Newcastle University

Qualifications

MSc Organic Chemistry - Poitiers, France
PhD Organic Chemistry - Poitiers, France

Previous Positions

2005 - Research associate in the group of Professor John A. Joule - The University of Manchester, UK - "Synthesis of Analogues of Cofactors of Oxomolybdoenzymes".

2005-2007 - Research Associate - Northern Institute for Cancer Research, Newcastle Upon Tyne, UK - "Synthesis of Inhibitors of DNA-Dependent Protein Kinase".

Research Interests

My main area of research is the development of potent and specific molecule inhibitors of DNA-dependent protein kinase (DNA-PK).

Undergraduate Teaching

- Laboratory supervision: CHY3001 Practical Course in Medicinal Chemistry
- Lectures CHY2103: Medicinal Chemistry and Drug Design (Module Leader)
- Lectures CHY8421 and CHY8821: Advanced Methods in Drug Discovery
- PARTNERS Assessed Summer School

• Tavecchio M, Munck JM, Cano C, Newell DR, Curtin NJ. Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination. Cancer Chemotherapy and Pharmacology 2011, (epub ahead of print).
• Rodriguez SA, Clapham KM, Barrett L, Cano C, Desage ME, Griffin RJ, Hardcastle IR, Payne SL, Rennison T, Richardson C, Golding BT. Versatile Synthesis of Functionalised Dibenzothiophenes via Suzuki Coupling and Microwave-assisted Ring Closure. Organic & Biomolecular Chemistry 2011, 9(17), 6066-6074.
• Rodriguez-Aristegui S, Clapham KM, Barrett L, Cano C, Desage-El Murr M, Griffin RJ, Hardcastle IR, Payne SL, Rennison T, Richardson C, Golding BT. Versatile synthesis of functionalised dibenzothiophenes via Suzuki coupling and microwave-assisted ring closure. Organic & Biomolecular Chemistry 2011, 9(17), 6066-6074.
• Clapham KM, Bardos J, Finlay R, Golding BT, Griffen EJ, Griffin RJ, Hardcastle IR, Menear KA, Ting A, Turner P, Young GL, Cano C. DNA-dependent protein kinase (DNA-PK) inhibitors: Structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain. Bioorganic & Medicinal Chemistry Letters 2011, 21(3), 966-970.
• Clapham KM, Rennison T, Rodriguez-Aristegui S, Bardos J, Curtin NJ, Golding BT, Hardcastle IR, Newell DR, Cano C, Griffin RJ. Development of potent inhibitors of DNA-dependent protein kinase (DNA-PK). In: EJC Supplements: 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2010, Berlin, Germany: Pergamon.
• Carbain B, Roche C, Endicott JA, Golding BT, Hardcastle IR, Cano C, Zhen-Wang L, Newell DR, Noble MEM, Griffin RJ. Structure-based design of C8-substituted O6-alkylguanine CDK1 and 2 inhibitors. In: European Journal of Cancer Supplements: 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2010, Berlin: Elsevier.
• Cano C, Barbeau OR, Bailey C, Cockroft XL, Curtin NJ, Duggan H, Frigerio M, Golding B, Griffin RJ. DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype. Journal of Medicinal Chemistry 2010,53 24 8498–8507.
• Payne SL, Rodriguez-Aristegui S, Bardos J, Cano C, Golding BT, Hardcastle IR, Peacock M, Parveen N, Griffin RJ. Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors. Bioorganic & Medicinal Chemistry Letters 2010, 20(12), 3649-3653.
• Cano C, Golding BT, Haggerty K, Hardcastle IR, Peacock M, Griffin RJ. Atropisomeric 8-arylchromen-4-ones exhibit enantioselective inhibition of the DNA-dependent protein kinase (DNA-PK). Organic & Biomolecular Chemistry 2010, 8(8), 1922-1928.
• Marchetti F, Cano C, Curtin NJ, Golding BT, Griffin RJ, Haggerty K, Newell DR, Parsons RJ, Payne SL, Wang LZ, Hardcastle IR. Synthesis and biological evaluation of 5-substituted O-4-alkylpyrimidines as CDK2 inhibitors. Organic & Biomolecular Chemistry 2010, 8(10), 2397-2407.
• Murr M, Cano C, Golding BT, Hardcastle IR, Hummersome M, Frigerio M, Curtin NJ, Menear K, Richardson C, Smith G, Griffin R. 8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK). Bioorganic and Medicinal Chemistry Letters 2008, 18(17), 4885-4890.
• Cano C, Curtin NJ, Golding BT, Haggerty K, Hardcastle IR, Hummersone M, Menear K, Richardson C, Smith GCM, Griffin RJ. Development of Potent Water-soluble Inhibitors of DNA-Dependent Protein Kinase (DNA-PK). In: 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics.2008,Geneva, Switzerland:European Journal of Cancer Supplements: Pergamon
• Willmore E, Elliott SL, Mainou-Fowler T, Summerfield GP, Jackson GH, O'Neill F, Lowe C, Carter A, Harris R, Pettitt AR, Cano-Soumillac C, Griffin RJ, Cowell IG, Austin CA, Durkacz BW. DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia. Clinical Cancer Research 2008,14 12 3984-3992.
• Cano-Soumillac C. Five-membered rings with two adjacent heteroatoms with at least one other element. In:Katritzky AR; Ramsden CA; Scriven EFV; Taylor RJK; Joule J ed .Comprehensive Heterocyclic Chemistry III, A review of the literature 1995-20072008. Oxford:Elsevier,4/15 1243-1270.
• Cano C. Five-membered rings with two non-adjacent heteroatoms with at least one other element. In:Katritzky, A.R. ed .Comprehensive Heterocyclic Chemistry III: A Review of the Literature 1995-20072008. Amsterdam:Elsevier,4/15 1271-1304.
• Saravanan K, Albertella M, Cano C, Curtin NJ, Frigerio M, Golding BT, Haggerty K, Hardcastle IR, Hummersone M, Menear K, Newell DR, Rennison T, Richardson C, Rigoreau L, Rodriguez-Aristegui S, Smith GCM, Griffin RJ. Identification of potent water-soluble DNA-dependent protein kinase (DNA-PK) inhibitors using a small-molecule library approach [abstract]. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research.2008,San Diego, CA:AACR
• Hollick J, Rigoreau L, Cano-Soumillac C, Cockcroft X, Curtin NJ, Frigerio M, Golding BT, Guiard S, Hardcastle IR, Hickson I, Hummersone M, Menear K, Martin N, Matthews I, Newell DR, Ord R, Richardson C, Smith G, Griffin RJ. Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase. Journal of Medicinal Chemistry 2007,50 8 1958-1972.
• Barbeau OR, Cano-Soumillac C, Griffin RJ, Hardcastle IR, Smith GCM, Richardson C, Clegg W, Harrington RW, Golding BT. Quinolinone and pyridopyrimidinone inhibitors of DNA-dependent protein kinase. Organic & Biomolecular Chemistry 2007, 5(16), 2670-2677.
• Alphonse F-A, Karim R, Cano-Soumillac C, Hebray M, Collison D, Garner CD, Joule JA. A bis(η5-cyclopentadienyl)cobalt complex of a bis-dithiolene: a chemical analogue of the metal centres of the DMSO reductase family of molybdenum and tungsten enzymes, in particular ferredoxin aldehyde oxidoreductase. Tetrahedron 2005, 61(46), 11010-11019.
• Bashiardes G, Cano C, Mauzé B. Regio- and Enantioselective Synthesis of Novel Functionalized Pyranopyrrolidines by 1,3-Dipolar Cycloaddition of Carbohydrates. Synlett 2005,4 587-590.
• Bashiardes G, Cano C, Mauzé B. Stereoselective Cycloaddition on Carbohydrates for the Synthesis of New Bicyclic Oxazolidines Bearing a Quaternary Bridgehead. Synlett 2005, (9), 1425-1428.