Isolation of polyacetylenes from carrots and testing of their effect on an aspect of the ageing process
Project title: Isolation of polyacetylenes from carrots and testing of their effect on an aspect of the ageing process
Lead: Dr Michael Carroll, Senior Lecturer, School of Chemistry, SAgE
Carrot intake is significantly associated with several indicators of ageing-related health benefits, including telomere length and reduced cancer mortality. This project aims to to isolate pure material of three key polyacetylenes in sufficient amounts for detailed biological evaluation, and then investigate effects oncellular ageing, measuringtelomere-associated DNA damage foci, the most sensitive cellular senescence marker presently known.
Find out more about Dr Carroll's project.
Frailty, Multi-morbidity and the use of Health and Social Care Resources
Project title: Exploring the relationship between frailty, multi-morbidity and the use of health and social care resources in the oldest old
Lead: Dr Karen Davies, Senior Research Associate, Institute of Health and Society, Faculty of Medical sciences
Examining data from the Newcastle 85+ Study provides a unique opportunity to build a detailed picture about the type of health and social services very old people use, how often, and how this changes as they age further.
Find out more about Dr Davies' project.
Methodological investigations in capturing the impact of museum activities on older men, living with mental illness
Project title: Methodological investigations in capturing the impact of museum activities on older men, living with mental illness
Lead: Dr Areti Galani, International Centre for Cultural & Heritage Studies, School of Arts and Cultures, Faculty of Humanities and Social Sciences
Working with staff at Beamish Open Air Museum and the Mental Health Services for Older People (TEWV) in Derwent Clinic (Co. Durham), this project aims to identify better methods of capturing the impact(s) of skills-oriented structured engagements with the museum environment and its collections for a group of older men with a range of mental health conditions.
Find out more about Dr Galani's project.
Instrumented Fall Detection
Project title: A feasibility study of instrumented fall detection within the ICICLE-Gait cohort
Lead: Dr Alan Godfrey, Senior Research Associate, Institute of Neuroscience, Faculty of Medical Sciences
This feasibility study aimed to analyse accelerometer-based body worn monitor (BWM) data collected in a longitudinal study (ICICLE-Gait) to examine real-world falls in people with Parkinson's disease (PD). Find out more about Dr Godfrey's project.
Understanding chemotherapy treatment decisions in older lung cancer patients
Project title: Understanding chemotherapy treatment decisions in older lung cancer patients: the potential value of individual toxicity risk scores
Lead: Dr Alastair Greystoke, Clinical Fellow and Honorary Consultant in Medical Oncology, Northern Institute for Cancer Research, Faculty of Medical Sciences
Each year 26,000 people aged 70 or older are diagnosed with lung cancer in the UK. This study will use in-depth interviews to determine, among patients with lung cancer, their views and attitudes towards chemotherapy; what side-effects are acceptable; and whether knowledge of their individual risk for severe toxicity would affect their decisions around accepting chemotherapy.
Find out more about Dr Greystoke's project.
Gut Microbiota and Inflammation
Project title: Healthy Ageing: Gut microbiota and inflammation
Lead: Dr David Houghton, Research Associate, Institute of Cellular Medicine, Faculty of Medical Sciences
The aim of the proposed research is to understand how lifestyle interactions affect gut microbiota and build research capacity at Newcastle University.
Find out more about Dr Houghton's project.
Consulting with people with aphasia about research: Development of a sustainable model to facilitate future research
Project title: Consulting with people with aphasia about research: Development of a sustainable model to facilitate future research and research bids
Lead: Dr Julie Morris, Head of Speech and Language Sciences, Faculty of Humanities and Social Sciences
Within aphasia research at Newcastle we have a strong record of working with people with aphasia when we generate research ideas, design, conduct and manage research studies. This proposal is to fund a speech and language therapist to work with Aphasia Researcher User Group members to develop formal processes for the group.
Find out more about Dr Morris' project.
Optimising redox signal transduction to promote healthy ageing
Project title: Optimising redox signal transduction to promote healthy ageing
Lead: Dr Elizabeth Veal, Reader in Molecular Biology, Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences
There is growing evidence that chemicals which are toxic at higher levels, such as naturally occurring metabolites of oxygen and chemicals in the diet, can function as signals, triggering programmes that protect against age-associated illnesses and extend lifespan. The goal of this proposal will be to investigate whether targeting specific proteins, genetically or with drugs, increases the lifespan of nematode worms and improves the ability of muscle cells to adapt and survive under stress conditions.
Find out more about Dr Veal's project.