Institute for Ageing

Event Items

Redox Signalling in physiology, ageing and disease

A Joint Biochemical Society and British Society for Research on Ageing (BSRA) Scientific Meeting

Date/Time: 1 - 3 July 2019

Venue: Copthorne Hotel, Newcastle upon Tyne

Oxidative damage caused by reactive oxygen species (ROS) is associated with the development and progression of a number of plant and animal diseases, including age-associated human diseases, such as cancer, cardiovascular disease and neurodegeneration. However, the widely-held view that ROS cause ageing has been challenged in recent years, particularly following studies by researchers in the ageing field indicating that ROS are important for the life-extending effects of certain dietary regimes and genetic changes.

In parallel, the last 15 years have seen the emergence of a new field of redox signal transduction, following the establishment that ROS play important roles in promoting a diverse range of physiological responses important for plant and animal health. Since understanding these mechanisms is vital for new therapeutic strategies to prevent and treat diseases prevalent in ageing populations, as well as to deal with the challenges climate change places on plants, redox regulation is a topical and important area of study from scientific, medical and economic perspectives. 

The goal of this meeting is to bring biochemists, cell and systems biologists investigating redox-signalling mechanisms in a variety of systems, together with those working on the biological mechanisms underlying ageing and age-associated diseases. As such this meeting with provide an interdisciplinary forum for discussion of new approaches to the study of redox regulation, the mechanisms involved, and the role of redox dysregulation in health, ageing and disease.

Topics will include:
• Biological sources and metabolism of reactive oxygen species
• Tools for measuring ROS, redox changes and elucidating redox-signalling mechanisms
• Redox-regulated physiological processes and stress responses
• Biochemistry of redox-signalling; thiol oxidation, redox-relays, redoxin systems and glutathione
• The roles of ROS in ageing and disease

Earlybird registration deadline: Wednesday 1 May 2019