Dr Simon Bomken
Academic Clinical Lecturer

  • Email: s.n.bomken@ncl.ac.uk
  • Telephone: +44 (0) 191 208 4300
  • Fax: +44 (0) 191 208 4301
  • Address: Northern Institute for Cancer Research
    Paul O'Gorman Building
    Medical School
    Framlington Place
    Newcastle upon Tyne
    NE2 4HH

Qualifications

2013 PhD, Newcastle University

2005 Membership of the Royal College of Paediatrics and Child Health, UK

2002 MBBS (Hons), Newcastle University

1999 BMedSci (Hons), Newcastle University 

Memberships

Academic Paediatric Association GBI
British Association for Cancer Research
Children's Cancer & Leukaemia Group (CCLG)
Paediatric Oncology Trainees Group (CCLG)

Honours and Awards

Mona McNaughton Prize - MBBS (Hons) final examination results 2002
Wolfson Scholar - BMedSci (Hons) 1998/9

Research Interests

Aggressive B cell lymphoma of childhood (focusing on Burkitt lymphoma and post-transplantation lymphoproliferative disorders (PTLD)) - development of functional genomic screens and pre-clinical modelling

Childhood acute lymphoblastic leukaemia - characterisation of cancer propagating cells

Langerhans Cell Histiocytosis - Paediatric clinical service associated with Newcastle Human Dendritic Cell Laboratory (http://www.hudendritic.org/

Current Work

We are currently developing improved pre-clinical models for the validation of novel therapeutic targets for Burkitt lymphoma and testing of new precision medicines designed to improve rates of cure whilst reducing the extensive toxicity associated with current treatments for aggressive B cell lymphoma.

I continue to be closely involved with projects aimed at understanding the genomic drivers of malignant B cell self-renewal.  This work takes both a candidate approach and an unbiased, genome-wide approach to identify important elements of the genetic programmes allowing malignant cells to self-renew and propagate a malignancy.  As lymphoid cells have an inherent potential for clonal expansion, this work looks to identify elements of the clonal expansion programme of lymphoid cells which are harnessed in lymphoid malignancy.  It is therefore thought to be applicable to both B precursor and mature B cell diseases.

Funding - Current Projects 

Children with Cancer UK

Academy of Medical Sciences

Funding - Training

ACL post funded by NIHR

MRC Centenary Early Career Award

MRC Clinical Research Training Fellowship

ACF post funded by National Institute for Health Research (NIHR)