Our aim is to assess human exposure to chemicals and their metabolites (biomarkers of exposure) and develop, evaluate and use existing and new biomarkers of toxicity (biomarkers of effect).
- Reference range study (R Jefferson, PG Blain, M Dunn, DB Henderson, S Rushton, HPA)
There is currently little or no information regarding the levels of environmental chemicals in the blood and urine of any population base within the UK. Rather than predicting how much of a substance gets into people from estimates based on measurements in food, water, air, and other media, the reference range study aims to measure low levels of chemicals that are actually in people’s bodies. The overall purpose of this study is to provide unique exposure information to scientists, physicians, public health practitioners and other stakeholders e.g. Department of Health, to help prevent disease that results from exposure to environmental chemicals.
- Robust bio-monitoring methods for detecting chemical agent exposure (D Vidler, FM Williams, PG Blain, Home Office)
The purpose of this study is to evaluate, and develop, rapid and robust analytical methods for the detection and quantification of nerve agent exposures in humans, following an accidental or deliberate release.
- Identification and quantitation of organophosphate adducts with acetylcholinesterase, butyrylcholinesterase and albumin (D Vidler, M Dunn, FM Williams, PG Blain)
- Determination of the oxidative stress indicators, 8OHdG and isoprostanes, in urine, plasma and cell extracts (M Dunn, FM Williams, PG Blain)
- Identification and quantitation of ceramides and sphingolipids in relation to neurotoxicity (M Dunn, FM Williams, PG Blain)
- Use of GC and LC mass spectrometric techniques to monitor and quantify the dermal penetration/transportation of a range of pesticides and peptides (M Dunn, FM Williams, PG Blain)
- Aetiology of gastroschisis: A prospective case control study to investigate the effects of lifestyle, dietary and environmental exposures ( R Jefferson in collaboration with S Palmer, HPA)
- Quantifying health effects from exposure to soil contamination (R Jefferson in collaboration with Imperial College London)