Newcastle Liver Research Group

The group is internationally recognised in the field of liver research.

Theme Leader

Professor Derek Mann (Head of Research Group) and Dr Quentin M. Anstee (Clinical Research Lead)

Major Research Themes

The Newcastle Liver Research Group maintains critical mass to support on-going research in the field of hepatology, genetics and liver biology and provides a forum to support bi-directional translational research and collaboration.


With a membership comprising basic-scientists and clinician-scientists, the liver research group provides a forum for 'cross-pollination' of ideas between related disciplines. This grouping has already successfully translated a number of basic research projects 'to the bedside' where clinical trials are on-going examining novel anti-fibrotic approaches to slow fibrosis in fatty liver disease.

Members of the group are advancing research in the fields of:

  • non-alcoholic fatty liver disease (NAFLD)
  • primary biliary cirrhosis (PBC)
  • alcoholic liver disease
  • hepatocellular carcinoma (HCC)
  • genetic and epigenetic modifiers of liver disease severity (in patient cohorts and animal models)
  • tissue fibrosis

Within these areas we are leaders in several national and international clinical research collaborations including the ‘UK Genetics of Liver Disease’ (UK GoLD) consortium, ‘Fatty Liver Inhibition of Progression’ (FLIP) consortium and the ‘UK-PBC’ consortium.

Related Websites

Staff List


Dr Quentin Anstee
Clinical Senior Lecturer & Consultant Hepatologist

Professor Margaret Bassendine

  • Telephone: +44 (0) 191 213 7208

Professor Alastair Burt
Associate Clinical Researcher

Professor Ann Daly
Professor of Pharmacogenetics and Associate Dean for Internationalisation (Faculty of Medical Sciences)

Professor Chris Day
PVC of Medical Sciences

Dr Peter Donaldson
Senior Lecturer

Professor David Jones
Professor of Liver Immunology

Professor John Kirby
Dean of PG Studies

Professor Derek Manas
Hon Clin Prof of Transplantation

Dr Jelena Mann
Reader in Epigenetics

Professor Derek Mann
Prof of Hepatology

Dr Fiona Oakley
Reader in Fibrosis Biology

Dr Helen Reeves
Senior Lecturer & Honorary Consultant Gastroenterologist at Newcastle Hospitals NHS Foundation Trust

Professor Geoff Toms

Professor Matthew Wright
Professor of Toxicology