Professor Calum McNeil
Professor of Biological Sensor Systems
- Personal Website: http://www.ncl.ac.uk/medicalsciences/research/groups/diagnostic/
- Address: Diagnostic & Therapeutic Technologies
Institute of Cellular Medicine
Newcastle upon Tyne
The work of the Diagnostic & Therapeutic Technologies Research Group (D&TT) is targeted towards Healthcare Engineering, Science and Technology. The overall aim is to improve rapid clinical diagnostic technologies and to engineer technological approaches which can help to elucidate the molecular pathways that cause degenerative diseases. This work involves the design and development of highly specific 'bioelectronic' interfaces between inorganic surfaces and biological species (antibodies, microbial cells, enzymes and redox proteins) and has led to the production of a number of electrochemical, optical and microelectromechanical sensor systems capable of the direct, rapid measurement of biological and chemical species in complex matrices. The current research programmes being carried out by the D&TT group can be broadly defined in three inter-related, multi-disciplinary areas. These are:
- Development of sensors for rapid, specific identification of bacterial infection and AMR based on electrical impedance, optoelectronic and microelectromechanical systems (MEMS). - Collaboration with Dr Neil Keegan.
- Development of near-patient technology platforms for rapid, quantitative immunometric measurement of biochemical markers of disease and their use in remote monitoring and management of chronic diseases.
- Development of multi-analyte sensor array platforms for direct, simultaneous intra- and extra-cellular monitoring of reactive oxygen species and the application of these to understanding related biochemical mechanisms involved in neurological disease processes. - Collaboration with Dr Phil Manning.
Our work has been highlighted in a number of public engagement and outreach activities including producing news items and videos aimed at public education of the D&TT vision of successful outcomes of collaborative multi-disciplinary research and also using social media to highlight achievements.
Current Major Research Funding
The Multi-Corder: EPSRC Programme Grant (£3.4M, May 2013 - April 2018).
Early-Warning Sensing Systems for Infectious Diseases (i-sense): EPSRC IRC (£11.1M, Oct 2013 - Sept 2019).
Personal Risk Assessment in Febrile Illness to Optimize Real-life Management Across the EU (PERFORM): EC H2020 (Jan 2016 - Dec 2020).
Ultra-Sensitive Enhanced Nano-Sensing of Antimicrobial Resistance (u-Sense): EPSRC IRC Plus Project (£1.39M, Oct 2018 - Sept 2022).
- Jauset-Rubio M, Svobodová M, Mairal T, McNeil C, Keegan N, Saeed A, Abbas MN, El-Shahawi MS, Bashammakh AS, Alyoubi AO, O'Sullivan CK. Ultrasensitive, rapid and inexpensive detection of DNA using paper based lateral flow assay. Scientific Reports 2016, 6, 37732.
- Jauset-Rubio M, Svobodová M, Mairal T, McNeil C, Keegan N, El-Shahawi MS, Bashammakh AS, Alyoubi AO, O'Sullivan CK. Aptamer Lateral Flow Assays for Ultrasensitive Detection of β-Conglutin Combining Recombinase Polymerase Amplification and Tailed Primers. Analytical Chemistry 2016, 88(21), 10701–10709.
- Sanchez JLA, Fragoso A, Joda H, Suarez G, McNeil CJ, O'Sullivan C. Site-directed introduction of disulfide groups on antibodies for highly sensitive immunosensors. Analytical and Bioanalytical Chemistry 2016, 408(19), 5337-5346.
- Shakoor A, Cheah BC, Hao D, Al-Rawhani M, Nagy B, Grant J, Dale C, Keegan N, McNeil C, Cumming DRS. Monolithic integration of a plasmonic sensor with CMOS technology. In: Smart Photonic and Optoelectronic Integrated Circuits XIX. 2017, San Francisco: SPIE.
- Shakoor A, Cheah BC, Hao D, Al-Rawhani M, Nagy B, Grant J, Dale C, Keegan N, McNeil C, Cumming DRS. Plasmonic Sensor Monolithically Integrated with a CMOS Photodiode. ACS Photonics 2016, 3(10), 1926–1933.
- Hu Z, Hedley J, Keegan N, Spoors J, Gallacher B, McNeil C. One-port Electronic Detection Strategies for Improving Sensitivity in Piezoelectric Resonant Sensor Measurements. Sensors 2016, 16(11), 1781.
- Orr J G., Homer T, Ternent L, Newton J, McNeil C J., Hudson M, Jones D E.J. 'Health Related Quality of Life in People with Advanced Chronic Liver Disease'. Journal of Hepatology 2014, 61(5), 1158–1165.
- Ortiz P, Burnett R, Keegan N, Spoors J, Hedley J, Harris A, Burdess J, Raphoz N, Collet J, McNeil CJ. Issues associated with scaling up production of a lab demonstrated MEMS mass sensor. Journal of Micromechanics and Microengineering 2012, 22(11), 115032.
- Burnett R, Harris AJ, Ortiz P, Hedley J, Burdess JS, Keegan N, Spoors JA, McNeil CJ. Electronic Detection Strategies for a MEMS-Based Biosensor. Journal of Microelectromechanical Systems 2013, 22(2), 276-284.
- Ismail AK, Burdess JS, Harris AJ, Suarez G, Keegan N, Spoors JA, Chang SC, McNeil CJ, Hedley J. The fabrication, characterization and testing of a MEMS circular diaphragm mass sensor. Journal of Micromechanics and Microengineering 2008, 18(2), 025021.
- Ismail AK, Burdess JS, Harris AJ, McNeil CJ, Hedley J, Chang SC, Suarez G. The principle of a MEMS circular diaphragm mass sensor. Journal of Micromechanics and Microengineering 2006, 16(8), 1487-1493.
- Govindarajan S, McNeil CJ, Lowry JP, McMahon CP, O'Neill RD. Highly selective and stable microdisc biosensors for l-glutamate monitoring. Sensors and Actuators B: Chemical 2013, 178, 606–614.
- Suarez G, Keegan N, Spoors JA, Ortiz P, Jackson RJ, Hedley J, Borrise X, McNeil CJ. Biomolecule Patterning on Analytical Devices: A Microfabrication-Compatible Approach. Langmuir 2010, 26(8), 6071-6077.
- Suarez G, Jackson RJ, Spoors JA, McNeil CJ. Chemical introduction of disulfide groups on glycoproteins: A direct protein anchoring scenario. Analytical Chemistry 2007, 79(5), 1961-1969.
- Ortiz P, Keegan N, Spoors J, Hedley J, Harris A, Burdess J, Burnett R, Velten T, Biehl M, Knoll T, Haberer W, Solomon M, Campitelli A, McNeil C. A hybrid MEMS-based microfluidic system for cancer diagnosis. In: Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems. 2008, Melbourne, Australia: SPIE.
- Ortiz P, Keegan N, Spoors J, Hedley J, Harris A, Burdess J, Burnett R, Velten T, Biehl M, Knoll T, Haberer W, Solomon M, Campitelli A, McNeil C. Integration of a bioMEMS device into a disposable microfluidic cartridge for medical diagnostics. In: Microfluidics, BioMEMS, and Medical Microsystems VII. 2009, San Jose, California, USA: SPIE.
- Rana S, Page RH, McNeil CJ. Comparison of Planar and 3-D Interdigitated Electrodes as Electrochemical Impedance Biosensors. Electroanalysis 2011, 23(10), 2485-2490.
- Rana S, Page RH, McNeil CJ. Impedance spectra analysis to characterize interdigitated electrodes as electrochemical sensors. Electrochimica Acta 2011, 56(24), 8559-8563.
- Rana S, Gregoratto I, Ortiz PM, Harris AJ, Burdess JS, McNeil CJ. Accurate Surface-to-Bulk Feature Alignment and Feature Size Preservation During Double-Sided Wafer Processing Using C4F8 Plasma Polymer for the Fabrication of Electrostatically Actuated Cantilever Devices. Journal of Microelectromechanical Systems 2010, 19(4), 871-877.
- Rana SD, Ortiz PM, Harris AJ, Burdess JS, McNeil CJ. An electrostatically actuated cantilever device capable of accurately calibrating the cantilever on-chip for AFM-like applications. Journal of Micromechanics and Microengineering 2009, 19(4), 045012.
- Manning P, McNeil CJ. Electrochemical and optical sensing of reactive oxygen species: pathway to an integrated intracellular and extracellular measurement platform. Biochemical Society Transactions 2011, 39, 1288-1292.
- Boulton SJ, Keane PC, Morris CM, McNeil CJ, Manning P. Real-time monitoring of superoxide generation and cytotoxicity in neuroblastoma mitochondria induced by 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline. Redox Report 2012, 17(3), 108-114.
- Henderson JR, Fulton DA, McNeil CJ, Manning P. The development and in vitro characterisation of an intracellular nanosensor responsive to reactive oxygen species. Biosensors and Bioelectronics 2009, 24(12), 3608-3614.
- Henderson JR, Swalwell H, Boulton S, Manning P, McNeil CJ, Birch-Machin MA. Direct, real-time monitoring of superoxide generation in isolated mitochondria. Free Radical Research 2009, 43(9), 796-802.