Newcastle Preclinical In Vivo Imaging Facility

Newcastle Preclinical In Vivo Imaging

Our Mission

The Newcastle Preclinical In Vivo Imaging (PIVI) Facility integrates advanced technologies and expertise to study biological processes in living organisms non-invasively. PIVI offers streamlined and affordable solutions to researchers to assess disease progression and innovative therapies in small animal models that closely mimic patient conditions. With the 3Rs principles at its core, PIVI provides a window into deep structures and functions, aiding researchers in making informed decisions on disease progression and the efficacy and safety of new drugs in models across various areas, including but not limited to, chronic liver diseases, cardiovascular disease, cancer, immunology and inflammation, ageing, and mitochondrial disease.

Available Services

PIVI offers access and training to a range of clinically translatable in vivo imaging technologies, catering to a broad spectrum of research requirements. Through the Small Animal Models and Imaging (SAMI) special interest group, PIVI provides collaborative opportunities to access in vivo disease models that closely replicate patient conditions across various research areas.

Services

  • Experimental design
  • Image acquisition
  • Image analysis
  • Administration of drugs or contrast agents
    •                    Routes of administration (IV, IP, subcut, oral etc.)
  • Surgical procedures
    •                    Intrahepatic injection
    •                    Unilateral Ureter Obstruction (kidney fibrosis)

Technology

 

Workflow

PIVI offers guidance throughout the entire project lifecycle, encompassing planning, design, and execution to generation of qualitative datasets tailored to your specific project requirements.

Applications

PIVI imaging modalities are versatile tools for obtaining non-destructive structural and functional information across diverse fields, including biological processes and material sciences. They offer a non-invasive insight into anatomy, physiology, and molecular activities. Applications span biomarker discovery and validation, disease monitoring, drug design, and advancing understanding of conditions like cancer, immunology and inflammation, and cardiovascular disorders etc.

For more information on each system, please click on each specific imaging equipment.

 

Service Request

FAQ

Feedback

"We used the University CT scanning service to helps us improve our products. The scanning service was quick and of high quality. The team was easy to work with, knowledgeable and very helpful."

                                                                                                                                                                                                               Martin Newman, Senior Quality Engineer, Parker Hannifin Manufacturing Ltd

"The technical team really engaged with us to understand the type of images that we needed and was responsive. The resolution of the images was very good and the details of the sequence in the DICOM header were very descriptive enabling accurate post-processing of the data."

                                                                                                                                                                                                                Dr. Delphine Elbes, Engineering Manager, Orthoson