Faculty of Medical Sciences

Staff Profile

Dr Anja Krippner-Heidenreich

Associate Fellow

Background

Qualifications

Dr. rer. nat., Medical School Hannover, Germany, 1999

Diploma in Biology, Georg August University Goettingen, Germany, 1995

Previous Positions

Postoctoral Fellow in the Institute of Cell Biology and Immunology at the University Stuttgart, Germany, 2000-2007

Graduate Student in the Institute of Molecular Biology at the Medical School in Hannover, Germany, 1996-1999

Student at The Scripps Research Institute, San Diego, U.S.A., 1993-1996

Languages

  • German
  • English
  • Latin (elementary proficiency)
  • French (elementary proficiency)

 

Research

Research Interests

--- Immunoregulation and cell death induction in cancer with focus on T cell acute lymphoblastic leukeamia---

My research focusses on mechanisms in cell signalling regulating cell death, proliferation and survival of cancer and immune cells and their translation into new therapeutic concepts with a current emphasis on T cell acute lymphoblastic leukaemia (T-ALL) and sarcoma.

Approaches include the identification of key molecules central for the survival of cancer cells and the use of direct, targeted and receptor-selective death receptor-ligands such as TNF and TRAIL for direct and specifically induction of cell death in cancer cells.  

We use in vitro and in vivo shRNA and CRISPR screens, test novel drug regimens in patient-derived material in clinically relevant co-culture and xenotransplantation settings and apply detailed mechanistic analyses using conventional molecular and biochemical methods to develop new therapeutic options for cancer.


Postgraduate Supervision

Supervision of postdocs, research assistants, PhD and MRes students

Funding

German Research Council (Deutsche Forschungsgemeinschaft, DFG)

JGW Patterson Foundation 

Patents

Krippner-Heidenreich A, Grunwald I, Scheurich P, Pfizenmaier K: Polypetides of the members of the TNF ligand family and use thereof. 2005235669; 24.03.2005

Publications