Effect of change in pancreas and liver fat content upon beta cell function and hepatic insulin action during weight loss in type 2 diabetes

Project Leader(s): Professor Roy Taylor
Sponsors: Diabetes UK

Recent studies have shown that type 2 diabetes can be cured after weight loss surgery in obese people. This appears to be a result of decreasing the effect of excess fat accumulated  in the liver and in the pancreas itself. The effects of the surgery can be reproduced by intensive dieting, indicating effect by sudden fall in food intake and mobilisation of the excess fat. These conclusions have been drawn from a number of studies and it is now important to perform a prospective dietary study to test the findings and define how quickly the liver and the pancreas return to normal. The study has the potential to simplify understanding of, and lead to definitive treatment for, type 2 diabetes.

Staff Profile: Professor Roy Taylor

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