Newcastle University

Roles and responsibilities.

Consultant in Paediatric Oncology, Great North Childrens Hospital

Honorary Professor of Paediatric Neuro-Oncology, University of Newcastle upon Tyne. 

Qualifications. 

MBChB - University of Cape Town

MRCP (Paediatrics)

PhD

FRCPCH

Research Interests.

Molecular Diagnostics for improved treatment individualisation in childhood brain tumours patients.

Diffuse intrinsic pontine gliomas.

Development of treatment protocols for the resource challenged world. 

 Funding.

Action Medical Research

Cancer Research UK (CR-UK) 

JGW Patterson Foundation (JGWP)

Newcastle Hospitals Healthcare Charity

Samantha Dickson Brain Tumour Trust (SDBTT)

Sport Aiding Medical Research for Kids (SPARKS) 

Tropical Health and Education Trust (THET) 

• Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S. Burkitt's lymphoma. Lancet 2012, 379(9822), 1234-1244.
• Ryan SL, Schwalbe EC, Cole M, Lu Y, Lusher ME, Megahed H, O'Toole K, Nicholson SL, Bognar L, Garami M, Hauser P, Korshunov A, Pfister SM, Williamson D, Taylor RE, Ellison DW, Bailey S, Clifford SC. MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma. Acta Neuropathologica 2012, 123(4), 501-513.
• Bailey S, Skinner R, Carey P, Moorman A, Banda K, Banda F, Eden OB, Israels T, Molyneux E. Acute lymphoblastic leukarmia (ALL) in Malawi, progress in the first Malawi ALL protocol. In: Pediatric Blood & Cancer: 43rd Congress of the International Society of Paediatric Oncology (SIOP). 2011, Auckland, New Zealand: John Wiley & Sons, Inc.
• Ellison DW, Dalton J, Kocak M, Nicholson SL, Fraga C, Neale G, Kenney AM, Brat DJ, Perry A, Yong WH, Taylor RE, Bailey S, Clifford SC, Gilbertson RJ. Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups. Acta Neuropathologica 2011, 121(3), 381-396.
• Schwalbe EC, Lindsey JC, Straughton D, Hogg TL, Cole M, Megahed H, Ryan SL, Lusher ME, Taylor MD, Gilbertson RJ, Ellison DW, Bailey S, Clifford SC. Rapid Diagnosis of Medulloblastoma Molecular Subgroups. Clinical Cancer Research 2011, 17(7), 1883-1894.
• Lindsey JC, Hill RM, Megahed H, Lusher ME, Schwalbe EC, Cole M, Hogg TL, Gilbertson RJ, Ellison DW, Bailey S, Clifford SC. TP53 Mutations in Favorable-Risk Wnt/Wingless-Subtype Medulloblastomas. Journal of Clinical Oncology 2011, 29(12), E344-E346.
• Sinha A, Avery P, Turner S, Bailey S, Cheetham T. Vitamin D Status in Paediatric Patients With Cancer. Pediatric Blood & Cancer 2011, 57(4), 594-598.
• Ellison DW, Kocak M, Dalton J, Megahed H, Lusher ME, Ryan SL, Zhao W, Nicholson SL, Taylor RE, Bailey S, Clifford SC. Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables. Journal of Clinical Oncology 2010, (epub ahead of print).
• Tatevossian RG, Tang B, Dalton J, Forshew T, Lawson AR, Ma J, Neale G, Shurtleff SA, Bailey S, Gajjar A, Baker SJ, Sheer D, Ellison DW. MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas. Acta Neuropathologica 2010, 120(6), 679-683.
• Sulong S, Moorman AV, Irving JAE, Strefford JC, Konn ZJ, Case MC, Minto L, Barber KE, Parker H, Wright SL, Stewart ARM, Bailey S, Bown NP, Hall AG, Harrison CJ. A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups. Blood 2009, 113(1), 100-107.
• Forshew T, Tatevossian RG, Lawson AR, Ma J, Neale G, Ogunkolade BW, Jones TA, Aarum J, Dalton J, Bailey S, Chaplin T, Carter RL, Gajjar A, Broniscer A, Young BD, Ellison DW, Sheer D. Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas. Journal of Pathology 2009, 218(2), 172-181.
• Ellison D, Forshew T, Tatevossian R, Ma J, Neale G, Ogunkolade W, Dalton J, Bailey S, Chaplin T, Gajjar A, Sheer D. Activation of the MAPK Pathway: A Signature Genetic Defect in Posterior Fossa Pilocytic Astrocytomas. In: Journal of Neuropathology and Experimental Neurology: 85th Annual Meeting of the American Association of Neuropathologists. 2009, San Antonio, Texas, USA: Lippincott Williams & Wilkins.
• Lu Y, Ryan SL, Elliott DJ, Bignell GR, Futreal PA, Ellison DW, Bailey S, Clifford SC. Amplification and overexpression of Hsa-miR-3ob, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma. PLoS ONE 2009, 4(7), e6159.
• Wilson K, Case M, Minto L, Bailey S, Bown N, Jesson J, Lawson S, Vormoor J, Irving J. Flow minimal residue disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34⁺CD38^lowCD19⁺ in B-lineage childhoood acute lymphoblastic leukemia. Haematologica 2009, 95(4), 679-683.
• Hayden JT, Fruhwald MC, Hasselblatt M, Ellison DW, Bailey S, Clifford SC. Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children. Cell Cycle 2009. ,8 11 1806-1807.
• Trehan A, Cheetham T, Bailey S. Hypercalcemia in Acute Lymphoblastic Leukemia: An Overview. Pediatric Hematology & Oncology 2009, 31(6), 424-427.
• Bailey S, Skinner R. Paediatric Haematology and Oncology. Oxford, UK: Oxford University Press, 2009.
• Waugh S, Hayden J, Clark J, Saunders D, Taha Y, Taylor C, Valappil M, Bailey S. Prolonged detection of viral DNA in blood following life-threatening chickenpox in an immunocompromised child. Journal of Clinical Virology 2009, 44(2), 170-172.
• Anderton JA, Lindsey JC, Lusher ME, Gilbertson RJ, Bailey S, Ellison DW, Clifford SC. Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2. Neuro-oncology 2008, 10(6), 981-994.
• Case MC, Matheson E, Minto L, Hassan R, Harrison CJ, Bown NP, Bailey S, Vormoor J, Hall AG, Irving JAE. Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia. Cancer Research 2008, 68(16), 6803-6809.
• Hall, A.G., Sulong, S., Harrison, C., Minto, C.L.J., Bown, N.P., Case, M.C., Bailey, S., Irving, J.A.E. Assessment of aneuploidy in childhood acute lymphoblastic leukaemia using high density oligonucleotide arrays. Blood 2006, 108(11).
• Yeung, J., Kempski, H., Neat, M., Bailey, S., Smith, O., Brady, H. J. M. Characterization of the t(17;19) translocation by gene-specific fluorescent in situ hybridization-based cytogenetics and detection of the E2A-HLF fusion transcript and protein in patients' cells. Haematologica 2006, 91(3), 422-424.
• Sulong, S., Irving, J.A.E., Case, M.C., Minto, C.L.J., Bown, N., Bailey, S., Harrison, C., Hall, A.G. Comprehensive analysis of p16(INK4a) in childhood acute lymphoblastic leukemia reveals homozygous deletion, haploinsufficiency and acquired isodisomy at the 9p locus with intact p16(INK4a).. Blood 2006, 108(11).
• Lindsey, J. C., Lusher, M. E., Strathdee, G. R., Brown, R., Gilbertson, R. J., Bailey, S., Ellison, D. W., Clifford, S. C. Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours. International Journal of Cancer 2006, 118(2), 346-352.
• Lindsey JC, Lusher ME, Strathdee G, Brown R, Gilbertson RJ, Bailey S, Ellison DW, Clifford SC. Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours. International Journal of Cancer 2006, 118(2), 346-352.
• Dharmaraj P, Ball S, Johnstone H, Bailey S, Clifford SC, Hale J, Cheetham T. Hypercalcaemia in relapsed medulloblastoma 8 years post-diagnosis; evidence to support PTHrP production by medulloblastoma cells. Hormone Research 2006, 66(6), 268-272.
• Scott D, Straughton D, Cole M, Bailey S, Ellison DW, Clifford SC. Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma. Cell Cycle 2006, 5(20), 2381-2389.
• Irving, J.A.E., Minto, C.L.J., Matheson, E., Case, M.C., Bailey, S., Bown, N.P., Hassan, R., Harrison, C., Hall, A.G. Mutation in genes impacting on the RAS-RAF-MEK-ERK pathway are found at high incidence in childhood acute lymphoblastic leukemia at both diagnosis and at relapse.. Blood 2006, 108(11), 160B-161B.
• Irving, J.A.E., Minto, C.L.J., Bailey, S., Hall, A.G. Loss of heterozygosity and somatic mutations of the Glucocorticoid receptor gene are rarely found at relapse in pediatric acute lymphoblastic leukemia but may occur in a subpopulation early in the disease course. Cancer Research 2005, 65(21), 9712-9718.
• Lindsey JC, Lusher ME, Anderton J, Bailey S, Gilbertson R, Pearson ADJ, Ellison DW, Clifford SC. Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling. Carcinogenesis 2004, 25(5), 661-668.
• Bailey, S., Roberts, A., Brock, C., Price, L., Craft, A. W., Kilkarni, R., Lee, R. E. J., Skillen, A. W., Skinner, R. Nephrotoxicity in survivors of Wilms' tumours in the North of England. British Journal of Cancer 2002, 87(10), 1092-1098.
• Bailey, S., Hall, A. G., Pearson, A. D. J., Redfern, C. P. F. The role of AP-1 in glucocorticoid resistance in leukaemia. Leukemia 2001, 15(3), 391-397.
• Mann, J. R., Raafat, F., Robinson, K., Imeson, J., Gornall, P., Sokal, M., Gray, E., McKeever, P., Hale, J., Bailey, S., Oakhill, A. The United Kingdom Children's Cancer Study Group's second germ cell tumor study: Carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. Journal of Clinical Oncology 2000, 18(22), 3809-3818.
• Bailey, S., Hall, A.G., Pearson, A.D.J., Reid. M., Redfern, C.P.F. Glucocorticoid resistance and the AP-1 transcription factor in leukaemia. Advances in Experimental Medicine and Biology 1999, 457, 615-619.
• Bailey S, Lewis ME. Acute Lymphoblastic Leukaemia, The Wellington Experience 1980-1992. New Zealand Medical Journal 1996, 109, 9-11.
• Bailey, S., Skinner, R., Lucraft, H. H., Perry, R. H., Todd, N., Pearson, A. D. J. Pineal tumours in the north of England 1968-93. Archives of Disease in Childhood 1996, 75(3), 181-185.