Cellular pathology within the anterior cingulate cortex of patients with late-life depression: A morphometric study (2011)

Author(s): Khundakar AA, Morris CM, Oakley AE, Thomas AJ

    Abstract: Previous imaging and morphometric studies have identified volumetric and cellular abnormalities in prefrontal areas in late-life depression. This study aimed to examine cellular morphology using stereological methodology in the supragenual region of the anterior cingulate cortex in late-life depressed patients compared with age-matched controls. Post-mortem tissue was acquired from nine patients with depression and 11 control patients and analyzed using the optical disector and nucleator methods. No changes were found in glial, non-pyramidal and pyramidal cell density, or in non-pyramidal or pyramidal cell volume within individual layers (2-5) or the supragenual anterior cortex as a whole. This study, therefore, does not provide further evidence for cellular abnormalities in late-life depression.

      • Date: 30-11-2011
      • Journal: Psychiatry Research: Neuroimaging
      • Volume: 194
      • Issue: 2
      • Pages: 184-189
      • Publisher: Elsevier Ireland Ltd
      • Publication type: Article
      • Bibliographic status: Published

      Dr Christopher Morris
      Senior Lecturer