Northern Institute for Cancer Research

Staff Profile

Dr Matthew Bashton

Research Associate

Background

I currently work in the area of Leukaemia genomics and bioinformatics at the Northern Institute of Cancer Research (NICR) in the Leukaemia Research Cytogenetics Groupon (LRGC).  Prior to this I worked on the INSTINCT project analysing various -omics data types on childhood brain tumours also at the NICR. 

Previously I worked as a core Bioinformatician in the Bioinformatics Support Unit (BSU) analysing many diverse types of data.  Specifically microarrays: expression, tiling, and methylation; hight-throughput sequencing data: RNA-Seq, exome and WGS variant calling, bi-sulphite, metagenomics and targeted panels. 

Whilst in Cambridge my research was in the area of structural bioinformatics, specifically how protein domains combine to generate novel functions.  I also worked in the area of protein ligand interactions and chemoinformatics.  I was a postdoc at the EBI in the group of Janet Thornton and I was a PhD student at the MRC Laboratory of Molecular Biology in the group of Cyrus Chothia.

Qualifications

B.Sc. (Hons) - Biochemistry - Newcastle University, 2000

Ph.D. - Bioinformatics - Cambridge University, 2004

Roles

Lecture on various bioinformatics topics at undergraduate and masters level for the Schools of Biomedical Sciences and Computer Science

Member of Centre for Health and Bioinformatics (CHaBi)

Personal Tutor

Professional Memberships

International Society for Computational Biology: ISCB

Research

Research Interests

Leukaemia genomics and bioinformatics

My main areas of research prior to Newcastle have been:

  •  Chemoinformatics: SMSD
  •   Pfam (author of over 270 Pfam domains)
 

Teaching

I currently teach on:

CMB2000: Principles & Practice of Molecular Techniques, lecture on Microarrays

BMS3025: Bioinformatics, lecture on variant calling in genomes and exomes

CSC8309: High Throughput Technologies, lecture on variant calling in genomes and exomes

I have previously taught on:

CSC8313: Bioinformatics Theory and Practice, 2 lectures on Microarrays


Publications