Our surgical trials portfolio includes head-to-head comparisons of different surgical techniques, as well as comparisons of surgical versus medical approaches to treatment. These trials are funded by NIHR and medical charities.
Clinical Trial of an Investigational Medicinal Product
A major part of our research portfolio is interventional drug trials, otherwise known as Clinical Trials of Investigational Medicinal Products (CTIMPs), from Phase I to Phase III. These are funded variously by industry, NIHR, research councils and medical charities.
They include both placebo-controlled trials, and head-to-head trials of two or more drugs. Also included in this category are trials of Advanced Therapy Medicinal Products (gene therapy medicinal products, somatic cell therapy products and tissue engineered products).
The MRC indicates that complex interventions are usually described as those that contain several interacting components, such as an educational or rehabilitation programme. However, MRC goes on to recognise that there “are, however, several dimensions of complexity: it may be to do with the range of possible outcomes, or their variability in the target population, rather than with the number of elements in the intervention package itself.”
The trials within our complex intervention portfolio include those of ‘packages of care’ (eg for rehabilitation) and those aimed at changing the behaviour of health professionals, patients and members of the public. They are funded by research councils (especially MRC) and NIHR.