2015 CCT Paediatrics (Paediatric Oncology)
2013 PhD, Newcastle University
2005 Membership of the Royal College of Paediatrics and Child Health, UK
2002 MBBS (Hons), Newcastle University
1999 BMedSci (Hons), Newcastle University
Academic Paediatric Association GBI
British Association for Cancer Research
Children's Cancer & Leukaemia Group (CCLG)
2014 Lindau Nobel Laureate meeting alumnus, Royal Society nominee
2002 Mona McNaughton Prize - MBBS (Hons) final examination results 2002
1998 Wolfson Scholar - BMedSci (Hons)
Aggressive B cell lymphoma of childhood (focusing on Burkitt lymphoma and post-transplantation lymphoproliferative disorders (PTLD)) - development of functional genomic screens and pre-clinical modelling
Childhood acute lymphoblastic leukaemia - characterisation of cancer propagating cells
Langerhans Cell Histiocytosis - Paediatric clinical service associated with Newcastle Human Dendritic Cell Laboratory (http://www.hudendritic.org/)
We are currently developing improved pre-clinical models for the validation of novel therapeutic targets for Burkitt lymphoma and testing of new precision medicines designed to improve rates of cure whilst reducing the extensive toxicity associated with current treatments for aggressive B cell lymphoma.
I continue to be closely involved with projects aimed at understanding the genomic drivers of malignant B cell self-renewal. This work takes both a candidate approach and an unbiased, genome-wide approach to identify important elements of the genetic programmes allowing malignant cells to self-renew and propagate a malignancy. As lymphoid cells have an inherent potential for clonal expansion, this work looks to identify elements of the clonal expansion programme of lymphoid cells which are harnessed in lymphoid malignancy. It is therefore thought to be applicable to both B precursor and mature B cell diseases.
Academy of Medical Sciences
Newcastle Healthcare Charity
The Good Will Cause
ACL post funded by NIHR
MRC Centenary Early Career Award
MRC Clinical Research Training Fellowship
ACF post funded by National Institute for Health Research (NIHR)
I am actively involved in supervising undergraduate, masters and PhD students within the Northern Institute for Cancer Research, as well as providing clinical teaching for medical students within the Great North Children's Hospital.
I have contributed a chapter on clinical research to the recently published MRCPCH Mastercourse book for candidates of the Royal College of Paediatrics and Child Health membership exam. I am also currently re-writing chapters on childhood lymphoma and tumour lysis syndrome for the Oxford University Handbook of Paediatric Haematology and Oncology.