Institute for Ageing

The Science of Ageing

Understanding the Science of Ageing

Our researchers work at the frontier of science to investigate complex molecular mechanisms in our cells to discover where faults and malfunctioning lead to ageing.


We led the world by identifying and explaining dementia with Lewy bodies. Our research continues to discover the causes of this and other forms of dementia such as Alzheimer's Disease - and importantly to find treatments.


Our researchers have discovered a potentially important breakthrough. Fibrosis (or scarring) may be influenced not just by your lifestyle - susceptibility may be transmitted from one generation to another.


One of the areas of study in Newcastle is a way of modifying stem cells to produce cartilage. When connective tissue breakdown occurs it may be possible in future to replenish it to overcome the onset of arthritis.


Our research suggests that damage to mitochondrial DNA could contribute to the ageing process and regular exercise could help improve mitochondrial function. Pioneering research has also revealed how damage to telomeres (molecules found on the ends of chromosomes in the nucleus of body cells) possibly causes age-related diseases.

Newcastle - a centre of excellence in ageing

Researchers are eager to work alongside established experts in Newcastle with access to the best facilities. Dr João Passos, Research Fellow from Portugal is carrying out independent research in cellular ageing, bringing colleagues from Portugal to bolster his team.

Interviews with our experts