Institute for Ageing

Staff Profile

Dr Elizabeth Veal

Reader in Molecular Biology

Background

Qualifications

BSc (Hons) Liverpool 1992
PhD Liverpool 1996

Previous Positions

1996-1998 Grace Gill's lab at Harvard Medical School where I worked on regulation of mammalian transcription and CREG (cellular repressor of EIA-like genes).
1998-2003 Brian Morgan's lab at University of Newcastle investigating the regulation of eukaryotic oxidative stress responses

2004-2008 MRC Career Development Fellow, Newcastle University

2006-2011 RCUK Academic Fellow, Newcastle University

Memberships

Biochemical Society, Genetics Society, Genetics Society of America, British Society for Research on Ageing, Society for Redox Biology and Medicine 

Honours and Awards

MRC Career Development Award (2003-2008)


https://www.researchgate.net/profile/Elizabeth_Veal

 

Research

Research Interests

Exposure to sunlight, immune cell attack and aerobic metabolism generate highly toxic chemicals known as 'reactive oxygen species (ROS)'. These ROS, such as peroxide, cause cell damage (oxidative stress) that has been implicated in the initiation and development of many diseases, including cancer, heart disease and diabetes. Increased oxidative damage is also associated with ageing. We are interested in understanding the molecular mechanisms by which eukaryotic cells sense and respond to ROS, for example, to signal an increase in the production of protective proteins. We use the fission yeast Schizosaccharomyces pombe and the nematode worm Caenorhabditis elegans as genetically amenable model eukaryotes in which to study these ROS-sensing and signalling mechanisms. In multicellular organisms, in addition to causing oxidative stress, ROS are also generated and employed as signalling molecules to regulate various biological processes as well as part of the innate immune response to infection. The simplicity, ease of genetic manipulation and analysis, as well as the wide-range of post-genomic resources available, render C. elegans an ideal multicellular organism in which to identify cell-type specific roles for ROS-signalling mechanisms in development, the innate immune defence against pathogens and ageing. We also use both experimental and computational approaches to examine how ROS-sensing mechanisms identified in yeast and worms are conserved in human cells.

Lab Members

Joanne Stamford, Michelle Wray, Marti Cadena-Sandoval, Martin Galler, Min Cao

Former lab members and what-they-did-next:

2004-2013 Alison Day PhD moved to postdoc position after postdoc in Veal lab; 2005-2008 Sarah Taylor PhD became NHS cytogeneticist after PhD in Veal lab;  2005-2011 Monika Olahova PhD awarded faculty medal for PhD in Veal lab, postdoc in Veal lab, then postdoc fellow in USA; 2007-2012 Helen Crook PhD trained as high school science teacher after MRes/PhD and short postdoc in Veal lab; 2009-2013 Emma Button PhD moved to Industrial R&D position after MRes/PhD in Veal lab; 2007-2010, Jonathan Rand PhD moved to industrial R &D position after postdoc in Veal lab; 2009-2013 Jonathon Brown PhD moved to postdoc position after postdoc in Veal lab; 2011-2015 Lewis Tomalin postdoc at Rockefeller University, USA after PhD in Veal lab; 2012-2016 Heather Latimer became a medical writer after MRes/PhD in Veal lab; 2012-2016 Johnathan Winter position in biomedical research company after PhD in Veal lab; 2015-2018 Zoe Underwood research position at Public Health England after PhD in Veal lab.

Funding

Our work has been funded by the MRC, BBSRC, Research Councils UK and Cancer Research UK. Current work is funded by the BBSRC. We are always interested in considering applications from prospective international students or postdocs.

Latest News

2018:

Registration for Biochemistry Society Redox meeting in Newcastle July 1-3rd 2019 now open: https://www.biochemistry.org/Events/tabid/379/MeetingNo/SA221/view/Conference/Default.aspx   

MRC iCASE studentship available for start in September 2019! Informal enquiries welcomed!

Congratulations to Zoe on a successful PhD thesis defence and her new job at Public Health England

Congratulations to Johny on publication of his joint first author paper in Aging Cell 

2016:

Congratulations to Monika on receiving the Aging Cell Runner-Up Best Paper Prize for 2015!

http://www.anatsoc.org.uk/funding-and-awards/grants-and-prizes/aging-cell-best-paper-prize/latest-recipient-aging-cell-best-paper-prize

for her paper: Oláhová M, Veal EA. A peroxiredoxin, PRDX-2, is required for insulin secretion and Insulin/IIS-dependent regulation of stress resistance and longevity. Aging Cell 2015, 14(4), 558-568. 

 

Publications