Project Leader(s): Dr John Sayer
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited kidney disease leading to cystic enlargement of the kidneys and progressive renal failure. The "PKD 291 OVERTURE STUDY" is an industry sponsored study to identify and characterize factors which predict rapid progression toward, or higher frequency of, clinically relevant morbidities in ADPKD. The study will investigate a correlation between the rate of kidney enlargement and the decline of renal function in ADPKD patients and establish the utility of renal volume measurements as a prognostic marker of disease progression. Each subject is expected to be followed with 6 monthly MRI scans of the kidneys to determine criteria for ADPKD progression. This study will include males and females aged 12-70 years with APDKD.