Dr Deepali Pal
NC3Rs Training Fellow
- Email: email@example.com
- Address: Wolfson Childhood Cancer Research Centre
Northern Institute for Cancer Research
Herschel Building, Level 6
Newcastle upon Tyne
NE1 7RU, UK
M.B.B.S. (First Class), Kasturba Medical College, Manipal University - 2008
MSc (Medical Genetics), International Centre for Life, Newcastle University - 2009
PhD (Cancer and Stem Cell Research): 2010-2014
NICR Teaching and Training Committee Postgraduate representative, Newcastle University: September 2010 - January 2012
Graduate School Committee Representative , Medical School, Newcastle University: 2011
Awards, Esteem Indicators:
1. RCUK NC3RS Training Fellowship, 2017
2. Invited to write a preview : Pal, D., Heidenreich, O., Vormoor, J. Dormancy stems the tide of chemotherapy. Cancer Cell, November 2016.
3. JGW Patterson Foundation Fellowship, 2015
4. MARIE CURIE Fellowship as part of the EU-funded project Prostate Research Organizations-Network of Early Stage Training (PRO-NEST), 2010
5. Presented with the ARTP award for the best paper (oral paper) in Prostate Cancer Research at the 20th Meeting of the European Association of Urology Section of Urological Research, October 2013.
6. Presented with the NCRI Prize award 2012 as an invited speaker for abstract - Induced pluripotent stem cell (iPSC) reprogramming of the elderly human prostate into a primitive embryonic stem cell state - a model for prostatic development and carcinogenesis.
7. Presented with Travel award to give an oral presentation at the 20th Meeting of the EAU Section of Urological Research, 25-27 October 2012, Strasbourg. Abstract: Induced pluripotent stem cell reprogramming of the elderly human prostate
8. Presented with a Travel award to present a poster at the 9th World congress on Urological Research, 2011. Abstract: " The role of EMT in iPS induction of human prostate"
9. Presented with a Travel Bursary to attend and give oral presentations at the Academic Urology section of the Annual SARS (Society of Academic and Research Surgery) meeting, 2012.
Leukaemia research, bone marrow niche
Induced pluripotent stem cell technology
Bioprinting, non-animal technology, drug combination studies
Self-renewal genes and pathways in Lymphoid malignancies
The role of epithelial to mesenchymal transition (EMT) in de-differentiation and carcinogenesis
Current lab members:
Ryan Nelson, Research technician
TeachingSupervision of Masters and PhD students and junior staff
- Heer R, Glendinning RJ, Nesbitt CN, Pal D, Rix D, Menezes P, Johnson MI. Secondary haemorrhage following transurethral resection of bladder tumour — is it always related to infection?. British Journal of Medical and Surgical Urology 2012, 5(2), 61-66.
- Pal D, Williamson SC, Robson CN, Rigas AC, Heer R. Characterising potential for pluripotency induction in human prostate tissue. In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgery. 2011, Dublin, Ireland: John Wiley & Sons Ltd.
- Pal D, Robson CN, Williamson SC, Nayernia K, Soleimanpour-Lichaei HR, Heer R. Stem-cell regulatory protein Piwil2 enriches for known stem-cell and cancer stem-cell markers in prostate cancer cells. In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgery. 2011, Dublin, Ireland: John Wiley & Sons Ltd.
- Pal D, Rigas AC, Williamson SC, Moad M, Carr-Wilkinson J, Lako L, Robson CN, Heer R. Induced pluripotent stem cell (iPSC) re-programming in the human prostate. In: Annual Meeting of the Society of Academic and Research Surgery. 2012, Nottingham, UK: John Wiley & Sons Ltd.
- Pal D, Rigas AC, Williamson SC, Moad M, Robson CN, Heer R. The role of epithelial to mesenchymal transition (EMT) in iPS induction of human prostate. In: Annual Meeting of the Society of Academic and Research Surgery. 2012, Nottingham, UK: John Wiley & Sons Ltd.
- Williamson SC, Hepburn AC, Wilson L, Coffey K, Ryan-Munden CA, Pal D, Leung HY, Robson CN, Heer R. Human α2β1HI CD133+VE Epithelial Prostate Stem Cells Express Low Levels of Active Androgen Receptor. PLoS One 2012, 7(11), e48944.
- Moad M, Pal D, Hepburn AC, Williamson SC, Wilson L, Lako M, Armstrong L, Hayward SW, Franco O, Cates J, Fordham SE, Przyborski S, Carr-Wilkinson J, Robson CN, Heer R. A novel model of urinary tract differentiation, tissue regeneration, and disease: Reprogramming human prostate and bladder cells into induced pluripotent stem cells. European Urology 2013, 64(5), 753-761.
- Singhapol C, Pal D, Czapiewski R, Porika M, Nelson G, Saretzki GC. Mitochondrial Telomerase Protects Cancer Cells from Nuclear DNA Damage and Apoptosis. PLoS One 2013, 8(1), e52989.
- Townes CL, Ali A, Gross N, Pal D, Williamson SC, Heer R, Robson CN, Pickard R, Hall J. Prostate specific antigen enhances the innate defence of prostatic epithelium against Escherichia coli infection. The Prostate 2013, 73(14), 1529-1537.
- Pal D, Moad M, Hepburn AC, Williamson SC, Robson CN, Heer R. Reply from Authors re: "Reprogramming Stromal Cell from the Urinary Tract and Prostate: A Trip to Pluripotency and Back?". European Urology 2013. In Press.
- Moad M, Hepburn A, Lako M, Pal D, Williamson S, Robson C, Heer R. Generation of induced pluripotent stem cells from human urinary tract cells. In: Annual Meeting of the Society of Academic and Research Surgery. 2013, London, UK: John Wiley & Sons Ltd.
- Hepburn AC, Gaughan L, Williamson SC, Pal D, Moad M, Kanani MK, Robson CN, Heer R. Investigating the regulation and effects on androgen receptor expression using a novel stem cell environment model of castration resistant prostate cancer. In: Annual Meeting of the Society of Academic and Research Surgery. 2013, London, UK: Wiley-Blackwell.
- Pal D, Moad M, Hepburn AC, Williamson SC, Robson CN, Heer R. Reply from Authors re: Felix Wezel, Jennifer Southgate. Reprogramming Stromal Cells from the Urinary Tract and Prostate: A Trip to Pluripotency and Back? Eur Urol 2013;64:762-4. European Urology 2013, 64(5), 764-765.
- Ponthan F, Bomken S, Pal D, Elder A, McNeill H, Vormoor J, Heidenreich O. A Genome-Wide RNAi Screen to Identify Novel Genes Involved in Clonal Maintenance of ALL. In: 56th ASH Annual Meeting. 2014, San Francisco, CA, USA: American Society of Hematology.
- Weiland J, Pal D, Case M, Irving J, Ponthan F, Koschmieder S, Heidenreich O, vonStackelberg A, Eckert C, Vormoor J, Elder A. BCP-ALL blasts are not dependent on CD19 expression for leukaemic maintenance. Leukemia 2016, 30(9), 1920–1923.
- Pal D, Heidenreich O, Vormoor J. Dormancy Stems the Tide of Chemotherapy. Cancer Cell 2016, 30(6), 825-826.
- Pal D, Blair HJ, Elder A, Dormon K, Rennie KJ, Coleman DJL, Weiland J, Rankin KS, Filby A, Heidenreich O, Vormoor J. Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia. Leukemia 2016, epub ahead of print.
- Dormon K, Latif ES, Bashton M, Pal D, Selby M, Blair H, Rand V, Hall AG, Vormoor J, Heidenreich O. A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse. In: ASH 2015 Annual Meeting. 2015, Orlando, USA: American Society of Hematology.
- Elder A, Bomken S, Wilson I, Blair HJ, Cockell S, Ponthan F, Dormon K, Pal D, Heidenreich O, Vormoor J. Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia. Leukemia 2017, ePub ahead of print.
- Ribeiro R, Pal D, Jamieson D, Rankin K, Benning M, Dalgarno K, Ferreira A. Temporary Single Cell Coating for Bioprocessing via a Cationic Polymer. ACS Applied Materials & Interfaces 2017, 9(15), 12967-12974.