Ageing research is a particular strength for Newcastle University, dating back to 1960s when academics in this area identified the major brain biochemical deficit which causes Alzheimer’s.
Since then, expertise has grown to cover multiple disciplines, covering ‘how we age’, ‘how we can age better’ and ‘how we can meet the meet the global challenge of ageing’.
Cancer research links to all three of these themes, for example:
- major advances in cellular and biological ageing and age-related diseases
- health interventions for healthier-disease free ageing
- examining the processes of ageing in those who experienced cancer at an earlier age
- Understanding the socio-economic impacts cancer on older people, or the impacts of cancer on different socio-economic groups
Finally, in an expanding ageing society, the importance of cross-cutting cancer and ageing research will grow, due to a larger portion of people living longer and being susceptible to certain cancers, more common in later life.
To discover more about the Institute of Ageing and what they do please visit their website.
Researchers and SpecialismsResearchers and Specialisms
Professor Mark Birch-Machin: Cutaneous response to ultraviolet radiation (UVR) in terms of skin ageing and cancer and the molecular genetics of skin cancer
Dr Matthew Breckons: effective and efficient care pathways for patients with chronic pain
Dr Morven Brown: improving the health of survivors of childhood, adolescent and young adult cancer
Dr Joanna Elson: application of population genetics and computational methods to the understanding of disease associated with Mitochondrial DNA (mtDNA) variation
Dr Laura Greaves: investigating the incidence and role of mitochondrial DNA point mutations during ageing of stem cell populations; functional consequences of these mutations on essential cellular functions, and the role they may have in the general tissue decline associated with the ageing process and malignant transformation
Emeritus Professor Tom Kirkwood: evolution and genetics of ageing, life of damage in cells and tissues, the principal genes determining longevity and rate of senescence
Dr Viktor Korolchuk: nutrient sensing; mTOR; autophagy; ageing
Dr Laura Maringele: cell division (eukaryote); cell sensing and signalling (eukaryote); cancer cell biology; the ageing cell
Professor John Mathers: molecular nutrition research; cancer-related studies; cardiovascular disease and diabetes-related studies; public health nutrition research; nutritional epidemiology; nutrition and ageing
Dr Manolis Papamichos Chronakis: genetic analysis, chromatin, genome stability, DNA damage
Dr Suzanne Moffatt: health, welfare and well-being among older people; impact of changes to the welfare state on older people, tackling health and social inequalities and applying research to policy and practice; the impact of a welfare rights service for people affected by cancer
Professor Vinidh Paleri: clinical trials in head and neck cancer
Dr Joao Passos: biology of ageing; the ageing cell; cell sensing and signalling
Professor Stephen Proctor: clinico-laboratory research in leukaemia in adults, clinical trials in leukaemia (adult) and malignant lymphoma, population study methodology in haematology and cancer, organisation of regional and supra-regional clinical and laboratory study groups in haematological oncology, (PACE - population adjusted clinical epidemiology group)
Professor Linda Sharp: cancer epidemiology; gastro-intestinal, prostate, cervical and head & neck cancers; cancer aetiology, through cancer screening, cancer treatment and treatment-decision making, to cancer survivorship
Dr Alberto Sanz Montero: the role of mitochondria in health and disease and especially how mitochondrial function is affected by ageing, strategies to preserve mitochondrial function during ageing in order to extend lifespan, different fly models to study ageing, age-related neurodegenerative disease (such as Parkinson’s disease) and primary mitochondrial disorders
Dr Gabriele Saretzki: the ageing cell; cell sensing and signalling (eukaryote), telomerase in ageing and cancer and under oxidative stress
Dr Daryl Shanley: mathematical models that examine ageing as an integral part of an optimal life history, understanding of the ageing process by building models with a solid mechanistic base
Professor Roderick Skinner: late adverse effects of treatment for childhood/adolescent malignancy and bone marrow transplantation (BMT), evidence-based guideline development for surveillance for late adverse effects, long-term follow-up of childhood/adolescent malignancy/BMT survivors
Professor Doug Turnbull: the role of mitochondrial DNA mutations in disease, the role of mitochondrial abnormalities in neurodegenerative disease, ageing and cancer
Dr Elizabeth Veal: exposure to sunlight, immune cell attack and aerobic metabolism generate highly toxic chemicals known as 'reactive oxygen species (ROS)’ and their implications in the development of many diseases, including cancer, heart disease and diabetes
Professor Thomas von Zglinicki: cell sensing and signalling (eukaryote); the ageing cell; cancer cell biology