Faculty of Medical Sciences

Staff Profile

Professor Fai Ng

Professor of Rheumatology

Background

Qualifications

M.A., Ph.D., FRCP, CCT (Rheumatology)


 Role and Responsibilities

- Professor of Rheumatology, Newcastle University

- Honorary Consultant Rheumatologist, Newcastle upon TyneHospitals NHS Foundation Trust


- Deputy director, Clinical Research Facility, Royal Victoria Infirmary

 - Co-director, Arthritis Research UK Newcastle Biomedicine Experimental Arthritis Treatment Centre

Memberships

- Royal College of Physicians, London

- British Society for Rheumatology

- British Society for Immunology


 Honours and Awards

- Michael Mason Prize, British Society for Rheumatology (2015)

- MRC Clinician Scientist (2006-11, not taken up)

- Runner-up, Young Investigator Award, Medical Research Society (2002)

- Runner-up, Barbara Ansell Prize, Royal Society of Medicine (2003)

- Medawar Medal Finalist, British Society for Transplantation (2001)

- Wellcome Trust Training Fellowship (1998-2001)


 

External Roles

- Expert panel, European League Against Rheumatism (EULAR) Sjogren's Syndrome Study Group

- Steering Committee, EULAR Best Practice in the Management of Sjogren's Syndrome Group 

- Previously Clinical lead, Northumberland, Tyne and Wear Comprehensive Local Research Network (CLRN) Musculoskeletal Specialty Group

- Committee Member of Arthritis Research UK Autoimmune Rheumatic Diseases Clinical Study Group

- Medical Council, British Sjogren's Syndrome Association 

- Associate Editor, Rheumatology (OUP)

- Co-convenor, EULAR Sjogren's syndrome experimental and investigative alliance (eSSENTIAL)

Research

Research Interests

To understand the cellular and moelcular mechanisms of autoimmunity and its regulation, with particular reference to their relationship to clinical phenotypes/features (such as fatigue, lymphoma development, disease activity) in autoimmune rheumatic diseases such as primary Sjogren's syndrome and rheumatoid arthritis, and to translate this knowledge into strategies to improve the diagnosis and treatment of autoimmune disease.

Other Expertise

Sjogren's syndrome; fatigue, lymphoma

Current Work

1. To set up a UKcohort and biobank of patients with Primary Sjogren's syndrome - the UK primary Sjogren's syndrome registry (www.sjogrensregistry.org)
2. To understand the pathophysiological mechanisms of primary Sjogren's syndrome, particularly the link to the symptom of fatigue and lymphoma risk.

3. To understand the role of microRNA in the pathogenesis of lymphoma
4. To develop stratified medicine approach in the management of primary Sjogren's syndrome

5. To develop effective non-pharmacological management of fatigue for patients with primary Sjogren's syndrome

Longer term goals:

1. To develop a comprehensive basic and translational research programme of primary Sjogren's syndrome
2. To develop an international collborative network of Sjogren's cohort and biobank

Research Roles

Principle investigator

Principle investigator for academic-led and industry-led clinical trials 

Committee member and Sjogren's representative, Arthritis Research UK Autoimmune Rheumatic Diseases sub-committee 

Postgraduate Supervision

PhD students and MRes/MSc students

Esteem Indicators

Wellcome Trust Training Fellowship (1998-2001)
MRC Clinician Scientist (2006, not taken up)
Expert Panel Member, EULAR Sjogren's syndrome study group
Trustee and Medical Council Member, British Sjogren's Syndrome Association

Michael Mason Prize, British Society for Rheumatology

Funding

Current:

MRC patient cohort initiative (2008-14)

MRC project grant (2012-16)

Arthritis Research UK project grant

NIHR FSF (2012-13)

Arthritis Research UK Doctoral Fellowship (2013-17)

Medical Research Council - DPFS grant (Co-investigator)

MRC experimental medicine grant (Co-I)

MRC project grant (Co-I)

Horizon2020 project grant (Co-I)

Research Capability Cluster (Co-investigator)  

Arthritis Research UK Experimental Arthritis Treatment Centre (Co-investigator) 

Arthritis Research UK  Centre of Excellence in rheumatoid arthritis (Co-investigator)

Past:

arc Clinical Senior Lecturership in Rheumatology (current)
arc Project grant (Co-investigator)
Wellcome Trust Training Fellowship (1998-2001)
arc PhD studentship (Oct 2007 - Sep 2010)
JGWP Foundation Trust Project Grant (2007-8, 2008-10, 2011-12)

British Sjogren's Syndrome Association project grant (2009-12)

Sir Jules Thorn PhD Scholarship (2010-2013)  
 

Teaching

Undergraduate Teaching

Musculoskeletal medicine - medical students

Sjogren's syndrome - Dental Students 

Personal tutor for medical students 

Postgraduate Teaching

M.Res in Musculoskeletal Medicine

Core Medical Trainees, NUTH 

Specialist trainees in Rheumatology

Publications