Newcastle University

Roles and Responsibilities

Deputy Programme Director MBBS

Qualifications

FRCP
PhD (University of Birmingham)
MB.BS (University of London)
B.Sc (University of Birmingham)

Previous Positions

First Assistant, Department of Medicine, University of Newcastle 1994-1998
MRC Travelling Fellow and Howard Hughes Fellow, Havard University 1992-1994

Memberships

Endocrine Society
Society for Endocrinology

Research Interests

Stem cell biology
Pancreas development
Developmental Endocrinology
Gene regulation

Other Expertise

Endocrine responses in critical illness
Thyroid hormone action
Body fluid homeostasis

Future Research

Stem cells as cell replacement therapy in endocrine disease, with particular reference to Diabetes

Funding

Juvenile Diabetes Foundation project grant (in collabloration with Drs Hanley and Wilson)
University Hospital Special Trustees Project grant

Undergraduate Teaching

Deputy Programe Director MBBS
Course Director Hospital-Based Practice module MBBS
Course Director Preparing for Practice module MBBS

• Hannon MJ, Orr C, Moran C, Behan LA, Agha A, Ball SG, Thompson CJ. Anterior Hypopituitarism is Rare and Autoimmune Disease is Common in Adults with Idiopathic Central Diabetes Insipidus. Clinical Endocrinology 2012, (epub ahead of print).
• Ball S. Diabetes Insipidus [Android and iPhone App 'Endocrinology and Endocrine Emergencies']. [program]. South Dartmouth, MA, USA: Endocrine Education Inc, 2011.
• Munir A, Ball S. Hyponatraemia [Android and iPhone App 'Endocrinology and Endocrine Emergiencies']. [program]. South Dartmouth, MA, USA: Endocrine Education Inc, 2011.
• Piper K, Ball S, Turnpenny L, Brickwood S, Wilson D, Hanley N. Beta-cell differentiation during human development does not rely on nestin-positive precursors: Implications for stem cell-derived replacement therapy. Diabetologia 2002, 45(7), 1045-1047.
• Woods D, Hooper T, Mellor A, Hodkinson P, Wakeford R, Peaston B, Ball S, Green N. Brain natriuretic peptide and acute hypobaric hypoxia in humans. Journal of Physiological Sciences 2011, 61(3), 217-220.
• Cotterill S, Horner P, Teasdale D, Ellis J, Thomason JM, Vernazza C, Bradley PM, Peterson J, Skelly G, Ball S. Effective embedding and integration of ePortfolios in medical and dental curricula. International Journal of Clinical Skills 2011, 5, 18-23.
• Sinha A, Ball S, Jenkins A, Hale J, Cheetham T. Objective assessment of thirst recovery in patients with adipsic diabetes insipidus. Pituitary 2011, 14(4), 307-311.
• Druce MR, Walker D, Maher KT, Dodzo K, Perry L, Ball S, Peaston R, Chew SL, Drake WM, Akker SA, Grossman AB. The Effect of Exogenous Glucocorticoids on Plasma Catecholamines and Metanephrines in Patients Without Phaeochromocytomas. Hormone and Metabolic Research 2011, 43(4), 292-295.
• Ball SG. The neurohypophysis. In: Wass, J.A.H., Stewart, P.M, ed. Oxford Textbook of Endocrinology and Diabetes. Oxford: Oxford University Press, 2011, pp.82-98.
• Ball SG, Baylis PH. Chapter 2: Normal and abnormal physiology of the hypothalamus and posterior pituitary. MDText.com, Inc., 2009. Available at: http://www.endotext.org/neuroendo/neuroendo2/neuroendo2.htm.
• Ball S. Diabetes Insipidus. Medicine 2009,37 8 414-415.
• Ball SG. Vasopressin and disorders of water balance: The physiology and pathophysiology of vasopressin. Annals of Clinical Biochemistry 2007. , 44(5), 417-431.
• Ball SG, Douglas F, Lennard TWJ. Familial endocrine disease: genetics, clinical presentation and management. In:Lennard TWJ, ed. Endocrine Surgery.Philadephia:Elsevier Saunders,2006, pp. 105-128.
• Dharmaraj P, Ball S, Johnstone H, Bailey S, Clifford SC, Hale J, Cheetham T. Hypercalcaemia in relapsed medulloblastoma 8 years post-diagnosis; evidence to support PTHrP production by medulloblastoma cells. Hormone Research 2006, 66(6), 268-272.
• Ball SG, Baylis PH. Vasopressin, diabetes insipidus, and Syndrome of inappropriate antidiuresis. In:Degroot, LJ; Jameson, JL, ed. Endocrinology.Philadelphia:Elsevier Saunders,2006, pp. 537-556.
• Silveira L, Tanriverdi F, MacColl G, Ball SG, Bouloux P-MG, de Marco LA, Quinton R. A novel nonsense mutation of the KAL1 gene in a family with Kallmann. In: 12th International Congress of Endocrinology. 2004, Lisbon.
• Piper K, Brickwood S, Turnpenny LW, Cameron IT, Ball SG, Wilson DI, Hanley NA. Beta cell differentiation during early human pancreas development. Journal of Endocrinology 2004,181 1 11-23.
• Abouglila K, Miller M, Ball SG. Osteomalacia precipitated by growth hormone treatment in the adult: increased bone turnover unmasking occult vitamin D deficiency. In: Endocrine Abstracts: 23rd Joint meeting of the British Endocrine Societies. 2004, Brighton, UK: BioScientifica Ltd.
• Sibal L, Ball SG, Connolly V, James RA, Kane P, Kelly WF, Kendall-Taylor P, Mathias D, Perros P, Quinton R, Vaidya B. Pituitary apoplexy: A review of clinical presentation, management and outcome in 45 cases. Pituitary 2004, 7(3), 157-163.
• Jarvis J, Nag S, Ball SG, Pearce SHS, James RA, Lennard TGW, Bliss R, Neely D, Quinton R. Rapid blockade with sodium ipodate in the pre-surgical management of resistant thyrotoxicosis: a retrospective study. In: 12th International Congress of Endocrinology. 2004, Lisbon: Medimond International Proceedings.
• Velaga MR, Wilson V, Jennings CE, Owen CJ, Herington S, Donaldson PT, Ball SG, James RA, Quinton R, Perros P, Pearce SHS. The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease. Journal of Clinical Endocrinology and Metabolism 2004, 89(11), 5862-5865.
• Barber TM, Cheetham T, Ball SG. X-linked hypopituitarism: clinical and biochemical features of a rare cause of short stature. In: Endocrine Abstracts: 23rd Joint Meeting of the British Endocrine Societies. 2004, Brighton, UK: BioScientifica Ltd.
• Allen LA, Achermann JC, Pakarinen P, Kotlar TJ, Huhtaniemi IT, Jameson JL, Cheetham TD, Ball SG. A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: Clinical and molecular characteristics. Human Reproduction 2003,18 2 251-256.
• James RA, Quinton R, Ball SG. Endocrinology and systemic disease. In: Harris, PE; Bouloux, P-MG, ed. Endocrinology in Clinical Practice. London: Martin Dunitz, 2003, pp. 333-366.
• Ball SG, Barber TM. Molecular development of the pancreatic β cell: Implications for cell replacement therapy. Trends in Endocrinology and Metabolism 2003. ,14 8 349-355.
• Barber TM, Ball SG, Elliot ST. Recurrent ovulation from an ovo-testis in 46XX/47XXY (mosaic)hermaphroditism: serial high-resolution ultrasound characterisation. In: Endocrine Abstracts: 22nd Joint Meeting of the British Endocrine Societies. 2003, Glasgow, UK: BioScientifica Ltd.
• Ball SG, Barber T, Baylis PH. Tests of posterior pituitary function. Journal of Endocrinological Investigation 2003,26 7 15-24.
• Jaiswal V, Baudouin SV, Ball SG. The relationship of on-admission plasma cortisol to outcome in critical illness: a longitudinal prospective study. In: Endocrine Abstracts: 22nd Joint Meeting of the British Endocrine Societies. 2003, Glasgow, UK: BioScientifica Ltd.
• Roberts C, Ball S, Achermann J, Curtis A. Validation of a diagnostic protocol for the detection of mutations in the DAX-1 gene in X-linked adrenal hypoplasia congenita patients. In: Journal of Medical Genetics: British Human Genetics Conference. 2003, York, UK: BMJ Group.
• Jaiswal V, Baudouin SV, Ball SG. A novel gender dimorphism in the response of the gonadal axis to critical illness. In: Endocrine Abstracts: 21st Joint Meeting of the British Endocrine Societies. 2002, Harrogate, UK: BioScientifica Ltd.
• Hannon T, Sturgiss S, Ball SG. Audit of the management of maternal hypothyroidism in pregnancy: implications for service provision. In: Endocrine Abstracts: 21st Joint Meeting of the British Endocrine Societies. 2002, Harrogate, UK: BioScientifica Ltd.
• Baylis PH, Ball SG. Craniopharyngioma. In: Sheppard, M.C., Stewart, P.M, ed. Pituitary Disease. Massachusetts, USA: Springer, 2002, pp.185-206.
• Barber T, Almeida M, Curtis A, Ball SG. Developemnt of a protein truncation test for the detection of DAX-1 mutations in AHC. In: 84th Annual Meeting of the American Endocrine Societies. 2002, San Francisco, California, USA.
• Piper K, Turnpenny LW, Brickwood S, Wilson DI, Ball SG, Hanley NA. Expression profile of PDX1 during human pancreas development. In: 84th Meeting of the American Endocrine Society. 2002, San Francisco, California, USA.
• Senior PA, Barber T, Schmid ML, Ball SG. Hypercalcaemia following systemic mycosis: the role of extra-renal production of 1,25 dihydroxyvitamin D3 by persistant granulomata. In: 84th Annual Meeting of the American Endocrine Society. 2002, San Francisco, California, USA.
• Ball SG. Sodium and water. In: Robinson, S., Meeran, K, ed. Endocrinology: Specialist Handbook. London: Martin Dunitz, 2002, pp.343-374.
• Sibal L, Ugwu P, Kendall-Taylor P, Ball SG, James RA, Pearce SHS, Hall K, Quinton R. Medical therapy of macroprolactinomas in males: I. prevalence of hypopituitarism at diagnosis. II. Proportion of cases exhibiting recovery of pituitary function. Pituitary 2002, 5(4), 243-246.
• Piper K, Ball SG, Keeling JW, Mansoor S, Wilson DI, Hanley NA. Novel SOX9 expression during human pancreas development correlates to abnormalities in Campomelic dysplasia. Mechanisms of Development 2002,116 1-2 223-226.
• Wahid ST, Marbach P, Stolz B, Miller M, James RA, Ball SG. Partial tachyphylaxis to somatostatin (SST) analogues in a patient with acromegaly: The role of SST receptor desensitisation and circulating antibodies to SST analogues. European Journal of Endocrinology 2002,146 3 295-302.
• Ball SG, Baylis PH. The neurohypophysis. In: Wass, J.A.H., Shalet, S.M, ed. Oxford Textbook of Endocrinology and Diabetes. Oxford: Oxford University Press, 2002.
• Adamson KA, Cross I, Batch JA, Rappold GA, Glass IA, Ball SG. Trisomy of the short stature homeobox-containing gene (SHOX), resulting from a duplication-deletion of the X chromosome. Clinical Endocrinology 2002, 56(5), 671-675.
• Hanley NA, Wilson DI, Ball SG. Models to study the developing human endocrine pancreas - stem cells to beta cells. In: 20th Joint Meeting of the British Endocrine Societies. 2001, Belfast, UK.
• Nag S, Perros P, James RA, Ball SG. Rapid blockade with sodium ipodate in the pre-surgical managementof thyrotoxicosis: a retrospective audit. In: 20th Joint Meeting of the British Endocrine Societies. 2001, Belfast, UK.
• Senior PA, Ball SG, Baylis PH, Quinton R. Severe hyperandrogenism with polycythaemia: use of metformin as a therapeutic and diagnostic tool. In: Endocrine Abstracts: 192nd Meeting of the Society for Endocrinology. 2001, London, UK: BioScientifica Ltd.
• Deeb A, Shenton BK, Redfern CPF, Cheetham TD, Ball SG. The effects of growth hormone releasing hormone and its receptor on somatotroph proliferation and cell cycle kinetics in vitro. In: 20th Joint Meeting of the British Endocrine Societies. 2001, Belfast, UK.
• Wahid ST, Hall K, James RA, Ball SG. Ferritin deposition in the pituitary gland and basal ganglia in hereditary haemochromatosis. In: 19th Joint Meeting of the British Endocrine Societies. 2000, Birmingham, UK: Society for Endocrinology.
• Hanley NA, Ball SG. Genes, mice and the internet: Is WT1 the shape of things to come?. Clinical Endocrinology 2000, 52(4), 399-400.
• Basu A, Ball SG, Cross IE, Quinton R. Isodicentric Y-chromosomal abnormality associated with cryptorchidism and severe hypogonadotrophic pubertal delay. Journal of Endocrinology 2000, 164(Supplement), P68.
• Ball SG. MEN-2: who and when to test. In: 19th Joint Meeting of the British Endocrine Societies with the European Federation of Endrocine Societies. 2000, Birmingham, UK: Society for Endocrinology.
• Ball SG, Wahid ST. Polyuria and polydipsia after drug overdose: familial nephrogenic diabtes insipidus presenting in the fourth decade. In: 19th Joint Meeting of the British Endocrine Societies with the European Federation of Endocrine Societies. 2000, Birmingham, UK: Journal of Endocrinology.
• Adamson KA, McKee G, Ball SG. Reversible sensorineural deafness as a presenting feature of severe hypothyroidism. In: 19th Joint Meeting of the British Endocrine Societies. 2000, Birmingham, UK.
• Hanley NA, Hagan DM, Clement-Jones M, Ball SG, Strachan T, Salas-Cortes L, McElreavey K, Lindsay S, Robson S, Bullen P, Ostrer H, Wilson DI. SRY, SOX9, and DAX1 expression patterns during human sex determination and gonadal development. Mechanisms of Development 2000, 91(1-2), 403-407.
• Nanayakkara DKK, Keir MJ, Robinson A, Ball SG. The effect of pretreatment with antithyroid drugs (ATD) on the outcome of both fixed and calculated dose RAI therapy for Graves' disease: a retrospective analysis. In: 19th Joint Meeting of the British Endocrine Societies, with the European Federation of Endrocine Societies. 2000, Birmingham, UK: Society for Endocrinology.
• Renehan AG, Bhaskar P, Painter JE, O'Dwyer ST, Haboubi N, Varma J, Ball SG, Shalet SM. The prevalence and characteristics of colorectal neoplasia in acromegaly. Journal of Clinical Endocrinology and Metabolism 2000, 85(9), 3417-3424.
• Collier A, Watson S, Morris M, Baylis PH, Ball S. Adipsic diabetes insipidus with aversion to drinking: diagnosis and combined pharmacological and psychological treatment. In: 18th Joint Meeting of the British Endocrine Societies. 1999, Bournemouth, UK.
• R. Treacy, L. A. Allen, A. Curtis and S. Ball. Detection of three novel mutations in the DAX-1 gene for X- linked congenital adrenal hypoplasia. Journal of Medical Genetics 1999, 36, S90-S90.
• Connelly KA, Baylis PH, Ball S. Diabetes insipidus presenting in pregnancy. Diagnosis, management and the role of placental vasopressinase in presentation. In: 18th Joint Meeting of the British Endocrine Societies. 1999, Bournemouth, UK.
• N. A. Hanley, S. G. Ball, M. Clement-Jones, D. M. Hagan, T. Strachan, S. Lindsay, S. Robson, H. Ostrer, K. L. Parker and D. I. Wilson. Expression of steroidogenic factor 1 and Wilms' tumour 1 during early human gonadal development and sex determination. Mechanisms of Development 1999, 87, 175-180.
• Adamson KA, Cross I, Sixsmith C, Ball SG. Familial predisposition to variant Turner's syndrome through inheritance of a balanced inversion of an X chromosome. In: 18th Joint Meeting of the British Endocrine Societies. 1999, Bournemouth, UK.
• N. A. Hanley, K. Piper, S. G. Ball, M. Clement-Jones, T. Strachan, J. W. Keeling and D. I. Wilson. High level SOX9 expression during development of the human embryonic pancreas is associated with abnormal islet formation in a case of Campomelic Dysplasia. American Journal of Human Genetics 1999, 65, 966.
• L. M. Allcock, A. B. Dey, I. Gibb, S. Ball, D. Burn and R. A. Kenny. Neurohumoral and cardiovascular responses in Parkinson's disease with orthostatic hypotension. Journal of the American Geriatrics Society 1999, 47, P228.
• Allen L, Cheetham T, Ball S. Novel mutation in DAX-1 in a kindred with congenital adrenal hypoplasia and hypogonadotropic hypogonadism. In: 18th Joint Meeting of the British Endocrine Societies. 1999, Bournemouth, UK.
• Wahid S, Connelly K, James A, Ball S. Osteoblastic hypocalcaemia: clinical, biochemical and radiological features in secondary breast cancer. In: 18th Joint Meeting of the British Endocrine Societies. 1999, Bournemouth, UK.
• Mackin P, Ball SG, Johnson SJ, Lennard TWJ, Proud G. Parathyroid carcinoma: clinical, biochemical and pathological features of three recent cases. In: 18th Joint Meeting of the British Endocrine Societies. 1999, Bournemouth: Journal of Endocrinology.
• Wahid S, Rutter MK, Kendall-Taylor P, James A, Ball S. Pituitary tumour co-secreting adrenocorticophin and prolactin: clinical, biochemical and radiological response to cabergoline. In: 18th Joint Meeting of the British Endocrine Societies. 1999, Bournemouth, UK.
• Padget C, Ball S. Polyuria and polydipsia after head injury in a patient with schizophrenia: post traumatic diabetes insipidus or primary polydipsia?. In: 18th Joint Meeting of the British Endocrine Societies. 1999, Bournemouth, UK.
• Bhasker P, Shenton BK, Varma J, Ball S. The effect of growth hormone on intestinal cell proliferation, cell cycle regulation, and growth factor receptor expression in vitro. In: 18th Joint Meeting of the British Endocrine Societies. 1999.
• P. Bhaskar, I. Brotherick, B. Shenton, J. S. Varma, S. Ball and J. Shrimankar. The use of cytokeratins in the evaluation of colorectal mucosa and tumour cell kinetics by flow cytometry. Gut 1999, 44, TH558.
• Ball SG Baylis PH. Mechanisms of drug induced hyponatraemia. Adverse Drug Reaction Bulletin 1998, 192, 734-737.
• Ball S.G., Sokolov J., Chin W.W. 3,5-Diiodo-L-Thyronine (T2) has selective thyromimetic effects in-vivo and in-vitro. Journal of Molecular Endocrinology 1997, 19, 137-147.
• Ball S.G., Ikeda M., Chin W.W. Deletion of the thyroid hormone beta receptor increases basal and triidothyronine-induction of growth hormone mRNA in GH3 cells. Endocrinology 1997, 138, 3125-3132.
• S. G. Ball, B. Vaidja and P. H. Baylis. Hypothalamic adipsic syndrome: diagnosis and management. Clinical Endocrinology 1997, 47, 405-409.
• S. Ball. Antenatal screening of thyroid antibodies. Lancet 1996, 348, 906-907.
• S. G. Ball, J. M. Davison, A. D. Burt, A. M. McNicol and P. H. Baylis. Cushing's syndrome secondary to ectopic ACTH secretion from a primary ovarian carcinoma. Clinical Endocrinology 1996, 45, 775-778.
• Lanzon-Miller S, Pounder RE, Ball SG, Dalgleish DJ, Coward J, Jackson AO. The effects of famotidine, 40 mg at night, on 24-hour intragastric acidity and plasma gastrin concentration in healthy subjects.. Scand J Gastroenterol 1988, 2, 244-250.
• Murray JS, Baines LA, Pearce SHS, Ball S, Leech N, Wood KM, Kanagasundaram NS. Anti-neutrophil cytoplasmic antibody (ANCA) associated small-vessel vasculitis in a patient with diabetic nephropathy and autoimmune polyendocrinopathy syndrome (APS) type 2: a case report. Clinical Nephrology 2012. In Press.
• Pattman S, Davison A, Ball S. Interpret metanephrine results in light of clinical indications. British Medical Journal 2012, 344, e2456.
• Hanley NA, Rainey WE, Wilson DI, Ball SG, Parker KL. Expression profiles of SF-1, DAX1, and CYP17 in the human fetal adrenal gland: Potential interactions in gene regulation. Molecular Endocrinology 2001, 15(1), 57-68.