Postgraduate

modules

Modules

CSC8316 : Modelling Cellular Systems

Semesters
Semester 1 Credit Value: 10
ECTS Credits: 5.0

Aims

To understand how biological systems can be represented at different levels of abstraction.
To introduce a range of computational modelling approaches and to select an appropriate modelling strategy for a given biological domain and problem.
To understand how models may be used to represent cellular machinery at a systems level and how models can be used to generate biological hypotheses.

Outline Of Syllabus

Introduction to modelling biochemical systems.
Abstraction and levels of abstraction in modelling.
Structural models: ER modelling and network models.
Metabolic modelling using flux balance analysis.
Dynamic modelling using continuous differential equations.
Simulation.
Modelling discrete stochastic systems.
Parameter estimation and inference.
Biological hypothesis generation.
Model optimisation.

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture241:0024:00Lectures
Guided Independent StudyAssessment preparation and completion241:0024:00Lecture follow-up
Scheduled Learning And Teaching ActivitiesPractical121:0012:00Practicals
Guided Independent StudyProject work121:0012:00Coursework
Guided Independent StudyIndependent study281:0028:00Background reading
Total100:00
Teaching Rationale And Relationship

Lectures will be used to introduce the learning material and for demonstrating the key concepts by example. Students are expected to follow-up lectures within a few days by re-reading and annotating lecture notes to aid deep learning.

This is a very practical subject, and it is important that the learning materials are supported by hands-on opportunities provided by practical classes. Students are expected to spend time on coursework outside timetabled practical classes.

Students aiming for 1st class marks are expected to widen their knowledge beyond the content of lecture notes through background reading.

Assessment Methods

The format of resits will be determined by the Board of Examiners

Other Assessment
Description Semester When Set Percentage Comment
Practical/lab report1M504 practicals. Report - 1500 words max excluding figures and tables.
Practical/lab report1M504 practicals. Report - 1500 words max excluding figures and tables
Assessment Rationale And Relationship

The coursework will assess the students’ ability to understand and apply the concepts of a range of a biological modelling theories and techniques to a given biological system.

Reading Lists

Timetable