Newcastle University

Roles and Responsibilities

NICR Safety committee, safety equipment in NICR
NICR Tissue Culture committee

Qualifications

B.Sc., Biochemistry, University of Birmingham
Ph.D., Faculty of Medicine, University of Newcastle

Memberships

Member of British Association for Cancer Research (BACR), and American Association for Cancer Research (AACR)

Research Interests

Matrix metalloproteinases
Growth Factor Receptors and their inhibitors
Bladder cancer
Mesothelioma

Research Roles

Supervision of postgraduate students with projects on folate receptors in breast and ovarian cancer, and the use of pemetrexed in mesothelioma

Esteem Indicators

Poster presentations at NCRI meeting, Birmingham Oct 2005 and AACR 2004
Peer review of manuscripts for European Urology

• Razak AA, Nutt J, O'Toole K, Black F, Cole M, Plummer R, Lunec J, Calvert H. Expression of methylthioadenosine phosphorylase (MTAP) in malignant pleural mesothelioma (MPM) and its implication for pemetrexed-based chemotherapy. In: EJC Supplements: 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2010, Berlin, Germany: Pergamon.
• Nutt, J., Lazarowicz, H., Mellon, J., Lunec, J. Gefitinib ('Iressa', ZD1839) inhibits the growth response of bladder tumour cell lines to epidermal growth factor and induces TIMP2. British Journal of Cancer 2004, 90(8), 1679-1685.
• Durkan, G., Nutt, J., Marsh, C., Rajjayabun, P., Robinson,M., Neal, D.E., Lunec, J., Mellon, J.K. Alteration in urinary matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio predicts recurrence in nonmuscle-invasive bladder cancer. Clinical Cancer Research 2003, 9(7), 2576-2582.
• Durkan, G.C., Nutt, J.E., Rajjayabun, P.H., Neal, D.E., Lunec, J., Mellon, J.K. Prognostic significance of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in voided urine samples from patients with transitional cell carcinoma of the bladder. Clinical Cancer Research 2001, 7(11), 3450-3456.
• Nutt, J.E., Durkan, G., Mellon, K., Lunec, J. Matrixmetalloproteinase stimulation in bladder tumour cell lines and elevated levels in the urine of bladder tumour patients.. British Journal of Cancer 1999, 80(Supplement 1), 37-37.
• Nutt, J., Mellon, J., Qureshi, K., Lunec, J. Matrix metalloproteinase-1 is induced by epidermal growth factor in human bladder tumour cell lines and is detectable in urine of patients with bladder tumours. British Journal of Cancer 1998, 78(2), 215-220.
• Nutt J, Lunec J. Induction of metalloproteinase (MMP1) expression by epidermal growth factor (EGF) receptor stimulation and serum deprivation in human breast tumour cells. European Journal of Cancer Part A 1996, 32(12), 2127-2135.