right, and also in order to better be able to understand the relevance of these brain processes in the context of abnormal perception such as in tinnitus. Recently, I have worked on the Predictive Coding model of brain function, and how this framework specifically relates to the neural signatures of sound processing we have previously observed. These results, and this framework, have formed much of the basis of a new model of tinnitus that is currently in press, which resolves a number of previously insoluble paradoxes.
Other perceptual disorders
Through collaboration, I have been involved in studies into the brain basis for uncommon disorders of sound processing, including musical hallucinations and misophonia, and helped to develop brain models of these disorders.
Functional neurological disorders
These are one of the most commonly encountered conditions in neurology, and refer to dysfunction of the nervous system (such as weakness or loss of sensation) in the absence of any physical damage to the nerves. They can occur due to triggering events such as injuries, due to psychological factors, life events, or often for no identifiable reason. Presently the brain basis of these conditions is not well understood, and there are no diagnostic tests, with diagnosis relying on clinical examination and tests to exclude physical damage to the nervous system. I am in the process of setting up a study into the brain mechanism of these conditions, which may even lead on to development of a diagnostic test.
TeachingI do not conduct regular formal teaching as part of my official post, but have performed teaching of various sorts in various capacities.
- Sedley W, Parikh J, Edden R, Tait V, Blamire A, Griffiths T. Human auditory cortex neurochemistry reflects the presence and severity of tinnitus. Journal of Neuroscience 2015, 35(44), 14822-14828.
- Sedley W, Gander PE, Kumar S, Oya H, Kovach CK, Nourski KV, Kawasaki H, Howard III MA, Griffiths TD. Intracranial Mapping of a Cortical Tinnitus System using Residual Inhibition. Current Biology 2015, 25(9), 1208-1214.
- Helbling S, Teki S, Callaghan MF, Sedley W, Mohammadi S, Griffiths TD, Weiskopf N, Barnes GR. Structure predicts function: Combining non-invasive electrophysiology with in-vivo histology. NeuroImage 2015, 108, 377-385.
- Kumar S, Sedley W, Barnes GR, Teki S, Firston KJ, Griffiths TD. A brain basis for musical hallucinations. Cortex 2014, 52, 86-97.
- Sedley W, Cunningham MO. Do cortical gamma oscillations promote or suppress perception? An under-asked question with an over-assumed answer. Frontiers in Human Neuroscience 2013, 7, 595.
- Sedley W, Teki S, Kumar S, Overath T, Barnes GR, Griffiths TD. Gamma band pitch responses in human auditory cortex measured with magnetoencephalography. NeuroImage 2012, 59(2), 1904-1911.
- Sedley W, Teki S, Kumar S, Barnes GR, Bamiou DE, Griffiths TD. Single-subject oscillatory gamma responses in tinnitus. Brain 2012, 135(10), 3089-3100.
- Kumar S, Sedley W, Nourski KV, Kawasaki H, Oya H, Patterson RD, Howard MA, Friston KJ, Griffiths TD. Predictive Coding and Pitch Processing in the Auditory Cortex. Journal of Cognitive Neuroscience 2011, 23(10), 3084-3094.
- Cope TE, Sedley W, Griffiths TD. Timing and the auditory brain. Advances in Clinical Neuroscience and Rehabilitation 2011, 10(6), 10-13.
- Griffiths TD, Kumar S, Sedley W, Nourski KV, Kawasaki H, Oya H, Patterson RD, Brugge JF, Howard MA. Direct Recordings of Pitch Responses from Human Auditory Cortex. Current Biology 2010, 20(12), 1128-1132.