The Bio-Imaging Unit operates several sites across the University, and provides a wide range of state-of-the-art microscopy equipment.
Imaging capabilities available in the Facility include: conventional brightfield; phase; DIC and widefield-fluorescence; and confocal microscopy.
The Bioinformatics Support Unit (BSU) provides data analysis and experimental design services for next-generation sequencing, microarrays, proteomics and more.
The BSU has expertise in a range of areas, including: high-throughput sequence analysis; microarray analysis; proteomics analysis.
Electron MicroscopyElectron Microscopy
Electron Microscopy Research Services has a range of specialist equipment for imaging specimens from both biological and material sciences.
The primary services available are:
- Transmission Electron Microscopy (TEM)
- Scanning Electron Microscopy (SEM)
- Gatan 3view
Flow CytometryFlow Cytometry
The Flow Cytometry Core Facility provides a comprehensive service and houses a large range of high quality equipment, including:
- cell sorters and analysers for performing fluorescence cytometry
- a Helios Cytof Mass Cytometer
- Seahorse XF analsyer systems for assising metabolic activity
The Genomics Core Facility supports and delivers cutting-edge genomics research, designed with single-cell sequencing and medium-scale genomics in mind. The Facility's instrumentation set-up allows for a high level of service flexibility, as it is able to be rapidly shifted between genomic, transcriptomic and epigenomic sample analysis.
High Throughput ScreeningHigh Throughput Screening
The High Throughput Screening Facility uses state of the art equipment and biological reagents to cater for researchers working with both mammalian and microbial cell-based systems, and enables the rapid identification of novel targets.
Infectious DiseasesInfectious Diseases
Newcastle University Infectious Diseases Facility provides containment facilities for the safe use and handling of infectious microbiological agents. With two laboratory suites dedicated to the research of HG3 pathogens, the Facility provides the opportunity for scientists to include Hazard Group 3 (HG3) and Specified Animal Pathogen Order Group 3 pathogens in their research.
Preclinical In Vivo ImagingPreclinical In Vivo Imaging
Newcastle Preclinical In Vivo Imagining (PIVI) is a multidisciplinary research centre providing equipment for Magnetic Resonance, Positron Emission Tomography and Fluorescence/Bioluminescence imaging. The Facility provides a range of services and training, from experimental design and data acquisition, to data analysis.
Protein and Proteome AnalysisProtein and Proteome Analysis
Newcastle University Protein and Proteome Analysis (NUPPA) provides a range of services including: identifying single proteins and proteins in complex protein mixtures; characterising proteins; finding post-translational modifications; quantifying proteins.
The latest addition to NUPPA is the Protein Production Unit, adding further expertise and equipment in the production and characterisation of recombinant proteins in prokaryotic host organisms.
Facilities for Clinical Research
Newcastle University operates in partnership with the Newcastle upon Tyne Hospitals Trust through a number of facilities, in order to deliver clinical research as part of the Newcastle Academic Health Partners.
Biomarker Assay ServiceBiomarker Assay Service
The Biomarker Assay Service is regularly involved in clinical ageing research. Services include: handling of blood samples; generation of suitable conditioned material aliquots for further analysis; analysis of white blood cells; DNA damage and repair capability; telomere length measurements by qPCR and ApoE genotyping.
Cancer Trials Research CentreCancer Trials Research Centre
The Sir Bobby Robson Cancer Trials Research Centre carries out all phases of cancer trials, coordinates North of England Cancer Network studies, and is an integral part of the Newcastle Experimental Cancer Medicine Centre.
Based in the regional Northern Centre for Cancer Care at the Freeman Hospital, the Centre is a designated unit for the administration of first in human experimental cancer drugs. The staff are highly experienced in the regulatory submission and running of clinical trials, and a dedicated clinical trials pharmacy ensures safe handling and monitoring of experimental agents.
Cellular Therapies FacilityCellular Therapies Facility
The Newcastle Cellular Therapies Facility is an MHRA licensed clean room complex designed specifically for the production of cellular therapies.
The Facility operates in partnership between Newcastle University and the Newcastle upon Tyne Hospitals NHS Foundation Trust, enabling not only research and manufacture, but also the delivery of cell therapy clinical trials.
Clinical Ageing Research UnitClinical Ageing Research Unit
The Clinical Ageing Research Unit (CARU) facilitates the development of early assessment and intervention strategies targeted at age-associated degenerative conditions. CARU provides a ‘one stop shop’ for investigators planning, designing, conducting and analysing trials and other high quality clinical research studies.
Clinical Research FacilityClinical Research Facility
The Clinical Research Facility (CRF) is a collaboration between Newcastle University and Newcastle upon Tyne Hospitals NHS Foundation Trust. The CRF's highly-trained staff are capable of setting up, negotiating and delivering all phases of clinical trials in accordance with Good Clinical Practice Standards.
Dental Clinical Research FacilityDental Clinical Research Facility
The Dental Clinical Research Facility is a dedicated clinical research environment, comprising four fully-equipped dental surgeries. The Facility has a full range of clinical dental research capabilities, including: restorative dentistry; endodontics; periodontics; implant research; dental materials research; paediatric dentistry.
Clinical Trials UnitClinical Trials Unit
The Newcastle Clinical Trials Unit has a vision to facilitate world class clinical trials that impact understanding of human disease and lead to improved diagnostics and therapeutics for patient benefit. The NCTU works in partnership with investigators across all disease types, phases of research and methodologies in order to deliver high quality research.
Magnetic Resonance CentreMagnetic Resonance Centre
The Newcastle Magnetic Resonance Centre aims to develop and apply novel, non-invasive magnetic resonance methodology to solve important problems of human health.
The Centre is equipped with two high field strength magnetic resonance scanners, and has full facilities throughout for clinical MR research and associated technical developments.
Positron Emission Tomography CentrePositron Emission Tomography Centre
The Newcastle Positron Emission Tomography (PET) Centre is equipped with the latest generation of PET-MR scanners and a PET-CT scanner which provide excellent quality imaging. In both imaging suites there are additional features required for radiotherapy planning, injection of contrast agents and for respiratory gating.
Behaviour and EvolutionBehaviour and Evolution
The Centre for Behaviour and Evolution (CBE) is a cross-faculty research centre, uniting researchers with a common goal of understanding animal behaviour, including that of humans.
The Centre's research makes use of a wide range of facilities in and around Newcastle University, including laboratories and field sites.
There are also a suite of climate controlled chambers for behavioural and phsiological experiments.
Newcastle Biobanks store a wide range of samples for use in medical research, which are derived from a range of disease areas, including: cancer; mitochondrial disease; orthopaedics; neurodegenerative disease.
Biobank staff also offer a wide range of services and facilities to support researchers with their work.
Colour Vision Testing ServicesColour Vision Testing Services
Colour Vision Testing Services provides testing in human and animal perception and behaviour. Using a comprehensive battery of both clinical tests and more sophisticated tests initially developed for research purposes, the service offers testing and disgnosis of colour vision deficencies.
Electroencephalography (EEG)Electroencephalography (EEG)
Electroencephalography (EEG) is a simple, painless, non-invasive technique which measures brain activity from small recording electrodes placed on the scalp either individually or by means of specially designed electrode caps.
As a research tool EEG is very helpful in identifying interactions between different cortical brain areas and as a diagnostic tool it can be used to detect abnormal brain activity.
High Field MRIHigh Field MRI
The Institute of Neuroscience operates an actively shielded high field (4.7 Tesla) vertical bore Magnetic Resonance Imaging (MRI) scanner (Bruker Biospec 47/60 VAS).
The system can be used for imaging of a range of biological specimens, including functional activation studies of small laboratory animals, complete with full life signs monitoring and full veterinary support (if required, at additional cost), or imaging of post-mortem tissue.
Human Developmental Biology ResourceHuman Developmental Biology Resource
The Human Developmental Biology Resource (HDBR) is an ongoing collection of human embryonic and fetal material ranging from 3 to 20 weeks of development.
Tissue, slides, RNA/DNA and tissue arrays are available to the international scientific community.
Muscle Performance and Exercise Training LaboratoryMuscle Performance and Exercise Training Laboratory
The Muscle Performance and Exercise Training Laboratory is one of the only clinically qualified research laboratories for the evaluation of muscle performance, physical fitness and physical activity in the UK.
The facility combines state-of-the-art measurement equipment for physical fitness, cardiac function, muscle strength, and body composition, alongside a physical activity and exercise intervention delivery team.
NanoString nCounter Analysis SystemNanoString nCounter Analysis System
Newcastle Nanostring is a technician-run service with specialist advice available.
The NanoString nCounter analysis system is the first and only platform that can deliver direct profiling of individual molecules in a highly multiplexed single reaction without any need for amplification. Critically, NanoString technology is superior to any other current RNA analysis technique for FFPE-derived material.
Single Cell UnitSingle Cell Unit
Newcastle University Single Cell Unit (NUSCU) is an MRC and University funded initiative.
NUSCU is an integrated facility buttressed by five cores: genomics, flow cytometry, bioimaging, high throughput/automation and bioinformatics that will collectively provide cutting-edge instrumentation, expertise and technical support for researchers.
Oral Health ResearchOral Health Research
The Centre for Oral Health Research offers a range of research laboratories, which support research in translational oral biosciences and dental materials.
The Centre comprises a number of individual Facilities: