Northern Institute for Cancer Research

Staff Profile

Dr Janet Lindsey

Research Associate

Background

Background

Research associate

Qualifications

BSc.(1st class hons)in Genetics Newcastle University 1984
PhD University of Edinburgh 1987

Previous Positions

Senior postdoctoral research associate Northern Institute for cancer research 2005-2013

Postdoctoral research associate Northern Institute for cancer research 2001-2005

Postdoctoral research associate,Department of Dermatology, University of Newcastle upon Tyne 2000-2001
Postdoctoral research associate,Department of Human Genetics, University of Newcastle upon Tyne 1998-2000
Self-employed working for the Royal College of Surgeons of Edinburgh, setting up an on-line version of the Journal of the Royal College of Surgeons of Edinburgh. 1997-2001
Postdoctoral research associate,Department of Human Genetics, University of Newcastle upon Tyne 1991-1992
Postdoctoral research associate,MRC Human Genetics Unit, Edinburgh 1988-1990
Postdoctoral research associate,Department of Molecular Biology, University of Edinburgh 1987-1988

Memberships

BACR

Research

Research Interests

My research is on the molecular basis of medulloblastoma. My particular interests include

1. Epigenetic changes in medulloblastoma. Genome wide studies (epigenomics) to determine cancer specific methylation changes in medulloblastoma and investigation of their use as prognostic biomarkers and potential as therapeutic targets of the disease.  I am interested in determining the conservation of these events in human cell line models and mouse models of the disease (cross species epigenomics); allowing investigation of the functional relevance of these changes (functional investigations in mouse and human cell lines performed at Newcastle University, modelling in genetically engineered mouse models performed in collaboration with other groups).

2. Biological mechanisms of disease relapse.  Investigation of the genetic and epigenetic changes of medulloblastoma samples taken at relapse compared to diagnostic samples.

3. Investigating and targeting MYC and MYC(N) gene amplification. The transcriptomic, proteomic and epigenomic changes induced by MYC(N) overexpression. Assessment of potential new therapeutic strategies for MYC(N) amplified tumours.

Funding

I am currently funded as part of the INSTINCT program (High risk childhood brain tumour network) by The Brain Tumour Charity

Teaching

Devising, supervising and marking undergraduate and masters projects.

Laboratory supervision of PhD students.



Publications