Module Catalogue

ONC8019 : Pharmacology of Chemotherapeutic Agents (E-learning)

  • Offered for Year: 2017/18
  • Module Leader(s): Prof. Nicola Curtin
  • Lecturer: Dr David Jamieson
  • Owning School: FMS Graduate School
  • Teaching Location: Off Campus
Semesters
Semester 1 Credit Value: 20
ECTS Credits: 10.0

Aims

The module explores the concepts underlying the pharmacological principles that govern the use of drugs in the treatment of cancer. The students will gain a detailed understanding of the mechanisms of action and resistance that underlie antitumour effects and toxicities of the drugs to treat cancer.

Outline Of Syllabus

This module includes the following topics:
•Hallmarks of cancer and targets of therapy
•Introduction to chemotherapy
•Principles of Pharmacokinetics and Pharmacodynamics of Anticancer drugs
•Alkylating agents and platinums
•Antimitotics
•Antimetabolites
•Topoisomerase I and II poisons
•Hormonal therapies
•Antibody-based therapies
•Immunotherapy
•Tyrosine kinase inhibitors
•Drug resistance

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Guided Independent StudyAssessment preparation and completion310:0030:00N/A
Guided Independent StudyDirected research and reading126:0072:00Online content
Guided Independent StudySkills practice12:002:00Software
Guided Independent StudyReflective learning activity222:0044:00eJournal and Discussion board
Guided Independent StudyIndependent study134:0052:00Supplemental reading
Total200:00
Teaching Rationale And Relationship

Through a series of online tutorials (including videos and recapped PowerPoint presentations) as well as private study (including directed reading), students will gain detailed knowledge and understanding of the basic principles of chemotherapy and pharmacology ; chemotherapeutic, hormonal and targeted treatments for cancer, according to their mechanisms of action; and principles and mechanisms of tumour resistance to drug treatment. Furthermore, students will be encouraged to participate in collaborative learning via the discussion board. Personal development will be encouraged through the use of reflective journal postings, shared only with the module leaders. As the students proceed through the module, they will complete a number of interactive activities that will help to consolidate their understanding of the curriculum. The data compiled will guide their summative assessments.

This will facilitate the development of interpersonal and communication skills as well as team working and peer assessment skills.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Oral Presentation101M60Recorded Power Point presentation (maximum 10 Minutes)
PC Examination601M30Online MCQ (Max 1hr - 30 questions)
Other Assessment
Description Semester When Set Percentage Comment
Portfolio1M10Participation in collaborative e-learning activities throughout the module.
Formative Assessments
Description Semester When Set Comment
Computer assessment1MWeekly MCQs for each topic
Assessment Rationale And Relationship

The presentation will require students to demonstrate their understanding of a chosen example of a major classes of chemotherapeutic agents and discuss clinical use, toxicities and mechanisms of resistance. The presentation will assess the students' ability to synthesise data and present information succinctly and in a visual format.
This will consolidate the students’ newly acquired knowledge across the whole range of the module as well as their ability to process information.

Multiple choice questions (formative) will help to promote reflection in students in order to identify areas of strength, weakness or misunderstanding. MCQs (summative) will probe specific points of understanding and knowledge of the students across the module.

A participation grade is included to encourage and reward the student's engagement with the
collaborative activities.

Should a student fail the participation assessment and have to undertake a re-sit they will have to
complete a different form of assessment. The student will be asked to look at 2 participation
activities as identified by the module leader/team and submit a 500 word written summary (approx. 250 words per activity).

Reading Lists

Timetable