Dr Hannah Elliott
- Telephone: 0191 241 8636
My primary research interest is aimed at understanding the role of DNA methylation in disease risk. My research uses a number of complementary methods including genome-wide methylation arrays and high throughput quantitative methods (Pyrosequencing and Sequenom EpiTYPER). Research is complemented by bioinformatic and statistical analysis.
Current research activities are:
A program of epigenetic research in the Avon Longitudinal Study of Parents and Children
This research activity focuses on the identification and validation of epigenetic variation within the ALSPAC cohort. Specific aims include investigation of longitudinal changes in DNA methylation and the use of peripheral blood lymphocyte DNA in the cohort
Epigenetic variation in insulin sensitivity, type 2 diabetes and ethnicity
People of Indian Asian descent are more likely to develop type 2 diabetes than the general population. This research compares DNA methylation signatures of European and Indian individuals in genes identified from genome-wide association studies. It also investigates SNP variation and its effect on local methylation.
The role of DNA methylation in mitochondrial disorders
Leber’s Hereditary Optic Neuropathy (LHON) is a common mitochondrial disorder characterised by loss of central vision. Not all mutation carriers develop the disease and the reasons for this are unclear, although smoking has been identified as one precipitant. This research involves measuring DNA methylation of the nuclear and mitochondrial genome to identify and explore differences between those with LHON phenotype and unaffected carriers.
- Chinnery PF, Elliott HR, Hudson G, Samuels DC, Relton CL. Epigenetics, epidemiology and mitochondrial DNA diseases. International Journal of Epidemiology 2012, 41(1), 177-187.
- Pfeffer G, Griffin H, Elliott H, Straub V, Baresi R, Udd B, Chinnery PF. Exome sequencing in three families with cytoplasmic body myopathy with early respiratory failure. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
- Swingler TE, Wheeler G, Carmont V, Elliott HR, Barter MJ, Abu-Elmagd M, Donell ST, Boot-Handford RP, Hajihosseini MK, Münsterberg A, Dalmay T, Young DA, Clark IM. The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis and Rheumatism 2012, 64(6), 1909-1919.
- Pfeffer G, Elliott HR, Griffin H, Barresi R, Miller J, Marsh J, Evilä A, Vihola A, Hackman P, Straub V, Dick DJ, Horvath R, Santibanez-Koref M, Udd B, Chinnery PF. Titin mutation segregates with hereditary myopathy with early respiratory failure. Brain 2012, 135(6), 1695-1713.
- Groom A, Elliott HR, Embleton ND, Relton CL. Epigenetics and child health: basic principles. Archives of Disease in Childhood 2011, 96, 863-869.
- Chinnery PF, Elliott HR, Syed A, Rothwell PM, Oxford Vascular Study. Mitochondrial DNA haplogroups and risk of transient ischaemic attack and ischaemic stroke: a genetic association study. Lancet Neurology 2010, 9(5), 498-503.
- Kent L, Gallagher L, Elliott HR, Mowbray C, Chinnery PF. An investigation of mitochondrial haplogroups in autism. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics 2008, 147(6), 987-989.
- Elliott HR, Samuels DC, Eden JA, Relton CL, Chinnery PF. Pathogenic Mitochondrial DNA Mutations Are Common in the General Population. American Journal of Human Genetics 2008, 83(2), 254-260.
- Craig K, Elliott HR, Keers SM, Lambert C, Pyle A, Graves TD, Woodward C, Sweeney MG, Davis MB, Hanna MG, Chinnery PF. Episodic ataxia and hemiplegia caused by the 8993T→C mitochondrial DNA mutation. Journal of Medical Genetics 2007, 44(12), 797-799.
- Chinnery PF, Mowbray C, Elliott H, Elson JL, Nixon H, Hartley J, Shaw PJ. Mitochondrial DNA haplogroups and amyotrophic lateral sclerosis. Neurogenetics 2007, 8(1), 65-67.
- Kent L, Lambert C, Pyle A, Elliott H, Wheelwright S, Baron-Cohen S, Chinnery PF. The Mitochondrial DNA A3243A>G Mutation Must Be An Infrequent Cause Of Asperger Syndrome. Journal of Pediatrics 2006, 149(2), 280-280.
- Chinnery PF, Elliott HR, Patel S, Lambert C, Keers SM, Durham SE, McCarthy MI, Hitman GA, Hattersley AT, Walker M. Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes. Lancet 2005, 366(9497), 1650-1651.