Northern Institute for Cancer Research

Cancer Biology

Cancer Biology

The Institute of Cell and Molecular Biosciences (ICaMB) is a world-leading centre of excellence in UK Biosciences.

In the recent Research Excellence Framework (REF2014) evaluation of all UK universities, the ICaMB submission in the UOA5 unit of assessment was ranked second for Research Output (first among UK university departments) and 5th in the UK overall.

ICaMB possesses state of the art facilities that include recent investment in next generation DNA sequencing, bioinformatics, proteomics and cell imaging. Much of the research in ICaMB concerns fundamental cellular pathways that underpin our understanding of tumorigenesis.

These include the NF-kB pathway, cell cycle regulation and mitosis, the response of cells to anti-cancer therapies, DNA damage response, telomere biology and stress induced cell signalling pathways. Many components of these pathways are known to play key roles in cancer development and are either existing or future targets for therapy.