Institute for Ageing

Event Items

Haematopoietic stem cell niches during ageing and age-related myeloid malignancies

The Newcastle Institute for Cancer Research welcome a guest lecture by Dr Simón Méndez-Ferrer from University of Cambridge.

Date/Time: Monday 25th June, 2018 - 13:00

Venue: Paul O'Gorman Building, NICR

The Newcastle Institute for Cancer Research welcome a guest lecture by Dr Simón Méndez-Ferrer from University of Cambridge.

Event details:

Time and location: Monday 25th June, 1pm, Paul O'Gorman Building

Speaker: Dr Simón Méndez-Ferrer, University of Cambridge 

Title: Haematopoietic stem cell niches during ageing and age-related myeloid malignancies

Abstract: Haematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during aging but are functionally impaired. However, the role of HSC-intrinsic and -extrinsic aging mechanisms remains debated.

Premature aging in Hutchinson-Gilford progeria syndrome (HGPS) recapitulates physiological aging features, but whether these arise from altered stem and/or niche cells is unknown. I will present evidence showing that the murine BM microenvironment promotes stem/progenitor cell myeloid bias in normal aging and HGPS.

Moreover, niche aging might represent a therapeutic target in age-related pathological disorders, such as myeloproliferative neoplasms (MPNs). MPNs can be considered preleukemic disorders because MPN patients have higher risk of developing acute myeloid leukaemia (AML).

However, for reasons not fully clear, the transformation rates are very different across distinct MPN subsets (myelofibrosis > polycythemia vera (PV) > essential thrombocythemia (ET)), despite the fact that mutated HSCs may carry the same oncogenic driver mutation (e.g. JAK2-V617F).

I will present evidence that HSCs carrying the same mutation (JAK2-V617F) exhibit different microenvironmental requirements in murine models of ET and PV, and thereby cause differential niche remodelling in two diseases associated with different progression.