The group is internationally recognised in the field of liver research.

Theme Leader

Professor Derek Mann (Head of Research Group) and Dr Quentin M. Anstee (Clinical Research Lead)

Major Research Themes

The Newcastle Liver Research Group maintains critical mass to support on-going research in the field of hepatology, genetics and liver biology and provides a forum to support bi-directional translational research and collaboration.

Expertise

With a membership comprising basic-scientists and clinician-scientists, the liver research group provides a forum for 'cross-pollination' of ideas between related disciplines. This grouping has already successfully translated a number of basic research projects 'to the bedside' where clinical trials are on-going examining novel anti-fibrotic approaches to slow fibrosis in fatty liver disease.

Members of the group are advancing research in the fields of:

• non-alcoholic fatty liver disease (NAFLD)
• primary biliary cirrhosis (PBC)
• alcoholic liver disease
• hepatocellular carcinoma (HCC)
• genetic and epigenetic modifiers of liver disease severity (in patient cohorts and animal models)
• tissue fibrosis

Within these areas we are leaders in several national and international clinical research collaborations including the ‘UK Genetics of Liver Disease’ (UK GoLD) consortium, ‘Fatty Liver Inhibition of Progression’ (FLIP) consortium and the ‘UK-PBC’ consortium.

Related Websites

• Institute of Cellular Medicine

Staff List