Dr Ian Hardcastle
Senior Lecturer in Medicinal Chemistry
- Email: i.r.hardcastle@ncl.ac.uk
- Telephone: 0191 222 6645
- Address: Northern Institute for Cancer Research
ADDI Laboratories
School of Chemistry
Bedson Building
Newcastle University
Newcastle upon Tyne
NE1 7RU
Selected Publications
- Seeberger S; Griffin RJ; Hardcastle IR; Golding BT. A new strategy for the synthesis of taurine derivatives using the 'safety-catch' principle for the protection of sulfonic acids. Organic & Biomolecular Chemistry 2007, 5(1), 132-138.
- Aristegui SR; El-Murr MD; Golding BT; Griffin RJ; Hardcastle IR. Judicious application of allyl protecting groups for the synthesis of 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl triflate, a key precursor of DNA-dependent protein kinase inhibitors. Organic Letters 2006, 8(26), 5927-5929.
- Griffin, R.J.; Henderson, A.; Curtin, N.J.; Echalier, A.; Endicott, J.; Hardcastle, I.R.; Newell, D.R.; Noble, M.; Wang, L.; Golding, B.T. Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination. Journal of the American Chemical Society 2006, 128(18), 6012-6013.
- Hardcastle, I.R.; Ahmed, S.; Atkins, H.; Farnie, G.; Golding, B.T.; Griffin, R.J.; Guyenne, S.; Hutton,C.; Källblad, P.; Kemp, S.; Kitching, M.S.; Newell, D.R.; Norbedo, S.; Northen, J.S.; Reid, R.J.; Saravanan, K.; Willems, H.; Lunec, J. Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold. Journal of Medicinal Chemistry 2006, 49(21), 6209-6221.
- Walton MI; Wilson SC; Hardcastle IR; Mirza AR; Workman P. An evaluation of the ability of pifithrin-alpha and -beta to inhibit p53 function in two wild-type p53 human tumor cell lines. Molecular Cancer Therapeutics 2005, 4(9), 1369-1377.
- Hardcastle, I.; Cockcroft, X; Curtin, N.J.; El-Murr, M.; Leahy, J.J.J.; Stockley, M.; Golding, B.T.; Rigoreau, L.; Richardson, C.; Smith, G.; Griffin, R.J. Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. Journal of Medicinal Chemistry 2005, 48(24), 7829-7846.
Qualifications
BSc (Hons) Chemistry - Bristol
MSc Organic Chemistry - Manchester
PhD Organic Chemistry - Manchester
Previous Positions
Non-clinical Research Fellow CRC Centre for Cancer Therapuetics at the Institute of Cancer Research (Sutton) UK
Memberships
Member of the Royal Society of Chemistry
Member of the American Chemical Society
Member of the American Association for Cancer Research
