Newcastle University

1.        The cellular response to DNA damage, specifically the ATR-Chk1 signal pathway, and the therapeutic potential of ATR inhibition.

2.        The role of epigenetics (DNA methylation and micro RNA) in cancer and early embryo development. 

• Chen T, Mally A, Ozden S, Chipman JK. Low Doses of the Carcinogen Furan Alter Cell Cycle and Apoptosis Gene Expression in Rat Liver Independent of DNA Methylation. Environmental Health Perspectives 2010, 118(11), 1597-1602.
• Edwards GO, Jondhale S, Chen T, Chipman JK. A quantitative inverse relationship between connexin32 expression and cell proliferation in a rat hepatoma cell line. Toxicology 2008, 253(1-3), 46-52.
• Chen T, Zhang YL. Interspecies nuclear transfer reveals that demethylation of specific repetitive sequences is determined by recipient ooplasm but not by donor intrinsic property in cloned embryos. Molecular Reproduction and Development 2006, 73(3), 313-317.
• Chen T, Zhang YL, et al. The DNA methylation events in normal and cloned rabbit embryos. FEBS Letters 2004, 578(1), 69-72.
• Chen T, Stephens PA, Middleton FK, Curtin NJ. Targeting the S and G2 checkpoint to treat cancer. Drug Discovery Today 2012, 17(5-6), 194-202.
• Peasland A, Wang LZ, Rowling E, Kyle S, Chen T, Hopkins A, Cliby WA, Sarkaria J, Beale G, Edmondson RJ, Curtin NJ. Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. British Journal of Cancer 2011, 105(3), 372-381.