Emeritus Professor Barbara DurkaczEmeritus Professor
Email: barbara.durkacz@ncl.ac.uk Telephone: +44 (0) 191 222 4413 Fax: +44 (0) 191 222 7556 Address: Northern Institute for Cancer Research
Veuger SJ, Curtin NJ, Smith G, Durkacz BW. Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair .
Oncogene 2004,23 44 7322-7329.
Hunter JE, Willmore E, Irving JAE, Hostomsky Z, Veuger SJ, Durkacz BW. NF-kappa B mediates radio-sensitization by the PARP-1 inhibitor, AG-014699 .
Oncogene 2012, 31 (2), 251-264.
Veuger SJ, Durkacz BW. Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-kappa B activation .
DNA Repair 2011, 10 (2), 235-244.
Willmore E, Skowronska A, Mulligan EA, Ahmed G, Elliott S, Summerfield GP, Hamlen K, Lowe C, Durkacz BW, Stankovic T. ATM Mutant Chronic Lymphocytic Leukaemia Cells are Chemosensitized by Inhibition of DNA Dependent Protein Kinase .
In: Blood: 52nd Annual Meeting of the American Society of Hematology . 2010, Orlando, Florida, USA: American Society of Hematology.
Mulligan EA, Hunter JE, Baird AEG, Elliott S, Summerfield GP, Hamlen K, Lowe C, Wallis J, Veuger S, Durkacz BW, Willmore E. Relationships Between Aberrant Activity of the NF-kappa B Subunits and Outcome In Chronic Lymphocytic Leukemia: The Dual Role of DNA Damage Sensor Enzymes .
In: Blood: 52nd Annual Meeting of the American Society of Hematology . 2010, Orlando, Florida, USA: American Society of Hematology.
Willmore, E., De Caux, S., Sunter, N., Tilby, M.J., Jackson, G., Austin, C., Durkacz, B.W. A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia .
Blood 2004, 103 (12), 4659-4665.
Calabrese C, Almassy R, Barton S, Batey M, Calvert AH, Canan-Koch S, Durkacz B, Hostomsky Z, Kumpf R, Kyle S, Li J, Maegley K, Newell DR, Notarianni E, Stratford I, Skalitzky D, Thomas HD, Wang L, Webber S, William K, Curtin NJ. Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361 .
Journal of the National Cancer Institute 2004, 96 (1), 56-67.
Calabrese C, Batey M, Thomas HD, Durkacz B, Wang L, Kyle S, Skalitzky D, Li J, Zhang C, Boritzki T, Maegley K, Calvert AH, Hostomsky Z, Newell DR, Curtin NJ. Identification of potent nontoxic poly(ADP-ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies .
Clinical Cancer Research 2003, 9 (7), 2711-2718.
Veuger, S., Curtin, N.J., Richardson, C., Smith, G., Durkacz, B.W. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1 .
Cancer Research 2003, 63 (18), 6008-6015.
Delaney, C.A., Wang, L., Kyle, S., White, A.W., Calvert, A.H., Curtin, N.J., Durkacz, B.W., Hostomsky, Z, Newell, D.R. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines .
Clinical Cancer Research 2000, 6 (7), 2860-2867.
Boulton SJ, Kyle S, Durkacz BW. Cytotoxic mechanism of the protein kinase inhibitor wortmannin in ionising radiation and etoposide treated cells .
British Journal of Cancer 1999, 80 (supplement 2), 44 P64.
Boulton, S., Kyle, S, Durkacz, B.W. Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage .
Carcinogenesis 1999, 20 (2), 199-203.
Boulton, S., Kyle, S., Durkacz, B.W. Low nicotinamide mononucleotide adenylyltransferase activity in a tiazofurin-resistant cell line: Effects on NAD metabolism and DNA repair .
British Journal of Cancer 1997, 76 (7), 845-851.
Boulton, S., Kyle, S., Yalçintepe, L., Durkacz, B.W. Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells .
Carcinogenesis 1996, 17 (11), 2285-2290.
