BGM2056 : DNA Replication, recombination and Repair

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  • Owning School:
Semesters
Semester 2 Credit Value: 10
ECTS Credits: 5.0

Aims

1. To provide a sound understanding of the molecular mechanisms underlying the replication, repair and recombination of DNA and to demonstrate the unique importance of the accuracy of these processes.

2. To provide a framework for understanding the different types of DNA damage, the mechanisms by which they are repaired and the diseases that result from defects in these repair processes.

Original Summary:
This module provides an understanding of key DNA-dependent processes, such as the accurate replication of the genome and recombination, the mechanism which underpins genetic variation. Importantly, DNA is subject to constant damage and failure to accurately repair this damage results in mutations which lead to genetic instability and ultimately cancer. Therefore, a major component of the module focuses upon the mechanisms by which DNA damage is repaired and also considers the many devastating human diseases (e.g. developmental disorders, cancer predisposition and
premature ageing) that arise from defects in DNA repair processes. In course assessment (worth 20% of the module mark) is based upon a practical and a seminar session. The remaining assessment is by a written examination (mixture of EMI and essays).

Outline Of Syllabus

This module provides an understanding of the following key DNA-dependent processes:

accurate replication of the genome and recombination;
mechanisms of genetic variation;
repair of DNA damage;
results of failure to correct DNA damage (e.g. mutation, genetic instability, cancer).
development of genetics diseases (e.g. developmental disorders, cancer predisposition and premature ageing)

Teaching Methods

Teaching Activities
Category Activity Number Length Student Hours Comment
Scheduled Learning And Teaching ActivitiesLecture121:0012:00N/A
Scheduled Learning And Teaching ActivitiesPractical16:006:00N/A
Scheduled Learning And Teaching ActivitiesDrop-in/surgery11:001:00Seminar on practical results
Guided Independent StudyIndependent study181:0081:00N/A
Total100:00
Teaching Rationale And Relationship

The lectures will be used to introduce the intended knowledge outcomes for the module. These will be reinforced by the material covered in the data analysis and practical sessions. The seminar will reinforce the lecture material and act as a feedback session for the practical and data-handing exercise. One seminar will be sufficient to cover this material (this is based on previous experience of running this section of the module as a strand in a number of other modules BGM2036, BGM2037 and BGM2038).

Assessment Methods

The format of resits will be determined by the Board of Examiners

Exams
Description Length Semester When Set Percentage Comment
Written Examination602A80EMI (30%): 30 minutes Essay x 1 (70%): 45 minutes.
Other Assessment
Description Semester When Set Percentage Comment
Practical/lab report2M20Students will gain experience in the accurate recording and also with determination of UV survival curves
Assessment Rationale And Relationship

The assessments will test understanding of the material delivered, as well as providing training in key laboratory and
numeracy skills.

Reading Lists

Timetable

Disclaimer: The University will use all reasonable endeavours to deliver modules in accordance with the descriptions set out in this catalogue. Every effort has been made to ensure the accuracy of the information, however, the University reserves the right to introduce changes to the information given including the addition, withdrawal or restructuring of modules if it considers such action to be necessary.