Self-Organisation of Self-Complementary DNA Molecules Covalently Attached to Silicon Surfaces (2011)

Author(s): Carlsson S, Gonzalez R, O'Farrell N, Patole SN, Connolly BA, Houlton A, Horrocks BR, Pike A

    Abstract: Self-complementary oligonucleotides were synthesized at atomically-flat Si(111) surfaces and their hybridization reaction was studied using atomic force microscopy. Annealing these surfaces in aqueous media, in the absence of any other reagents or DNA, resulted in a self-organization process in which hybridization produced well-defined features in the AFM images. By varying the surface coverage of DNA we provide evidence that the features observed are due to inter-strand rather than intra-strand hybridization reactions.

      • Date: 01-06-2011
      • Journal: Science of Advanced Materials
      • Volume: 3
      • Issue: 3
      • Pages: 483-489
      • Publisher: American Scientific Publishers
      • Publication type: Article
      • Bibliographic status: Published

      Dr Ben Horrocks
      Senior Lecturer

      Professor Andrew Houlton
      Professor of Inorganic Chemistry

      Dr Andrew Pike
      Senior Lecturer, Undergraduate Admissions Tutor