Project:

AptaMEMS-ID: Detecting infectious organisms: a concerted approach using genomics, molecular engineering and nano-enabled bio-MEMS technologies

From May 2009 to April 2012
Project Leader(s): Prof Calum McNeil
Staff: Prof Colin Harwood, Prof Anil Wipat, Dr Phil Manning, Dr Barry Gallacher, Dr John Hedley, Dr James Henderson, Dr Neil Keegan
Contact: John.Hedley@ncl.ac.uk
Sponsors: EPSRC
Partners: NHS Foundation Trust

The AptaMEMS-ID project brings together several teams with complementary expertise to create nano-enabled sensor systems for the detection of infectious organisms.

The functional integration of man-made devices and biological systems represents one of the grand challenges of science and technology and it is now widely accepted that a combination of nanotechnology and engineering that harnesses the full potential of genomic information through real-time predictive, preventive, point-of-care healthcare provision will lead to the next technological revolution. This project, which lies at the heart of the confluence of nano-, bio-, micro- and genomic technologies, proposes to use nano-enabled biological sensor technology for the development of a point-of-care system for the rapid detection of infectious organisms. The proposal is based around the clinical and societal need for rapid detection of specific nosocomal infections for screening, diagnostic and epidemiological uses and involves a combination of technologies encompassing; comparative genomics, novel bioinformatics, confirmatory proteomics, molecular engineered peptide aptamer ligands and microelectromechanical (MEMS) sensor technologies which exploit effectively at the nano-scale: design, manufacture, functionalization and molecular patterning.

Staff

Dr Barry Gallacher
Reader in Engineering Dynamics

Dr John Hedley
Senior Lecturer