BGM3061 : Genetic variation in common disease
- Offered for Year: 2017/18
- Module Leader(s): Professor Julie Irving
- Lecturer: Professor John Loughlin, Dr Catherine Meplan, Professor Mark Walker, Professor Quentin Anstee, Professor Heather Cordell, Dr Daryl Shanley
- Owning School: Biomedical Sciences
- Teaching Location: Newcastle City Campus
|Semester 1 Credit Value:||10|
The module aims to use expertise in common human disease (eg., type II diabetes, osteoarthritis, non-alcoholic fatty liver disease and diseases associated with ageing) to;
• explore the principle that nearly all human disease has a genetic component and that several common diseases do not fit into simple Mendelian patterns of inheritance but fall into the category of disease genetics termed “complex disease”.
• consider how the genetic (heritable) component of a complex disease (CD) can be assessed and how genes responsible for CD can be identified and this knowledge used in diagnosis and patient management.
• consider the role of inherited variation in genes and drug responses (pharmacogenetics).
• consider how knowledge of disease genetics informs the debate about disease pathogenesis and the social and ethical issues that can arise from the genome project and from the use and misuse of genetics and genetic information.
Outline Of Syllabus
The module covers the following broad issues:
• Definition of complex diseases
• How to identify and assess the heritable component of a complex disease
• Selecting and applying different research strategies
• Linkage versus association analysis
• Data Interpretation
• Knowledge of key examples of complex diseases.
• Social and Ethical issues arising from the study of complex diseases
|Scheduled Learning And Teaching Activities||Lecture||11||1:00||11:00||Primary method for knowledge transfer|
|Scheduled Learning And Teaching Activities||Small group teaching||1||1:00||1:00||Seminar|
|Guided Independent Study||Independent study||88||1:00||88:00||N/A|
Teaching Rationale And Relationship
This is an undergraduate module based on an area of research excellence within the University. The module is mostly based on lectures with open discussion of key concepts. The learning outcomes are predominantly knowledge based with key skills in critical evaluation and written communication of that knowledge being assessed. In addition there is assessment of data interpretation which will test the student’s understanding of key principles on which the taught material is based and basic numeracy. The seminar provides the students with an opportunity to have a broad based discussion of some of the major issues in medical science in the presence of their peers.
The format of resits will be determined by the Board of Examiners
|Written Examination||60||2||A||80||One essay question to be answered from a choice of two.|
|Essay||1||M||20||Timed Essay 1 hour in length|
Assessment Rationale And Relationship
The examination tests evidence of knowledge and understanding of the topics. The timed essay tests the discipline knowledge and writing skills under time constrained conditions and as preparation for the final examination.