Northern Institute for Cancer Research

Staff Profile

Dr Alem Gabriel

Research Associate

Background

Qualifications

2011 - PhD Genetics, University of Kent

2006 - BSc. (Hons) Genetics, University of London

Previous Positions

2010-2011 - Research Assistant: University of Oxford

Memberships

BACR, EACR, SIOP, SIOPEN,


Honours and Awards

2016 - £450 travel grant to attend NCRI 2016, Liverpool

2016 - £450 travel grant from Newcastle University to attend SIOP 2016, Dublin

2015 - €500 travel grant from the European Hematology Association

2011 - Times Higher Education nominee for 'project of the year'

2011 - Young scientist prize winner: 18th meeting of the International Chromosome and Genome Society

2010 - First prize winner: 5th Annual symposium of Centre for Biomedical Informatics


Roles and Responsibilities

Training and supervision of undergraduate and postgraduate students

Member of Athena Swan Self- Assessment Team (SAT)

Research

Research Interests

Neuroblastoma

Despite advances in neuroblastoma therapy relapse still occurs in 50% of high risk cases and in most high risk cases cure is no longer possible. Recent studies report an increased frequency of recurrent, genetic abnormalities at relapse including segmental chromosomal abnormalities (SCA)  and gene mutations for which targeted treatments exist e.g. anaplastic lymphoma kinase gene (ALK)  and RAS-MAPK pathway mutations or is planned e.g. MDM2/p53 inhibitors for neuroblastoma lacking TP53 mutations . Identification of new genetic abnormalities at relapse is important to predict response to existing targeted agents e.g. ALK inhibitors, but moreover to identify potential new treatment targets. By studying paired tumours at diagnosis and relapse we are attempting to determine whether these genetic abnormalities are present in a sub-clone at diagnosis, at what frequency, and if so whether we should be considering upfront treatment with targeted therapies


Funding

Action Medical Research

Great Ormond Street Hospital Children's Charity



 

Teaching



Publications