Past Research Projects
- A Double-Blind, Placebo-Controlled, Randomized, Parallel group study evaluating the safety, Tolerability and efficacy of two different oral doses of NP031112, a GSK-3 inhibitor, versus placebo in the treatment of patients with mild - to moderate Progress
Project Leader(s): Professor David Burn - A novel fMRI compatible visual perception test battery for demented patients
Project Leader(s): Dr Urse Mossman/Professor John O'Brien - A phase 2/3 randomised double-blind placebo-controlled study to evaluate the safety and efficacy of Davunetide for the treatment of Progressive Supranuclear Palsy.
Project Leader(s): Professor David Burn - A Phase 2a, Double Blind, Randomized, Placebo-controlled, 28 day, Two-arm, Parallel Group Study of A0001 in Patients with the A3243G Mitochondrial DNA Point Mutation and Evidence of Impaired Mitochondrial Function
Project Leader(s): Professor Patrick Chinnery - A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Efficacy and Safety Trial of Bapineuzumab (AAB-001) in Subjects with Mild to Moderate Alzheimer Disease Who Are Apolipoprotein E4 Carriers
Project Leader(s): Dr Bob Barber - A phase 4 prospective exploratory muscle biopsy, biomarker and imaging assessment study in patients with late-onset Pompe disease treated with alglucosidase alfa
Project Leader(s): P.I. Professor Volker Straub - A randomised, double-blind, placebo-controlled, phase 2 study evaluating the efficacy of ABT-888 in combination with Temozolomide vs Temozolomide alone in subjects with metastatic melanoma
Project Leader(s): Professor Ruth Plummer - Ageing, Cardiac Energy Metabolism and Diastolic Function
Project Leader(s): Dr Guy MacGowan - An abdominal imaging, substrate analysis and laboratory sample collection sub-study for participants who have enrolled in LAL-2-NH01
Project Leader(s): Dr Patrick Deegan (Cambridge University Hospitals) - Apixaban versus ASA to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment: A randomised double blind trial
Project Leader(s): Professor Simon Thomas - Application of novel techniques of high field magnetic resonance for the non-invasive investigation of diabetic kidney disease.
Project Leader(s): Professor S M Marshall - Bipolar Disorder Imaging
Project Leader(s): Professor Nicol Ferrier - Brand representation in autobiographical memory: a neurocognitive approach
Project Leader(s): Dr Amanda Broderick/Dr Rachel Mitchell - Cardiac tagging/morphology in CFS/ME
Project Leader(s): Professor Julia Newton - Cerebral Blood Flow Following TNF Antagonism in Rheumatoid Arthritis
Project Leader(s): Professor John Isaacs - Comparative Neuroimaging of Auditory and Cross-sensory Perception
Project Leader(s): Dr. Christopher Petkov and Dr. Quoc Vuong - Correlation between phonology/reading and complex acoustic processing relevant to speech analysis
Project Leader(s): Professor Tim Griffiths/Dr Manon Grube - Defining the prevalence of autonomic dysfunction and its consequences in ME/CFS - a clinical cohort study.
Project Leader(s): Professor Julia Newton - Development of high field magnetic resonance techniques for the non-invasive investigation of diabetic kidney disease
Project Leader(s): Professor Sally Marshall - Effect of aerobic exercise on cardiac function and movement in people with mitochondrial disease- Project Summary
Project Leader(s): Dr M I Trenell, Professor Doug Turnbull, Dr Grainne Gorman and Jane Newman - Effect of change in pancreas and liver fat content upon beta cell function and hepatic insulin action during weight loss in type 2 diabetes
Project Leader(s): Professor Roy Taylor - Effect of exercise on metabolism and liver lipid in people with non-alcoholic fatty liver disease (NAFLD)
Project Leader(s): Dr Mike Trenell, Professor Roy Taylor, Dr Kieren Hollingsworth and Professor Chris Day - Effects of maltodextrin and galactose with or without added protein on liver and muscle glycogen synthesis during short-term recovery and on post-recovery cycling performance
Project Leader(s): Dr Mike Trenell - Exercise in patients with single mitochondrial DNA deletions
Project Leader(s): Professor Doug Turnbull - fMRI Study of Category-Based Inductive Reasoning
Project Leader(s): Dr Amy Crisp - Growth and metabolic outcome in children born preterm
Project Leader(s): Dr Mike Trenell, Dr Nick Embleton and Dr Rob Tinnion - Intensive Blood Pressure lowering in older people: A study to determine feasibility, tolerability and effects on brain structure and perfusion
Project Leader(s): Professor Gary Ford - Intention maps in parietal cortex
Project Leader(s): PI: Dr Jason Connolly - International Carotid Stenting Study (ICSS)
Project Leader(s): Paul Dorman - Investigating the effects of amphetamine on neuropsychological and neuroimaging parameters in the normal human brain and the interaction with Lithium
Project Leader(s): Dr David Cousins - Investigating the role of raised blood ammonia in patients with hepatic encephalopathy
Project Leader(s): Dr Chris Record - Investigating visual cortex function in dementia with Lewy bodies using transcranial magnetic stimulation and MR imaging
Project Leader(s): Professor John O’Brien and Dr John-Paul Taylor - Is the treatment of HIV causing irreversible mitochondrial damage?
Project Leader(s): Professor Patrick Chinnery - Lipid metabolism in normal pregnancy - A magnetic resonance pilot study
Project Leader(s): Professor Roy Taylor/Dr Ken Hodson/Dr Stephen Robson - Magnetic Resonance Imaging (MRI) & Magnetic Resonance Spectroscopy (MRS) study in patients with Fukutin Related Protein (FKRP) Limb girdle muscular dystrophy 2I (LGMD2I)
Project Leader(s): Professor Volker Straub/Dr Tracey Willis - Measuring brain iron in patients with neuroferritinopathy: pilot stuidy defining a surrogate marker amenable to therapeutic modulation
Project Leader(s): Professor Patrick Chinnery - MRI studies of chronic progressive external ophthalmoplegia
Project Leader(s): Mr Philip Griffiths - Orthostatic Hypertension, MR Changes and Depression
Dr A Thomas - Physiological effect of age on metabolism (muscle, cardiac and abdominal) probed by MR methods, stratified for age and habitual physical activity
Project Leader(s): Dr Mike Trenell - Spatial coordinate frames in posterior parietal cortex.
Project Leader(s): Dr Jason Connolly - Spatial Memory & fMRI
Project Leader(s): Dr Jonna Nilsson and Professor Nicol Ferrier - Studies assessing the role of auditory and cross-sensory perception with psychophysics and MRI
Project Leader(s): Dr C. Petkov - The dynamics of postprandial lipid and carbohydrate interaction in liver and muscle of normal and diabetic subjects
Project Leader(s): Professor Roy Taylor - The effect of a fitness and mobility exercise programme on glucose control and blood flow in the brain in older adults with chronic stroke.
Project Leader(s): Dr M I Trenell and Sarah Moore - The mechanisms responsible for fatigue and impaired health status of subjects with sub clinical hypothyroidism; study before and after L-Thyroxine therapy (also investigating the biological basis of fatigue in chronic disease)
Project Leader(s): Dr Jolanta Weaver and Dr Madathil - The Nature of Brain Changes in the Progression of Bipolar Disorder
Project Leader(s): Dr Pablo Najt - Validation of the Arterial Spin Labelling Technique for the Assessment of Renal Perfusion
Project Leader(s): Professor Sally Marshall
